TMCC1: A Potential Drug Target and Biomarker in Transmembrane and Coiled-Coil Domain Family 1

Target Name: TMCC1

NCBI ID: G23023

TMCC1

TMCC1: A Potential Drug Target and Biomarker in Transmembrane and Coiled-Coil Domain Family 1

Transmembrane and coiled-coil domain families play a crucial role in the diverse physiological processes that occur in the cell. These families are involved in various cellular processes, including signal transduction, intracellular transport, and cell-cell communication.TMCC1, a member of the transmembrane and coiled-coil domain family 1, has been identified as a potential drug target and biomarker. This article will provide an overview of TMCC1, its functions, and potential therapeutic applications.

Background

TMCC1 is a protein that belongs to the transmembrane and coiled-coil domain family 1. This family is characterized by the presence of a transmembrane domain and a coiled-coil domain.TMCC1 is a 21-kDa protein that is expressed in various cell types, including neurons, heart cells, and lens cells. It is involved in various cellular processes, including the regulation of ion channels, protein-protein interactions, and intracellular signaling pathways.

Function

TMCC1 functions as a negative regulator of the Shc/FAK-associated protein (FAK), which is involved in cell signaling, cell adhesion, and survival. TMCC1 plays a critical role in the regulation of ion channels, including the management of action potentials (APs) in neurons and muscle cells. It is also involved in the regulation of protein-protein interactions, including the interaction between TMCC1 and the protein p120GTP.

TMCC1 has been shown to play a negative role in the regulation of cell survival and proliferation. It has been shown to enhance the inhibition of FAK-associated signaling pathways, which can lead to the survival and proliferation of cancer cells. TMCC1 has also been shown to promote the growth and survival of neuronal cells, which may have implications for the development of neurodegenerative diseases.

Potential Therapeutic Applications

TMCC1 has the potential to serve as a drug target for various diseases, including cancer, neurodegenerative diseases, and chronic pain. Its functions in the regulation of ion channels, protein-protein interactions, and cell signaling pathways make it an attractive target for the development of new therapeutic agents.

In the context of cancer, TMCC1 has been shown to promote the survival and proliferation of various cancer cell types. Its regulation of FAK-associated signaling pathways may contribute to the development of resistance to chemotherapy in cancer cells. TMCC1 may also be a useful target for the development of new anti-cancer drugs that target its functions in the regulation of ion channels and protein-protein interactions.

In the context of neurodegenerative diseases, TMCC1 may play a role in the regulation of ion channels and neurotransmitter signaling pathways. Its functions in these areas may contribute to the development of neurodegenerative diseases, including Alzheimer's disease, Parkinson's disease, and Huntington's disease. TMCC1 may also be a useful target for the development of new neurodegenerative disease therapies that target its functions in the regulation of ion channels and protein-protein interactions.

In the context of chronic pain, TMCC1 may play a role in the regulation of pain signaling pathways. Its functions in these areas may contribute to the development and maintenance of chronic pain. TMCC1 may also be a useful target for the development of new chronic pain therapies that target its functions in the regulation of pain signaling pathways.

Conclusion

TMCC1 is a protein that functions as a negative regulator of the Shc/FAK-associated protein (FAK), which is involved in various cellular processes. Its regulation of ion channels, protein-protein interactions, and cell signaling pathways makes it a potential drug target for the development of new therapeutic agents for various diseases, including cancer, neurodegenerative diseases, and chronic pain. Further research is needed to fully understand the functions of TMCC1 and its potential as a drug

Protein Name: Transmembrane And Coiled-coil Domain Family 1

Functions: Endoplasmic reticulum membrane protein that promotes endoplasmic reticulum-associated endosome fission (PubMed:30220460). Localizes to contact sites between the endoplasmic reticulum and endosomes and acts by promoting recruitment of the endoplasmic reticulum to endosome tubules for fission (PubMed:30220460). Endosome membrane fission of early and late endosomes is essential to separate regions destined for lysosomal degradation from carriers to be recycled to the plasma membrane (PubMed:30220460)

The "TMCC1 Target / Biomarker Review Report" is a customizable review of hundreds up to thousends of related scientific research literature by AI technology, covering specific information about TMCC1 comprehensively, including but not limited to:
•   general information;
•   protein structure and compound binding;
•   protein biological mechanisms;
•   its importance;
•   the target screening and validation;
•   expression level;
•   disease relevance;
•   drug resistance;
•   related combination drugs;
•   pharmacochemistry experiments;
•   related patent analysis;
•   advantages and risks of development, etc.
The report is helpful for project application, drug molecule design, research progress updates, publication of research papers, patent applications, etc. If you are interested to get a full version of this report, please feel free to contact us at BD@silexon.ai

More Common Targets