SUN3: A Drug Target for Cell Signaling AndApoptosis (G256979)

Target Name: SUN3

NCBI ID: G256979

SUN3

SUN3: A Drug Target for Cell Signaling AndApoptosis

SUN3 (SUN domain-containing protein 3 (isoform 1)) is a protein that is expressed in various cell types of the human body, including the liver, lung, and kidney. It is a 22 kDa protein that contains a N-terminal Sun domain, a unique farnesylated cysteine residue, and a C-terminal protein domain. The Sun domain is a conserved region that is found in various proteins that are involved in various cellular processes, including cell signaling, DNA replication, and protein-protein interactions. The farnesylated cysteine residue is a modified cysteine residue that is involved in protein stability and functions as a general base. The C-terminal protein domain is responsible for the protein's unique structure and function.

SUN3 is a key regulator of various cellular processes that are essential for the survival of the cell. It is involved in the regulation of cell signaling pathways, including the production of reactive oxygen species (ROS), cell apoptosis, and inflammation. It is also involved in the regulation of cell cycle progression, DNA replication, and protein-protein interactions.

Drug Targeting

SUN3 is a drug target of great interest due to its involvement in various cellular processes that are crucial for the survival of the cell. Activation of SUN3 has been shown to have a variety of therapeutic effects, including the inhibition of cell apoptosis, the production of ROS, and the regulation of cell cycle progression.

One of the potential therapeutic strategies for targeting SUN3 is to inhibit its activity as a negative regulator of cell apoptosis. Sun3 has been shown to play a negative role in the regulation of cell apoptosis, which is the process by which cells die as a result of various factors, including DNA damage, UV radiation, and malware infections. In order to inhibit the negative regulation of cell apoptosis by SUN3, researchers have developed various small molecules, including inhibitors of DNA-protein binding, which can inhibit the activity of the Sun3 protein.

Another potential therapeutic strategy for targeting SUN3 is to activate its activity as a protein kinase. Sun3 has been shown to play a positive role in the regulation of protein-protein interactions and cell signaling pathways. Activation of Sun3 has been shown to increase the activity of several protein kinases, including PKA, PKC, and FAK. By activating the activity of these protein kinases, researchers can target specific cellular processes that are regulated by SUN3 and enhance the therapeutic effects of various drugs.

Biomarker

SUN3 is also a potential biomarker for various diseases, including cancer, neurodegenerative diseases, and autoimmune diseases. Its involvement in various cellular processes that are crucial for the survival of the cell makes it an attractive marker for these diseases.

In cancer, Sun3 has been shown to play a negative role in the regulation of cell apoptosis, which is the process by which cells die as a result of various factors, including DNA damage, UV radiation, and malware infections. By inhibiting the negative regulation of cell apoptosis by Sun3, researchers have found that the therapeutic effects of anti-cancer drugs may be enhanced.

In neurodegenerative diseases, Sun3 has been shown to play a positive role in the regulation of protein-protein interactions and cell signaling pathways. Its activation may contribute to the development and progression of neurodegenerative diseases.

In autoimmune diseases, Sun3 has been shown to play a negative role in the regulation of cell apoptosis. Its inhibition may contribute to the development and progression of autoimmune diseases.

Conclusion

SUN3 is a protein that is involved in various cellular processes that are essential for the survival of the cell. Its involvement in cell signaling pathways, DNA replication, and protein-protein interactions makes it an attractive target for

Protein Name: Sad1 And UNC84 Domain Containing 3

Functions: As a probable component of the LINC (LInker of Nucleoskeleton and Cytoskeleton) complex, involved in the connection between the nuclear lamina and the cytoskeleton. The nucleocytoplasmic interactions established by the LINC complex play an important role in the transmission of mechanical forces across the nuclear envelope and in nuclear movement and positioning. May be involved in nuclear remodeling during sperm head formation in spermatogenesis. A probable SUN3:SYNE1 LINC complex may tether spermatid nuclei to posterior cytoskeletal structures such as the manchette

The "SUN3 Target / Biomarker Review Report" is a customizable review of hundreds up to thousends of related scientific research literature by AI technology, covering specific information about SUN3 comprehensively, including but not limited to:
•   general information;
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•   protein biological mechanisms;
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•   the target screening and validation;
•   expression level;
•   disease relevance;
•   drug resistance;
•   related combination drugs;
•   pharmacochemistry experiments;
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•   advantages and risks of development, etc.
The report is helpful for project application, drug molecule design, research progress updates, publication of research papers, patent applications, etc. If you are interested to get a full version of this report, please feel free to contact us at BD@silexon.ai

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