MOV10: Regulating Cellular Processes in The Brain (G4343)

Target Name: MOV10

NCBI ID: G4343

MOV10

MOV10: Regulating Cellular Processes in The Brain

MOV10 (MOV10 variant 3) is a protein that is expressed in various tissues of the body, including the brain, heart, and kidneys. It is a member of the MOV family of proteins, which are known for their role in intracellular signaling. MOV10 has been shown to play a role in the regulation of cellular processes that are important for brain development and function, such as cell migration, neurogenesis, and neuroprotection.

MOV10 is a 120-kDa protein that is expressed in the brain, heart, and kidneys. It is localized to the endoplasmic reticulum (ER) and can be processed and degraded by endoplasmic reticulum-associated degradation (ERAD). MOV10 is also known as MOV10 variant 3 because it is one of several isoforms of the MOV10 gene that have been identified.

MOV10 has been shown to play a role in the regulation of cellular processes that are important for brain development and function. One of the functions of MOV10 is to regulate the movement of cells, both in the brain and in other tissues. MOV10 has been shown to play a role in the regulation of cell migration, which is the process by which cells move from one location to another in the body. MOV10 has been shown to use a mechanism called synaptophysin-mediated endocytosis to regulate the movement of neurons in the brain.

Another function of MOV10 is to regulate the production of neurotransmitters, such as dopamine and serotonin, which are important for brain function. MOV10 has been shown to play a role in the regulation of neurotransmitter release by using a mechanism called protein kinase C (PKC)-mediated signaling. MOV10 has been shown to interact with the protein Pyruvate Kinase (PK), which is involved in the regulation of neurotransmitter production.

MOV10 has also been shown to play a role in the regulation of cellular stress responses, which are important for maintaining cellular homeostasis. Stress can cause damage to cells, and MOV10 has been shown to play a role in the regulation of cellular stress responses by using a mechanism called calorie homeostasis. MOV10 has been shown to interact with the protein heat shock protein (Hsp)70, which is involved in the regulation of cellular stress responses.

MOV10 has also been shown to play a role in the regulation of cellular apoptosis, which is the process by which cells die when they have been damaged or are no longer needed. MOV10 has been shown to play a role in the regulation of cellular apoptosis by using a mechanism called caspase-3-mediated signaling. MOV10 has been shown to interact with the protein Bax, which is involved in the regulation of cellular apoptosis.

MOV10 has also been shown to play a role in the regulation of the blood-brain barrier (BBB), which is a barrier that separates the brain from the bloodstream. The BBB helps to protect the brain from harmful substances that could enter the brain, but it also allows certain substances to come into the brain. MOV10 has been shown to play a role in the regulation of the BBB by using a mechanism called FAK-mediated signaling. MOV10 has been shown to interact with the proteinFAK, which is involved in the regulation of the BBB.

In conclusion, MOV10 is a protein that has been shown to play a role in the regulation of various cellular processes that are important for

Protein Name: Mov10 RISC Complex RNA Helicase

Functions: 5' to 3' RNA helicase that is involved in a number of cellular roles ranging from mRNA metabolism and translation, modulation of viral infectivity, inhibition of retrotransposition, or regulation of synaptic transmission (PubMed:23093941). Plays an important role in innate antiviral immunity by promoting type I interferon production (PubMed:27016603, PubMed:35157734, PubMed:27974568). Mechanistically, specifically uses IKKepsilon/IKBKE as the mediator kinase for IRF3 activation (PubMed:27016603, PubMed:35157734). Blocks HIV-1 virus replication at a post-entry step (PubMed:20215113). Counteracts HIV-1 Vif-mediated degradation of APOBEC3G through its helicase activity by interfering with the ubiquitin-proteasome pathway (PubMed:29258557). Inhibits also hepatitis B virus/HBV replication by interacting with HBV RNA and thereby inhibiting the early step of viral reverse transcription (PubMed:31722967). Contributes to UPF1 mRNA target degradation by translocation along 3' UTRs (PubMed:24726324). Required for microRNA (miRNA)-mediated gene silencing by the RNA-induced silencing complex (RISC). Required for both miRNA-mediated translational repression and miRNA-mediated cleavage of complementary mRNAs by RISC (PubMed:16289642, PubMed:17507929, PubMed:22791714). In cooperation with FMR1, regulates miRNA-mediated translational repression by AGO2 (PubMed:25464849). Restricts retrotransposition of long interspersed element-1 (LINE-1) in cooperation with TUT4 and TUT7 counteracting the RNA chaperonne activity of L1RE1 (PubMed:30122351, PubMed:23093941). Facilitates LINE-1 uridylation by TUT4 and TUT7 (PubMed:30122351). Required for embryonic viability and for normal central nervous system development and function. Plays two critical roles in early brain development: suppresses retroelements in the nucleus by directly inhibiting cDNA synthesis, while regulates cytoskeletal mRNAs to influence neurite outgrowth in the cytosol (By similarity). May function as a messenger ribonucleoprotein (mRNP) clearance factor (PubMed:24726324)

The "MOV10 Target / Biomarker Review Report" is a customizable review of hundreds up to thousends of related scientific research literature by AI technology, covering specific information about MOV10 comprehensively, including but not limited to:
•   general information;
•   protein structure and compound binding;
•   protein biological mechanisms;
•   its importance;
•   the target screening and validation;
•   expression level;
•   disease relevance;
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•   related combination drugs;
•   pharmacochemistry experiments;
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•   advantages and risks of development, etc.
The report is helpful for project application, drug molecule design, research progress updates, publication of research papers, patent applications, etc. If you are interested to get a full version of this report, please feel free to contact us at BD@silexon.ai

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