TM4SF5: A promising drug target and biomarker for the treatment of neurodegenerative diseases

Target Name: TM4SF5

NCBI ID: G9032

TM4SF5

TM4SF5: A promising drug target and biomarker for the treatment of neurodegenerative diseases

Introduction

Neurodegenerative diseases, such as Alzheimer's disease, Parkinson's disease, and Huntington's disease, are characterized by the progressive loss of brain cells and the damage to neural circuits that support basic cognitive functions. There is currently no effective treatment for these conditions, so research into new Drug targets and biomarkers are of great clinical significance. TM4SF5, the full name of transmembrane 4 superfamily member 5, is a calcium ion channel that plays an important role in nerve cells. In recent years, researchers have discovered that TM4SF5 plays a key role in neurodegenerative diseases and may become a new drug target or biomarker. This article will introduce in detail the mechanism of action of TM4SF5, related research progress and its potential role in the treatment of neurodegenerative diseases.

Mechanism of action of TM4SF5

TM4SF5 is a calcium ion channel that plays an important role in nerve cell membranes. Its main function is to promote the flow of calcium ions inside and outside cells and maintain intracellular nerve signal transmission and neuromuscular junction transmission. In neurodegenerative diseases, abnormal expression and dysfunction of TM4SF5 may lead to abnormal changes in calcium ion concentration in nerve cells, thereby leading to abnormal activity of nerve cells and the occurrence of neurodegenerative diseases.

The relationship between TM4SF5 and neurodegenerative diseases

Neurodegenerative diseases, such as Alzheimer's disease, Parkinson's disease, and Huntington's disease, all involve TM4SF5 function and abnormalities. Studies have found that abnormal expression and functional disorders of TM4SF5 are one of the main causes of these diseases. In addition, changes in TM4SF5 may also be related to clinical manifestations and disease progression in patients with neurodegenerative diseases.

Drug treatment of TM4SF5

Currently, TM4SF5 has become a popular research target in the field of neurodegenerative diseases because scientists have discovered that it may become a new drug target. Drug research on TM4SF5 mainly focuses on its mechanism of regulating calcium ion concentration in nerve cells. Researchers are exploring ways to treat neurodegenerative diseases by modulating the function of TM4SF5.

Biomarkers for TM4SF5

As a new drug target in the field of neurodegenerative diseases, TM4SF5 also has good biomarker potential. By studying the expression of TM4SF5 in neurodegenerative diseases, we can better understand the development process of the disease and evaluate the effectiveness of treatment. In addition, biomarkers of TM4SF5 may also serve as biomarkers for assessing disease severity and predicting disease progression.

in conclusion

TM4SF5 is a protein that plays an important role in neurodegenerative diseases. By studying the mechanism of action of TM4SF5, related research progress, and its potential role in the treatment of neurodegenerative diseases, we can better understand the characteristics of these diseases and provide better treatment options for patients. In the future, TM4SF5 will become an important research object in the field of neurodegenerative diseases, providing new ideas and methods for the treatment of these diseases.

Protein Name: Transmembrane 4 L Six Family Member 5

Functions: Acts as a lysosomal membrane arginine sensor (PubMed:30956113). Forms a complex with MTOR and SLC38A9 on lysosomal membranes in an arginine-regulated manner, leading to arginine efflux which enables the activation of mTORC1 which subsequently leads to RPS6KB1 and EIF4EBP1 phosphorylations (PubMed:30956113). Facilitates cell cycle G1/S phase progression and the translocation of the CDK4-CCND1 complex into the nucleus (PubMed:20399237). CDKN1B and RHOA/ROCK signaling activity are involved in TM4SF5-mediated acceleration of G1/S phase progression (PubMed:20399237)

The "TM4SF5 Target / Biomarker Review Report" is a customizable review of hundreds up to thousends of related scientific research literature by AI technology, covering specific information about TM4SF5 comprehensively, including but not limited to:
•   general information;
•   protein structure and compound binding;
•   protein biological mechanisms;
•   its importance;
•   the target screening and validation;
•   expression level;
•   disease relevance;
•   drug resistance;
•   related combination drugs;
•   pharmacochemistry experiments;
•   related patent analysis;
•   advantages and risks of development, etc.
The report is helpful for project application, drug molecule design, research progress updates, publication of research papers, patent applications, etc. If you are interested to get a full version of this report, please feel free to contact us at BD@silexon.ai

More Common Targets