ZNHIT1: Key Regulator of Neural Development and Plasticity (G10467)

Target Name: ZNHIT1

NCBI ID: G10467

ZNHIT1

ZNHIT1: Key Regulator of Neural Development and Plasticity

Zinc Finger HIT-Type Containing 1 (ZNHIT1) is a protein that is expressed in various tissues throughout the body, including the brain, heart, liver, and muscle. It is a type of zinc finger gene that is characterized by the presence of a zinc finger protein that contains a zinc atom and a short hydrophobic tail. ZNHIT1 is also known as hIT-ZNF2, and it is a key regulator of the neural development and plasticity.

The neural development and plasticity are critical processes that are responsible for the formation and maintenance of neural networks throughout the lifespan. These processes are highly regulated by a large number of proteins, including zinc finger genes. ZNHIT1 is one of the zinc finger genes that is involved in the regulation of neural development and plasticity.

ZNHIT1 is expressed in many different tissues throughout the body, including the brain, heart, liver, and muscle. It is highly expressed in the brain, where it is a critical regulator of neuronal differentiation and synaptic plasticity. ZNHIT1 is also expressed in other tissues, including the heart, liver, and muscle, where it plays a role in the regulation of immune responses, inflammation, and metabolism.

One of the key functions of ZNHIT1 is its role in the regulation of neuronal differentiation and synaptic plasticity. Neurons are highly specialized cells that are responsible for transmitting information throughout the nervous system. Differentiation of neurons into specific types is critical for the development and function of the nervous system, and ZNHIT1 plays a key role in this process.

ZNHIT1 is a critical regulator of neuronal differentiation and synaptic plasticity by controlling the activity of several transcription factors, including NF-kappa-B, AP-1, and STAT3. These transcription factors are responsible for regulating the expression of genes that are involved in the development and maintenance of neural networks. ZNHIT1 helps to ensure that these transcription factors are activated or repressed at the appropriate time, which is essential for the formation and maintenance of neural networks.

In addition to its role in the regulation of neuronal differentiation and synaptic plasticity, ZNHIT1 is also involved in the regulation of several other processes that are important for the maintenance of neural networks. For example, ZNHIT1 is involved in the regulation of cell apoptosis, which is a critical process that helps to remove damaged or dysfunctional neurons from the nervous system. It is also involved in the regulation of inflammation, which is important for the immune response to infection and damage.

Given its role in the regulation of neural development and plasticity, ZNHIT1 is a potential drug target for several diseases. For example, ZNHIT1 has been shown to be involved in the development of several neurological disorders, including Alzheimer's disease, Parkinson's disease, and Huntington's disease. It is also involved in the regulation of the immune response, which is a potential target for several autoimmune diseases.

In conclusion, ZNHIT1 is a protein that is expressed in various tissues throughout the body and plays a critical role in the regulation of neural development and plasticity. It is a potential drug target for several diseases and is an important target for researchers studying the mechanisms of neural development and plasticity. Further research is needed to fully understand the functions of ZNHIT1 and its potential as a drug target.

Protein Name: Zinc Finger HIT-type Containing 1

Functions: Plays a role in chromatin remodeling by promoting the incorporation of histone variant H2AZ1/H2A.Z into the genome to regulate gene expression (PubMed:20473270, PubMed:35175558). Promotes SRCAP complex-mediated deposition of histone variant H2AZ1 to lymphoid fate regulator genes, enhancing lymphoid lineage commitment (By similarity). Recruited to the promoter of the transcriptional activator MYOG at the early stages of muscle differentiation where it mediates binding of histone H2AZ1 to chromatin and induces muscle-specific gene expression (PubMed:20473270). Maintains hematopoietic stem cell (HSC) quiescence by determining the chromatin accessibility at distal enhancers of HSC quiescence genes such as PTEN, FSTL1 and KLF4, enhancing deposition of H2AZ1 to promote their sustained transcription and restricting PI3K-AKT signaling inhibition (By similarity). Plays a role in intestinal stem cell maintenance by promoting H2AZ1 deposition at the transcription start sites of genes involved in intestinal stem cell fate determination including LGR5, TGFB1 and TGFBR2, thereby contributing to gene transcription (By similarity). Promotes phosphorylation of the H2AZ1 chaperone VPS72/YL1 which enhances the interaction between HZAZ1 and VPS72 (By similarity). Regulates the entry of male germ cells into meiosis by controlling histone H2AZ1 deposition which facilitates the expression of meiotic genes such as MEIOSIN, leading to the initiation of meiosis (By similarity). Required for postnatal heart function through its role in maintenance of cardiac Ca(2+) homeostasis by modulating the expression of Ca(2+)-regulating proteins CASQ1 and ATP2A2/SERCA2A via deposition of histone H2AZ1 at their promoters (By similarity). During embryonic heart development, required for mitochondrial maturation and oxidative metabolism by functioning through H2AZ1 deposition to activate transcription of metabolic genes and is also required to maintain the stability of the respiratory complex (By similarity). In neural cells, increases deposition of the H2AZ1 histone variant and promotes neurite growth (PubMed:35175558). Plays a role in TP53/p53-mediated apoptosis induction by stimulating the transcriptional activation of several proapoptotic p53 target genes such as PMAIP1/NOXA and BBC3/PUMA (PubMed:17380123). Mediates cell cycle arrest induced in response to gamma-irradiation by enhancing recruitment of TP53/p53 to the promoter of the cell cycle inhibitor CDKN1A, leading to its transcriptional activation (PubMed:17700068). Recruited to the promoter of cyclin-dependent kinase CDK6 and inhibits its transcription, possibly by decreasing the acetylation level of histone H4, leading to cell cycle arrest at the G1 phase (By similarity). Plays a role in lens fiber cell differentiation by regulating the expression of cell cycle regulator CDKN1A/p21Cip1 (By similarity). Binds to transcriptional repressor NR1D2 and relieves it of its inhibitory effect on the transcription of apolipoprotein APOC3 without affecting its DNA-binding activity (PubMed:17892483)

The "ZNHIT1 Target / Biomarker Review Report" is a customizable review of hundreds up to thousends of related scientific research literature by AI technology, covering specific information about ZNHIT1 comprehensively, including but not limited to:
•   general information;
•   protein structure and compound binding;
•   protein biological mechanisms;
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•   the target screening and validation;
•   expression level;
•   disease relevance;
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•   pharmacochemistry experiments;
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•   advantages and risks of development, etc.
The report is helpful for project application, drug molecule design, research progress updates, publication of research papers, patent applications, etc. If you are interested to get a full version of this report, please feel free to contact us at BD@silexon.ai

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