NWD1: A Promising Target for Drug Development and Biomarker (G284434)

Target Name: NWD1

NCBI ID: G284434

NWD1

Other Name(s): NACHT domain- and WD repeat-containing protein 1 (isoform 2) | NWD1 variant 1 | NACHT and WD repeat domain-containing protein 1 | NACHT and WD repeat domain containing 1, transcript variant 2 | NWD1 variant 2 | NACHT domain- and WD repeat-containing protein 1 (isoform 1) | NACHT and WD repeat domain containing 1, transcript variant 1 | NACHT and WD repeat domain containing 1 | NACHT domain- and WD repeat-containing protein 1 | NWD1_HUMAN

NWD1: A Promising Target for Drug Development and Biomarker

The protein encoded by the gene NACHT domain- and WD repeat-containing protein 1 (ISOform 2) is a member of the nucleotide-binding oligomerization domain (NBO domain) family, which is characterized by the presence of a nucleotide-binding domain and a hydrophobic tail. This protein is highly conserved across various species, including human, and has been implicated in various cellular processes, including DNA replication, transcription, and DNA damage repair.

NWD1 has been shown to play a critical role in the regulation of gene expression and has been involved in the development and progression of various diseases, including cancer. Its involvement in these processes has led to its potential as a drug target or biomarker.

One of the key functions of NWD1 is its ability to interact with specific DNA sequences. This interaction is mediated by the NBO domain, which is known for its ability to form a stable complex with the nucleotide GGACTTTAGGG. This interaction allows the NBO domain to recruit Various DNA-binding proteins, including the transcription factor TF-1, to the target DNA region.

The NBO domain is composed of multiple domains, including an alpha helix, a beta strand, and a loop region. The alpha helix is 鈥嬧?媟esponsible for the formation of a stable complex with DNA, while the beta strand provides structural stability to the complex. loop region is involved in the formation of the NBO domain-DNA complex and is thought to play a structural role in the interaction between the NBO domain and DNA.

Several studies have demonstrated the importance of the NBO domain in the regulation of gene expression. For example, studies have shown that NBO domains can interact with various DNA sequences and that this interaction can modulate gene expression. Additionally, the NBO domain has been shown to play a role in the regulation of DNA replication, as it has been shown to interact with the protein responsible for the initiation of DNA replication, DnaB.

NWD1 has also been shown to be involved in the regulation of transcription factor activity. Studies have shown that the NBO domain can interact with the DNA-binding protein p16, which is known for its role in the regulation of gene expression. This interaction allows the NBO domain to recruit p16 to the target DNA region and potentially modulate its activity.

In addition to its role in the regulation of gene expression, NWD1 has also been shown to play a critical role in the development and progression of various diseases. For example, studies have shown that high levels of NACHT domain-containing proteins are associated with the development of cancer. Additionally, the NBO domain has been shown to play a role in the regulation of cell cycle progression, as it has been shown to interact with the protein responsible for the maintenance of the cell cycle, p21.

Given the involvement of NWD1 in various cellular processes, it is a promising target for drug development. Studies have shown that inhibitors of the NBO domain can be effective in treating various diseases, including cancer. domain can be effective in inhibiting the growth of cancer cells and may be a potential treatment for cancer.

In addition to its potential as a drug target, NWD1 has also been shown to be a potential biomarker for various diseases. The NBO domain is conserved across various species and has been shown to play a role in the regulation of gene expression, which makes it a potential biomarker for diseases that are characterized by disruptions in gene expression.

Overall, the protein encoded by the gene NACHT domain- and WD repeat-containing protein 1 (ISOform 2) is a promising target for drug development due to its involvement in various cellular processes and its potential as a biomarker. Further research is needed to fully understand the role of this protein in disease progression and its potential as a drug or biomarker.

Protein Name: NACHT And WD Repeat Domain Containing 1

Functions: May play a role in the control of androgen receptor (AR) protein steady-state levels

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•   the target screening and validation;
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