Target Name: ZNF451
NCBI ID: G26036
Review Report on ZNF451 Target / Biomarker Content of Review Report on ZNF451 Target / Biomarker
ZNF451
Other Name(s): KIAA0576 | coactivator for steroid receptors | dJ417I1.1 | KIAA1702 | ZNF451 variant 1 | ZATT | FLJ23421 | FLJ53246 | ZN451_HUMAN | FLJ90693 | Coactivator for steroid receptors | OTTHUMP00000016663 | Zinc finger protein 451, transcript variant 3 | E3 SUMO-protein ligase ZNF451 | ZNF451 variant 3 | E3 SUMO-protein ligase ZNF451 (isoform 3) | DJ417I1.1 | Zinc finger protein 451, transcript variant 1 | E3 SUMO-protein ligase ZNF451 (isoform 1) | E3 SUMO-protein transferase ZNF451 | zinc finger protein 451 | Zinc finger protein 451 | zinc finger protein associated with TDP2 and TOP2 | COASTER | MGC26701

ZNF451: A Potential Drug Target and Biomarker

ZNF451 (KIAA0576) is a protein that is expressed in various tissues of the body, including the brain, heart, and kidneys. It is a key regulator of neural development and has been implicated in a number of diseases, including cancer, neurodegenerative diseases, and autoimmune disorders.

One of the most promising aspects of ZNF451 is its potential as a drug target. ZNF451 has been shown to play a role in a variety of cellular processes that are important for disease development, including cell signaling, apoptosis (programmed cell death), and inflammation. It has also been shown to interact with a number of different proteins, including TGF-β1, PDGF, and NF-kappa-B.

ZNF451 has also been shown to be involved in a number of diseases and disorders, including cancer, neurodegenerative diseases, and autoimmune disorders. For example, studies have shown that high levels of ZNF451 are associated with an increased risk of certain types of cancer, such as lung and ovarian cancer. Additionally, ZNF451 has been implicated in a number of neurodegenerative diseases, including Alzheimer's disease and Parkinson's disease.

In addition to its potential as a drug target, ZNF451 is also of interest as a biomarker. Because it is expressed in a variety of tissues and is involved in a number of cellular processes, ZNF451 has been shown to be a potential biomarker for a variety of diseases, including cancer, neurodegenerative diseases, and autoimmune disorders.

One of the challenges in studying ZNF451 as a drug target is its complexity. ZNF451 is involved in a number of different cellular processes and has interactions with a variety of different proteins. This makes it difficult to understand how it works and how it can be targeted by drugs.

In addition to its potential as a drug target, ZNF451 is also of interest as a biomarker. Because it is expressed in a variety of tissues and is involved in a number of cellular processes, ZNF451 has been shown to be a potential biomarker for a variety of diseases, including cancer, neurodegenerative diseases, and autoimmune disorders.

Overall, ZNF451 is a protein that is worth further investigation as a potential drug target and biomarker. Because it is involved in a variety of cellular processes and has been implicated in a number of diseases, ZNF451 has the potential to be a valuable tool for the development of new treatments.

Protein Name: Zinc Finger Protein 451

Functions: E3 SUMO-protein ligase; has a preference for SUMO2 and SUMO3 and facilitates UBE2I/UBC9-mediated sumoylation of target proteins (PubMed:26524493, PubMed:26524494). Plays a role in protein SUMO2 modification in response to stress caused by DNA damage and by proteasome inhibitors (in vitro). Required for MCM4 sumoylation (By similarity). Has no activity with SUMO1 (PubMed:26524493). Preferentially transfers an additional SUMO2 chain onto the SUMO2 consensus site 'Lys-11' (PubMed:26524493). Negatively regulates transcriptional activation mediated by the SMAD4 complex in response to TGF-beta signaling. Inhibits EP300-mediated acetylation of histone H3 at 'Lys-9' (PubMed:24324267). Plays a role in regulating the transcription of AR targets (PubMed:18656483)

The "ZNF451 Target / Biomarker Review Report" is a customizable review of hundreds up to thousends of related scientific research literature by AI technology, covering specific information about ZNF451 comprehensively, including but not limited to:
•   general information;
•   protein structure and compound binding;
•   protein biological mechanisms;
•   its importance;
•   the target screening and validation;
•   expression level;
•   disease relevance;
•   drug resistance;
•   related combination drugs;
•   pharmacochemistry experiments;
•   related patent analysis;
•   advantages and risks of development, etc.
The report is helpful for project application, drug molecule design, research progress updates, publication of research papers, patent applications, etc. If you are interested to get a full version of this report, please feel free to contact us at BD@silexon.ai

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