GABRB2: GPCR Role in Pain, Anxiety and Neurotransmission (G2561)

Target Name: GABRB2

NCBI ID: G2561

GABRB2

GABRB2: GPCR Role in Pain, Anxiety and Neurotransmission

GABRB2 (Gamma-aminobutyric acid receptor subunit beta-2) is a G protein-coupled receptor (GPCR) that is expressed in various tissues and plays a crucial role in cellular signaling. It is a key regulator of neural transmission, and its function is closely associated with the modulation of pain, anxiety, and other physiological processes. GABRB2 has also been identified as a potential drug target and a biomarker for various psychiatric and neurological disorders.

The GABRB2 receptor is a GPCR that is characterized by the presence of a transmembrane domain, a catalytic domain, and an extracellular loop. The transmembrane domain is responsible for the receptor's membrane expression, while the catalytic domain is responsible for the receptor's catalytic activity. The extracellular loop is involved in the formation of the GABRB2 receptor complex with other proteins, such as GABA (Gamma-aminobutyric acid), which is the natural ligand for the receptor.

GABRB2 is involved in the regulation of a wide range of physiological processes, including pain perception, anxiety, and neurotransmitter release. It is a potent modulator of pain perception, and its activation can significantly reduce the intensity of pain. GABRB2 has also been shown to play a role in the regulation of anxiety and other mood-related behaviors.

In addition to its role in pain and anxiety, GABRB2 is also involved in the regulation of neurotransmitter release and neurotransmission. It is a critical regulator of GABAergic neurotransmission, and its activation can significantly modulate the levels of GABA in the brain. GABRB2 has also been shown to play a role in the regulation of dopamine release, and its activation can significantly reduce the levels of dopamine in the brain.

GABRB2 has also been identified as a potential drug target and a biomarker for various psychiatric and neurological disorders. For example, GABRB2 has been shown to be involved in the pathophysiology of major depressive disorder (MDD), and its activation has been associated with increased levels of depressive-like behavior in mice. GABRB2 has also been shown to be involved in the pathophysiology of anxiety disorders, and its activation has been associated with increased levels of anxiety-like behavior in mice.

In addition to its potential therapeutic applications, GABRB2 has also been identified as a potential biomarker for various psychiatric and neurological disorders. For example, GABRB2 has been shown to be involved in the regulation of depressive-like behavior in mice, and its levels have been shown to be reduced in individuals with major depressive disorder (MDD). GABRB2 has also been shown to be involved in the regulation of anxiety-like behavior in mice, and its levels have been shown to be reduced in individuals with anxiety disorders.

GABRB2 has also been shown to play a role in the regulation of pain perception and neurotransmission. Its activation has been shown to significantly reduce the intensity of pain in animals, and its levels have been shown to be reduced in individuals with pain-related disorders. GABRB2 has also been shown to play a role in the regulation of neurotransmission, and its activation has been shown to significantly modulate the levels of neurotransmitters in the brain.

In conclusion, GABRB2 is a GPCR that is involved in the regulation of various physiological processes, including pain perception, anxiety, and neurotransmission. Its function is closely associated with the modulation of pain, anxiety, and other physiological processes. GABR

Protein Name: Gamma-aminobutyric Acid Type A Receptor Subunit Beta2

Functions: Ligand-gated chloride channel which is a component of the heteropentameric receptor for GABA, the major inhibitory neurotransmitter in the brain (PubMed:8264558, PubMed:19763268, PubMed:27789573, PubMed:29950725). Plays an important role in the formation of functional inhibitory GABAergic synapses in addition to mediating synaptic inhibition as a GABA-gated ion channel (PubMed:23909897, PubMed:25489750). The gamma2 subunit is necessary but not sufficient for a rapid formation of active synaptic contacts and the synaptogenic effect of this subunit is influenced by the type of alpha and beta subunits present in the receptor pentamer (By similarity). The alpha1/beta2/gamma2 receptor and the alpha2/beta2/gamma2 receptor exhibit synaptogenic activity (PubMed:23909897, PubMed:25489750). Functions also as histamine receptor and mediates cellular responses to histamine (By similarity)

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