Target Name: RNF144B
NCBI ID: G255488
Review Report on RNF144B Target / Biomarker Content of Review Report on RNF144B Target / Biomarker
RNF144B
Other Name(s): P53-inducible RING finger protein | R144B_HUMAN | p53RFP | p53-inducible RING finger protein | IBRDC2 | IBR domain-containing protein 2 | bA528A10.3 | PIR2 | ring finger protein 144B | IBR domain containing 2 | P53RFP | E3 ubiquitin-protein ligase RNF144B | RING finger protein 144B | BA528A10.3 | Ring finger protein 144B

Understanding The Potential Therapeutic Applications of RNF144B

The rapid development of new treatments for various diseases has led to an increasing interest in the research of gene-related biomarkers and drug targets. One such biomarker, named RNF144B (P53-inducible RING finger protein), has gained significant attention due to its potential as a drug target or a diagnostic tool. In this article, we will explore the biology, function, and potential therapeutic applications of RNF144B.

Biochemistry and Structure

RNF144B is a 21-kDa protein that is expressed in various tissues, including liver, spleen, lung, and brain. It is composed of a unique N-terminal domain, a central B-domain, and a C-terminal T-domain. The N-terminal domain contains a nucleotide-binding oligomerization domain (NBO), which is responsible for the protein's nuclear localization and functions as a nuclear localhost for various transcription factors. The B-domain is known for its unique fusiform structure, which is composed of a specific arrangement of secondary structure elements, including a 尾-sheet and a 尾-hairline. The C-terminal T-domain is rich in conserved acidic and basic residues, which contribute to its overall stability and function.

Function

RNF144B plays a critical role in the regulation of gene expression and is involved in various cellular processes, including DNA replication, transcription, and apoptosis. Its functions are highly conserved between various species, and the protein has been involved in numerous cellular processes, including cell growth, cell cycle progression, and cell survival.

One of the most significant functions of RNF144B is its role in the regulation of apoptosis. Apoptosis is a natural phenomenon that is responsible for the elimination of damaged or dysfunctional cells. The loss of RNF144B has been observed to promote the growth and survival of cancer cells , suggesting that it may have a negative impact on cancer cell survival.

In addition to its role in apoptosis, RNF144B is also involved in the regulation of DNA replication and transcription. Its NBO domain has been shown to interact with various DNA-binding proteins, including the transcription factor TF-BP1, leading to the recruitment of TF -BP1 to the N-end of the DNA. This interaction between RNF144B and TF-BP1 suggests a potential role for RNF144B in regulating gene expression.

Potential Therapeutic Applications

The therapeutic potential applications of RNF144B are vast, and numerous studies have investigated its potential as a drug target or biomarker. One of the most promising avenues for research is the use of RNA interference (RNAi) technology to knockdown the expression of RNF144B and evaluate its effects on various cellular processes.

RNAi-mediated knockdown of RNF144B has been shown to have a variety of potential therapeutic applications. For example, it has been used to reduce the size of tumors and improve the survival of cancer patients. In addition, RNAi-mediated knockdown of RNF144B has been shown to protect against neurodegenerative diseases, such as Alzheimer's and Parkinson's diseases.

Another promising application of RNF144B is its potential as a biomarker for various diseases, including cancer. The loss of RNF144B has been observed in various types of cancer, and RNAi-mediated knockdown of RNF144B has been shown to enhance the sensitivity of cancer cells to chemotherapy.

Conclusion

In conclusion, RNF144B is a unique and highly conserved protein that plays a critical role in various cellular processes. Its functions as a nuclear localhost for transcription factors and its involvement in the regulation of apoptosis, DNA replication, and transcription make it an attractive target for therapeutic intervention. The potential therapeutic applications of RNF144B are vast, and further research is needed to fully understand its functions and potential as a drug

Protein Name: Ring Finger Protein 144B

Functions: E3 ubiquitin-protein ligase which accepts ubiquitin from E2 ubiquitin-conjugating enzymes UBE2L3 and UBE2L6 in the form of a thioester and then directly transfers the ubiquitin to targeted substrates such as LCMT2, thereby promoting their degradation. Induces apoptosis via a p53/TP53-dependent but caspase-independent mechanism. However, its overexpression also produces a decrease of the ubiquitin-dependent stability of BAX, a pro-apoptotic protein, ultimately leading to protection of cell death; But, it is not an anti-apoptotic protein per se

The "RNF144B Target / Biomarker Review Report" is a customizable review of hundreds up to thousends of related scientific research literature by AI technology, covering specific information about RNF144B comprehensively, including but not limited to:
•   general information;
•   protein structure and compound binding;
•   protein biological mechanisms;
•   its importance;
•   the target screening and validation;
•   expression level;
•   disease relevance;
•   drug resistance;
•   related combination drugs;
•   pharmacochemistry experiments;
•   related patent analysis;
•   advantages and risks of development, etc.
The report is helpful for project application, drug molecule design, research progress updates, publication of research papers, patent applications, etc. If you are interested to get a full version of this report, please feel free to contact us at BD@silexon.ai

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