TLR8: A Promising Drug Target for A Wide Range of Diseases (G51311)

Target Name: TLR8

NCBI ID: G51311

TLR8

TLR8: A Promising Drug Target for A Wide Range of Diseases

Toll-like receptor 8 (TLR8) is a protein that is expressed in many different tissues throughout the body. It is a type of immune receptor that is involved in the innate immune system, which is the body's first line of defense against infection. TLR8 is a critical regulator of the immune response and has been implicated in a number of diseases, including autoimmune disorders, cancer, and obesity.

One of the things that makes TLR8 such a promising drug target is its location on the cell surface. TLR8 is expressed in the cytoplasm of most cell types, which makes it relatively easy to target with small molecules. Additionally, TLR8 is a protein that is highly conserved across many different species, which means that it is likely to have similar structures and functions in different organisms.

TLR8 is involved in a number of different signaling pathways in the immune system. It is a key regulator of the production of dendritic cells, which are a type of immune cell that are responsible for presenting antigens to T cells. TLR8 also plays a role in the regulation of inflammation and immune cell function.

One of the things that makes TLR8 so important for understanding the immune system is its role in the regulation of autoimmune disorders. Autoimmune disorders occur when the immune system attacks the body's own tissues, leading to inflammation and damage. TLR8 is involved in the regulation of the immune response in the regulation of autoimmune disorders.

In addition to its role in autoimmune disorders, TLR8 is also involved in the regulation of cancer. Studies have shown that TLR8 is involved in the regulation of cancer cell growth and the development of cancer. TLR8 has also been shown to play a role in the regulation of cell death, which may help to explain its involvement in cancer.

In addition to its involvement in autoimmune disorders and cancer, TLR8 is also involved in the regulation of obesity. Obesity is a condition in which the body stores too much fat, leading to a number of health problems. TLR8 is involved in the regulation of the immune response in the regulation of obesity.

One of the things that makes TLR8 such an attractive drug target is its potential to treat a wide range of diseases. Its involvement in the immune system and its relatively simple structure make it a promising candidate for a variety of treatments. Additionally, TLR8 is not just a protein that is involved in the immune system, but it is also involved in the regulation of a wide range of cellular processes, which makes it a potentially more versatile drug target.

In conclusion, TLR8 is a protein that is involved in the innate immune system and has been implicated in a number of diseases, including autoimmune disorders, cancer, and obesity. Its location on the cell surface and its relatively simple structure make it a promising candidate for a variety of treatments. Further research is needed to fully understand the role of TLR8 in the immune system and its potential as a drug target.

Protein Name: Toll Like Receptor 8

Functions: Endosomal receptor that plays a key role in innate and adaptive immunity (PubMed:25297876, PubMed:32433612). Controls host immune response against pathogens through recognition of RNA degradation products specific to microorganisms that are initially processed by RNASET2 (PubMed:31778653). Recognizes GU-rich single-stranded RNA (GU-rich RNA) derived from SARS-CoV-2, SARS-CoV-1 and HIV-1 viruses (PubMed:33718825). Upon binding to agonists, undergoes dimerization that brings TIR domains from the two molecules into direct contact, leading to the recruitment of TIR-containing downstream adapter MYD88 through homotypic interaction (PubMed:23520111, PubMed:25599397, PubMed:26929371, PubMed:33718825). In turn, the Myddosome signaling complex is formed involving IRAK4, IRAK1, TRAF6, TRAF3 leading to activation of downstream transcription factors NF-kappa-B and IRF7 to induce pro-inflammatory cytokines and interferons, respectively (PubMed:16737960, PubMed:17932028, PubMed:29155428)

The "TLR8 Target / Biomarker Review Report" is a customizable review of hundreds up to thousends of related scientific research literature by AI technology, covering specific information about TLR8 comprehensively, including but not limited to:
•   general information;
•   protein structure and compound binding;
•   protein biological mechanisms;
•   its importance;
•   the target screening and validation;
•   expression level;
•   disease relevance;
•   drug resistance;
•   related combination drugs;
•   pharmacochemistry experiments;
•   related patent analysis;
•   advantages and risks of development, etc.
The report is helpful for project application, drug molecule design, research progress updates, publication of research papers, patent applications, etc. If you are interested to get a full version of this report, please feel free to contact us at BD@silexon.ai

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