MMP21: A Drug Target / Disease Biomarker (G118856)

Target Name: MMP21

NCBI ID: G118856

MMP21

MMP21: A Drug Target / Disease Biomarker

MMP21 is a protein that is expressed in various tissues throughout the body. It is a member of the integrin family, which is a large superfamily of proteins that are involved in cell-cell and cell-extracellular matrix interactions. MMP21 is known for its role in cell-cell adhesion, as well as its role in the development and progression of various diseases, including cancer.

One of the unique aspects of MMP21 is its ability to induce cell-cell adhesion. This is accomplished through the interaction of MMP21 with its partner protein, ALK3. When MMP21 and ALK3 come into contact, they cause ALK3 to change shape and become more densely packed together. This interaction between MMP21 and ALK3 is critical for the development and maintenance of tight cell-cell adhesion, which is essential for many cellular processes, including tissue repair and regeneration.

In addition to its role in cell-cell adhesion, MMP21 is also involved in the development and progression of various diseases. For example, MMP21 has been shown to be overexpressed in various types of cancer, including breast, ovarian, and colorectal cancers. This increase in MMP21 expression has been associated with the development of cancer-related symptoms, such as the formation of new blood vessels, the growth of tumors, and the spread of cancer to other organs.

Another unique aspect of MMP21 is its ability to induce the formation of new blood vessels. This is accomplished through the regulation of angiogenesis, which is the process by which new blood vessels are formed in response to changes in the levels of growth factors in the body. MMP21 has been shown to play a key role in this process, as it can cause the activation and proliferation of progenitor cells that have the ability to give rise to new blood vessels.

MMP21 is also involved in the regulation of the immune response. It has been shown to play a key role in the development of cancer-related immune evasion, as well as the regulation of immune cell function. MMP21 has been shown to interact with various immune cell types, including T cells, natural killer cells, and B cells. These interactions have the potential to affect the immune response and contribute to the development and progression of cancer.

In conclusion, MMP21 is a protein that is involved in a wide range of cellular processes that are important for the development and maintenance of tissues and organs. Its role in cell-cell adhesion, the regulation of angiogenesis, and the immune response makes it an attractive target for drug development and research into the development and progression of various diseases. Further research is needed to fully understand the mechanisms of MMP21 and its role in these processes.

Protein Name: Matrix Metallopeptidase 21

Functions: Plays a specialized role in the generation of left-right asymmetry during embryogenesis. May act as a negative regulator of the NOTCH-signaling pathway (PubMed:26429889, PubMed:26437028). Cleaves alpha-1-antitrypsin (PubMed:12617721)

The "MMP21 Target / Biomarker Review Report" is a customizable review of hundreds up to thousends of related scientific research literature by AI technology, covering specific information about MMP21 comprehensively, including but not limited to:
•   general information;
•   protein structure and compound binding;
•   protein biological mechanisms;
•   its importance;
•   the target screening and validation;
•   expression level;
•   disease relevance;
•   drug resistance;
•   related combination drugs;
•   pharmacochemistry experiments;
•   related patent analysis;
•   advantages and risks of development, etc.
The report is helpful for project application, drug molecule design, research progress updates, publication of research papers, patent applications, etc. If you are interested to get a full version of this report, please feel free to contact us at BD@silexon.ai

More Common Targets