GASK1B: A GPCR-Family Protein with Unique Structure and Biochemical Properties

Target Name: GASK1B

NCBI ID: G51313

GASK1B

GASK1B: A GPCR-Family Protein with Unique Structure and Biochemical Properties

GASK1B (Gastrin-Releasing and Stimulated Activated Kappa-B (GRKB)) is a protein that is expressed in various tissues throughout the body, including the brain, pancreas, and gastrointestinal tract. It is a member of the G protein-coupled receptor ( GPCR) family, which is a large family of transmembrane proteins that play a crucial role in cellular signaling.

GASK1B is characterized by its extracellular domain, which consists of a catalytic alpha-helices and a long conserved cytoplasmic tail. It has been shown to play a role in various physiological processes, including cell signaling, hormone regulation, and neurotransmission.

One of the unique features of GASK1B is its ability to activate its downstream target, Ku7012, which is a GPCR that is involved in the regulation of insulin secretion. This is remarkable, as GASK1B is not a known insulin receptor. Instead, it appears to regulate the activity of the pancreatic beta-cells, which are responsible for producing insulin.

GASK1B has also been shown to play a role in the regulation of appetite and body weight. It has been shown to interact with the satiety hormone, leptin, and to regulate the expression of genes involved in energy metabolism.

GASK1B is also of interest because it has been implicated in the development and progression of various diseases, including obesity, type 2 diabetes, and neurodegenerative disorders. It has been shown to be overexpressed in various tissues, including obesity, and to be involved in the regulation of cellular processes that are associated with these diseases.

In addition to its potential clinical applications, GASK1B is also of interest to researchers because of its unique structure and biochemical properties. The catalytic alpha-helices and long conserved cytoplasmic tail of GASK1B make it an unusual protein, and its ability to regulate the activity of Ku7012 suggests that it has unique mechanisms of action.

GASK1B is a drug target that has the potential to be a valuable tool for the development of new therapies for a variety of diseases. Further research is needed to fully understand its unique mechanisms of action and its potential as a therapeutic target.

Protein Name: Golgi Associated Kinase 1B

The "GASK1B Target / Biomarker Review Report" is a customizable review of hundreds up to thousends of related scientific research literature by AI technology, covering specific information about GASK1B comprehensively, including but not limited to:
•   general information;
•   protein structure and compound binding;
•   protein biological mechanisms;
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•   the target screening and validation;
•   expression level;
•   disease relevance;
•   drug resistance;
•   related combination drugs;
•   pharmacochemistry experiments;
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•   advantages and risks of development, etc.
The report is helpful for project application, drug molecule design, research progress updates, publication of research papers, patent applications, etc. If you are interested to get a full version of this report, please feel free to contact us at BD@silexon.ai

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