MMP17: A Potential Drug Target and Biomarker (G4326)

Target Name: MMP17

NCBI ID: G4326

MMP17

MMP17: A Potential Drug Target and Biomarker

MMP17 (Mesothelin-derived peptide 17) is a 21-kDa protein that is synthesized in the cell membrane of many different cell types. It is composed of two distinct domains: a N-terminal domain that is rich in heparan sulfate chains, and a C-terminal domain that contains a heparan sulfate-containing peptide core and several transmembrane domains.

One of the most interesting aspects of MMP17 is its potential as a drug target or biomarker. Several studies have suggested that MMP17 may play a role in various biological processes, including cell signaling, migration, and invasion. In addition, its unique structure has led to the development of several new biomarkers for cancer diagnosis and treatment.

One of the primary functions of MMP17 is its role in cell signaling. It is a key component of the cell-cell adhesion complex, which is responsible for maintaining tissue structure and function. MMP17 functions as a negative regulator of the cadherin protein, which is a major adhesion molecule that plays a crucial role in many different processes in the body.

In addition to its role in cell signaling, MMP17 has also been shown to be involved in cell migration and invasion. It has been shown to promote the migration of cancer cells through the use of several different mechanisms, including the inhibition of the sprouting angiogenesis pathway. In addition, MMP17 has also been shown to contribute to the invasive properties of cancer cells by promoting the formation of cancer cell-associated extracellular matrix (ECM) and promoting the migration of cancer cells through the use of several different mechanisms.

Another potential function of MMP17 is its role as a drug target. Its unique structure and various bioactive peptides have make it an attractive target for drug development. Several studies have shown that MMP17 can be effectively inhibited using small molecules, peptides, and other drug candidates. In addition, several studies have also shown that MMP17 interacts with several different signaling pathways, including the PI3K/Akt signaling pathway, which suggests that it may be a useful target for the development of anti-cancer drugs.

In addition to its potential as a drug target, MMP17 also has several potential uses as a biomarker. Its unique structure and various bioactive peptides have make it an attractive target for the development of diagnostic tools and cancer biomarkers. Several studies have shown that MMP17 can be used as a reliable biomarker for various types of cancer, including breast, ovarian, and colorectal cancers. In addition, its ability to be inhibited using small molecules and its role in cell signaling have also made it an attractive target for the development of anti-cancer drugs.

In conclusion, MMP17 is a protein that is rich in bioactive peptides and has several potential functions as a drug target or biomarker. Its unique structure and various bioactive peptides have make it an attractive target for the development of new cancer therapies, while its role in cell signaling and its potential as a biomarker for cancer diagnosis and treatment further highlight its potential. As research continues to advance in the field of MMP17, it is likely that new insights and findings will emerge that will further define its role and potential as a drug target or biomarker.

Protein Name: Matrix Metallopeptidase 17

Functions: Endopeptidase that degrades various components of the extracellular matrix, such as fibrin. May be involved in the activation of membrane-bound precursors of growth factors or inflammatory mediators, such as tumor necrosis factor-alpha. May also be involved in tumoral process. Cleaves pro-TNF-alpha at the '74-Ala-|-Gln-75' site. Not obvious if able to proteolytically activate progelatinase A. Does not hydrolyze collagen types I, II, III, IV and V, gelatin, fibronectin, laminin, decorin nor alpha1-antitrypsin

The "MMP17 Target / Biomarker Review Report" is a customizable review of hundreds up to thousends of related scientific research literature by AI technology, covering specific information about MMP17 comprehensively, including but not limited to:
•   general information;
•   protein structure and compound binding;
•   protein biological mechanisms;
•   its importance;
•   the target screening and validation;
•   expression level;
•   disease relevance;
•   drug resistance;
•   related combination drugs;
•   pharmacochemistry experiments;
•   related patent analysis;
•   advantages and risks of development, etc.
The report is helpful for project application, drug molecule design, research progress updates, publication of research papers, patent applications, etc. If you are interested to get a full version of this report, please feel free to contact us at BD@silexon.ai

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