TMCO1: A Potential Drug Target and Biomarker (G54499)

Target Name: TMCO1

NCBI ID: G54499

TMCO1

TMCO1: A Potential Drug Target and Biomarker

Telomere maintenance and repair processes are crucial for the survival and function of all living organisms. As we age, the telomeres on our chromosomes shorten, leading to the onset of various age-related diseases, including cancer, neurodegenerative diseases, and cardiovascular diseases. Therefore, identifying potential drug targets and biomarkers for telomeres is of great interest and importance. One such potential drug target and biomarker is TMCO1, which is a protein that is involved in the telomere maintenance and repair processes.

TMCO1 is a protein that is expressed in all human tissues and is highly conserved across various species. It is a member of the Telomere Maintenance Complex (TMC), which is a protein complex that plays a crucial role in maintaining telomeres. The TMC is composed of multiple proteins that work together to prevent the shortening of telomeres and ensure their stability. TMCO1 is one of the key proteins in this complex and is responsible for the regulation of telomere maintenance and repair.

TMCO1 functions as a negative regulator of the telomerase enzyme, which is responsible for maintaining and repairing telomeres. Telomerase is a protein that protects the ends of telomeres by repetitive DNA sequences, which are called telomeres. When telomerase is active, it expands the telomeres by adding repetitive DNA sequences at their ends. However, when telomerase is not active, TMCO1 accumulates at the telomere ends and prevents them from being shortened. This process is crucial for the maintenance of telomeres and the age-related diseases that result from their shortening.

TMCO1's role in telomere maintenance and repair is supported by several experimental data. For example, studies have shown that TMCO1 accumulates at the telomere ends in older individuals and that this accumulation is associated with the shortening of telomeres and the onset of age-related diseases. Additionally, experiments have shown that TMCO1 levels are elevated in various age-related diseases, including cancer, neurodegenerative diseases, and cardiovascular diseases.

TMCO1 is also a potential biomarker for age-related diseases. Its accumulation at telomere ends is a hallmark of aging, and its levels are often elevated in individuals over age 50. Therefore, TMCO1 may be a useful biomarker for age-related diseases, including cancer, neurodegenerative diseases, and cardiovascular diseases.

In conclusion, TMCO1 is a protein that is involved in the telomere maintenance and repair processes. Its role in these processes is crucial for the survival and function of all living organisms. Therefore, identifying potential drug targets and biomarkers for TMCO1 is of great interest and importance. Further research is needed to fully understand the role of TMCO1 in telomere maintenance and repair and to develop effective treatments for age-related diseases.

Protein Name: Transmembrane And Coiled-coil Domains 1

Functions: Calcium-selective channel required to prevent calcium stores from overfilling, thereby playing a key role in calcium homeostasis (PubMed:27212239). In response to endoplasmic reticulum (ER) overloading, assembles into a homotetramer, forming a functional calcium-selective channel, regulating the calcium content in endoplasmic reticulum store (PubMed:27212239). Component of the multi-pass translocon (MPT) complex that mediates insertion of multi-pass membrane proteins into the lipid bilayer of membranes (PubMed:32820719, PubMed:36261522). The MPT complex takes over after the SEC61 complex: following membrane insertion of the first few transmembrane segments of proteins by the SEC61 complex, the MPT complex occludes the lateral gate of the SEC61 complex to promote insertion of subsequent transmembrane regions (PubMed:36261522). Within the MPT complex, the GEL subcomplex may mediate insertion of transmembrane regions into the membrane (PubMed:36261522)

The "TMCO1 Target / Biomarker Review Report" is a customizable review of hundreds up to thousends of related scientific research literature by AI technology, covering specific information about TMCO1 comprehensively, including but not limited to:
•   general information;
•   protein structure and compound binding;
•   protein biological mechanisms;
•   its importance;
•   the target screening and validation;
•   expression level;
•   disease relevance;
•   drug resistance;
•   related combination drugs;
•   pharmacochemistry experiments;
•   related patent analysis;
•   advantages and risks of development, etc.
The report is helpful for project application, drug molecule design, research progress updates, publication of research papers, patent applications, etc. If you are interested to get a full version of this report, please feel free to contact us at BD@silexon.ai

More Common Targets