MMP16: A Potential Drug Target and Biomarker (G4325)

Target Name: MMP16

NCBI ID: G4325

MMP16

MMP16: A Potential Drug Target and Biomarker

MMP16 (Mesothelin-derived peptide 16) is a protein that is expressed in various tissues throughout the body, including the skin, heart, and lungs. It is a member of the transmembrane protein family, which means that it spans the cell membrane and extends into the space between cells.

MMP16 has been identified as a potential drug target or biomarker due to its unique structure and various biological functions. One of the key features of MMP16 is its ability to interact with various signaling molecules, including TGF-β1, a well-known growth factor that plays a critical role in cell growth and development.

TGF-β1 is known for its ability to promote the formation of new blood vessels, which can lead to increased blood flow and improved oxygenation of tissues. This can be useful for treating a variety of conditions, including cancer, wound healing, and skin disorders.

MMP16 has also been shown to interact with the protein PDGF-BB, which is a critical signaling molecule that plays a role in tissue repair and regeneration. This interaction between MMP16 and PDGF-BB suggests that MMP16 may have potential as a therapeutic agent for diseases that involve tissue repair or regeneration, such as cancer or wound healing.

Another potential function of MMP16 is its role in cell adhesion. MMP16 is a member of the cadherin family of transmembrane proteins, which are responsible for maintaining the integrity of cell membranes and for cell-cell adhesion. This function is important for the proper functioning of many tissues, including the heart, where cell-cell adhesion is critical for maintaining the heart's rhythm and structure.

MMP16 has also been shown to play a role in the regulation of pain. Studies have shown that MMP16 is involved in the production of pain signals, which can help to alert the brain and body of potential injuries or threats. This function may make MMP16 an attractive target for drugs that are designed to alleviate pain.

In addition to its potential drug-targeting and biomarker properties, MMP16 is also of interest to researchers due to its unique structure and biology. MMP16 is made up of a series of 16 amino acid residues that are arranged in a specific sequence. This sequence is conserved across various species, which suggests that MMP16 may have a role in the evolution of new tissues or organs.

Overall, MMP16 is a protein that has a unique structure and biology that makes it an attractive candidate for drug targeting or biomarker development. Further research is needed to fully understand its functions and potential as a therapeutic agent.

Protein Name: Matrix Metallopeptidase 16

Functions: Endopeptidase that degrades various components of the extracellular matrix, such as collagen type III and fibronectin. Activates progelatinase A. Involved in the matrix remodeling of blood vessels. Isoform short cleaves fibronectin and also collagen type III, but at lower rate. It has no effect on type I, II, IV and V collagen. However, upon interaction with CSPG4, it may be involved in degradation and invasion of type I collagen by melanoma cells

The "MMP16 Target / Biomarker Review Report" is a customizable review of hundreds up to thousends of related scientific research literature by AI technology, covering specific information about MMP16 comprehensively, including but not limited to:
•   general information;
•   protein structure and compound binding;
•   protein biological mechanisms;
•   its importance;
•   the target screening and validation;
•   expression level;
•   disease relevance;
•   drug resistance;
•   related combination drugs;
•   pharmacochemistry experiments;
•   related patent analysis;
•   advantages and risks of development, etc.
The report is helpful for project application, drug molecule design, research progress updates, publication of research papers, patent applications, etc. If you are interested to get a full version of this report, please feel free to contact us at BD@silexon.ai

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