Understanding The Metabolism of Cobalamin Associated D (G27249)

Target Name: MMADHC

NCBI ID: G27249

MMADHC

Understanding The Metabolism of Cobalamin Associated D

Metabolism of cobalamin associated D (MMADHC) is a drug target and a biomarker that has been gaining attention in recent years due to its crucial role in various biological processes. Cobalamin associated D, also known as cobalamin D, is a metabolite of the vitamin B12 (cobalamin) that is involved in the metabolism of DNA, RNA, and proteins. It has been shown to have various functions in the human body, including maintaining cellular health, supporting immune system function, and regulating inflammation.

The metabolism of cobalamin associated D is complex and involves multiple pathways. One of the well-known pathways involves the oxidative N-dealkylation of the carbon atom of cobalamin associated D by enzymes such as HDACs (hairless and dimethylmercurial acid-converting enzymes) and DNA methyltransferases (DNMTs). This N-dealkylation process gives rise to various metabolites, including 6-dehydro-cobalamin associated D (6-DCD), which is a potent metabolite with neuroprotective properties.

6-DCD has been shown to have neuroprotective properties, including its ability to protect against oxidative stress, neurotoxicity, and inflammation. It has also been shown to modulate various cellular signaling pathways, including the production of reactive oxygen species (ROS) and the production of inflammatory cytokines. Additionally, 6-DCD has been shown to interact with various protein targets, including the neurotransmitter receptor N-methyl-D-aspartate (NMDA).

The role of 6-DCD in the regulation of cellular processes also extends to the regulation of inflammation. Chronic inflammation has been associated with various diseases, including cancer, neurodegenerative diseases, and autoimmune diseases. 6-DCD has been shown to have a role in the regulation of inflammatory responses by modulating the activity of immune cells such as T cells, B cells, and macrophages.

6-DCD has also been shown to have a role in the regulation of cellular aging. Aging is associated with various diseases, including cancer, neurodegenerative diseases, and cardiovascular diseases. 6-DCD has been shown to have a role in the regulation of cellular aging by modulating the activity of genes involved in cellular stress response, DNA damage repair, and apoptosis.

In conclusion, metabolite of cobalamin associated D (MMADHC) is a drug target and a biomarker with various functions in the human body. Its complex metabolism and neuroprotective properties make it an attractive target for drug development. Further research is needed to fully understand the role of MMADHC in the regulation of cellular processes and its potential as a therapeutic agent.

Protein Name: Metabolism Of Cobalamin Associated D

Functions: Involved in cobalamin metabolism and trafficking (PubMed:18385497, PubMed:23415655, PubMed:24722857, PubMed:26364851). Plays a role in regulating the biosynthesis and the proportion of two coenzymes, methylcob(III)alamin (MeCbl) and 5'-deoxyadenosylcobalamin (AdoCbl) (PubMed:18385497, PubMed:23415655, PubMed:24722857). Promotes oxidation of cob(II)alamin bound to MMACHC (PubMed:26364851). The processing of cobalamin in the cytosol occurs in a multiprotein complex composed of at least MMACHC, MMADHC, MTRR (methionine synthase reductase) and MTR (methionine synthase) which may contribute to shuttle safely and efficiently cobalamin towards MTR in order to produce methionine (PubMed:27771510)

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