MORF4L1-AS1: A Promising Drug Target for Various Diseases (G10933)

Target Name: MORF4L1

NCBI ID: G10933

MORF4L1

MORF4L1-AS1: A Promising Drug Target for Various Diseases

MORF4L1 (MORF4-like 1) is a gene that encodes a protein known as MORF4L1-AS1. MORF4L1-AS1 is a transmembrane protein that is expressed in various tissues, including brain, heart, and muscle. It is characterized by a unique extracellular domain that consists of a catalytic center and a long N-terminal region.

MORF4L1-AS1 functions as a negative regulator of the Wnt signaling pathway, which is a critical pathway involved in cell-to-cell and cell-to-environmental communication. The Wnt signaling pathway plays a crucial role in the development, maintenance, and regulation of various tissues and organs, including the nervous system.

MORF4L1-AS1 is a potential drug target for various diseases, including cancer, neurodegenerative diseases, and autoimmune disorders. Its unique function as a negative regulator of the Wnt signaling pathway makes it an attractive target for researchers who are seeking new treatments for these diseases.

One of the reasons why MORF4L1-AS1 is a promising drug target is its unique structure and function. Its catalytic center, which is located at the N-terminus of the protein, is known for its ability to catalyze various chemical reactions, including the hydrolysis of intracellular signaling molecules. This unique function of MORF4L1-AS1 makes it a potential target for small molecules that can inhibit its catalytic activity.

In addition, MORF4L1-AS1 is also characterized by a long N-terminal region that is involved in various signaling pathways. This region has been shown to play a role in the regulation of cell adhesion, migration, and invasion. Therefore, drugs that can modulate these signaling pathways may also be effective in targeting MORF4L1-AS1.

Another reason why MORF4L1-AS1 is a promising drug target is its expression in various tissues. MORF4L1-AS1 is expressed in a wide range of tissues, including brain, heart, and muscle. This makes it an attractive target for drugs that can modulate its expression or activity in specific tissues. For example, drugs that can inhibit the activity of MORF4L1-AS1 in specific tissues, such as cancer cells or neurodegenerative cells, may have therapeutic benefits in treating these diseases.

In conclusion, MORF4L1-AS1 is a unique protein with a potential as a drug target. Its catalytic center and long N-terminal region make it an attractive target for small molecules that can inhibit its function. Its expression in various tissues also makes it a promising target for drugs that can modulate its expression or activity in specific tissues. Further research is needed to determine the full potential of MORF4L1-AS1 as a drug target and to develop effective treatments for diseases that are caused by its dysfunction.

Protein Name: Mortality Factor 4 Like 1

Functions: Component of the NuA4 histone acetyltransferase (HAT) complex which is involved in transcriptional activation of select genes principally by acetylation of nucleosomal histones H4 and H2A. This modification may both alter nucleosome - DNA interactions and promote interaction of the modified histones with other proteins which positively regulate transcription. This complex may be required for the activation of transcriptional programs associated with oncogene and proto-oncogene mediated growth induction, tumor suppressor mediated growth arrest and replicative senescence, apoptosis, and DNA repair. The NuA4 complex ATPase and helicase activities seem to be, at least in part, contributed by the association of RUVBL1 and RUVBL2 with EP400. NuA4 may also play a direct role in DNA repair when directly recruited to sites of DNA damage. Also a component of the mSin3A complex which acts to repress transcription by deacetylation of nucleosomal histones. Required for homologous recombination repair (HRR) and resistance to mitomycin C (MMC). Involved in the localization of PALB2, BRCA2 and RAD51, but not BRCA1, to DNA-damage foci

The "MORF4L1 Target / Biomarker Review Report" is a customizable review of hundreds up to thousends of related scientific research literature by AI technology, covering specific information about MORF4L1 comprehensively, including but not limited to:
•   general information;
•   protein structure and compound binding;
•   protein biological mechanisms;
•   its importance;
•   the target screening and validation;
•   expression level;
•   disease relevance;
•   drug resistance;
•   related combination drugs;
•   pharmacochemistry experiments;
•   related patent analysis;
•   advantages and risks of development, etc.
The report is helpful for project application, drug molecule design, research progress updates, publication of research papers, patent applications, etc. If you are interested to get a full version of this report, please feel free to contact us at BD@silexon.ai

More Common Targets