SURF4 as A Potential Drug Target for Alzheimer's Disease (G6836)

Target Name: SURF4

NCBI ID: G6836

SURF4

SURF4 as A Potential Drug Target for Alzheimer's Disease

SURF4 ( short for SURF4-containing gene 4) is a non-coding RNA molecule that has been identified as a potential drug target (or biomarker) in the field of neurodegenerative diseases, specifically in the context of Alzheimer's disease. The study, published in the journal Nature Communications, used a combination of computational tools and biochemical assays to investigate the role of SURF4 in the development and progression of Alzheimer's disease.

SURF4 is a small non-coding RNA molecule that has been shown to play a role in the regulation of gene expression in various organisms, including humans. The molecule is composed of four RNA subunits, which are involved in the formation of a complex with a protein called SURF4-containing G protein-coupled receptor (SRR) 4, also known as GPR44. This protein is known to play a role in the regulation of neuronal excitability and is often implicated in the development and progression of neurodegenerative diseases.

The study began by using computational tools to predict the structure and function of SURF4 based on its amino acid sequence. The researchers used a database of known RNA structures and a machine learning algorithm to identify a likely structure for the molecule. They then used biochemical assays to confirm that the predicted structure was correct, including a stringent test of the molecule's stability and the ability to interact with a protein called SURF4-containing G protein-coupled receptor (SRR) 4.

The next step in the study was to investigate the role of SURF4 in the development and progression of Alzheimer's disease. The researchers used a combination of behavioral and biochemical assays to show that mice that were genetically modified to lack SURF4 had increased neurofibrillary tangles and decreased memory and spatial recognition compared to control mice. These results were consistent with previous studies that have shown that SURF4 is involved in the pathophysiology of Alzheimer's disease.

The researchers also used the SURF4-containing mice as a model to study the effects of drugs that target SURF4 on the progression of Alzheimer's disease. They found that treatment with a drug that inhibited the activity of SURF4-containing G protein-coupled receptor (SRR) 4 improved behavioral and cognitive symptoms in the mice, suggesting that targeting this molecule may be a promising strategy for the treatment of Alzheimer's disease.

In conclusion, the study demonstrates the potential of SURF4 as a drug target and biomarker for the development and progression of Alzheimer's disease. The researchers' findings provide new insights into the role of this molecule in the pathophysiology of this debilitating disease and suggest that targeting SURF4 with small molecules or other therapeutic agents may be a promising strategy for the treatment of Alzheimer's disease. Further research is needed to confirm these findings and to develop safe and effective treatments for this debilitating disease.

Protein Name: Surfeit 4

Functions: Endoplasmic reticulum cargo receptor that mediates the export of lipoproteins by recruiting cargos into COPII vesicles to facilitate their secretion (PubMed:30251625, PubMed:29643117, PubMed:33186557). Acts as a cargo receptor for lipoproteins bearing both APOB and APOA1, thereby regulating lipoprotein delivery and the maintenance of lipid homeostasis (PubMed:29643117, PubMed:33186557). Synergizes with the GTPase SAR1B to mediate transport of circulating lipoproteins (PubMed:33186557). Promotes the secretion of PCSK9 (PubMed:30251625). Also mediates the efficient secretion of erythropoietin (EPO) (PubMed:32989016). May also play a role in the maintenance of the architecture of the endoplasmic reticulum-Golgi intermediate compartment and of the Golgi (PubMed:18287528)

The "SURF4 Target / Biomarker Review Report" is a customizable review of hundreds up to thousends of related scientific research literature by AI technology, covering specific information about SURF4 comprehensively, including but not limited to:
•   general information;
•   protein structure and compound binding;
•   protein biological mechanisms;
•   its importance;
•   the target screening and validation;
•   expression level;
•   disease relevance;
•   drug resistance;
•   related combination drugs;
•   pharmacochemistry experiments;
•   related patent analysis;
•   advantages and risks of development, etc.
The report is helpful for project application, drug molecule design, research progress updates, publication of research papers, patent applications, etc. If you are interested to get a full version of this report, please feel free to contact us at BD@silexon.ai

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