Target Name: GUCA2A
NCBI ID: G2980
Review Report on GUCA2A Target / Biomarker Content of Review Report on GUCA2A Target / Biomarker
GUCA2A
Other Name(s): guanylate cyclase activator 2A (guanylin 2, intestinal, heat-stable) | Guanylin | HMW-guanylin | prepro-guanylin | guanylate cyclase-activating protein 1 | STARA | GUCA2 | GUC2A_HUMAN | Guanylate cyclase-activating protein I | Guanylate cyclase activator 2A (guanylin 2, intestinal, heat-stable) | Guanylate cyclase activator 2A | Guanylate cyclase-activating protein 1 | guanylate cyclase-activating protein I | guanylate cyclase activator 2A | GCAP-I

Understanding GUCA2A: A Key Enzyme in Cellular Signaling

GUCA2A, also known as guanylate cyclase activator 2A, is a protein that is expressed in various tissues throughout the body. It is a key enzyme in the intracellular signaling pathway known as the G-protein-coupled receptor (GPCR) signaling pathway. This pathway is involved in a wide range of physiological processes in the body, including sensory perception, neurotransmission, and hormone regulation.

GUCA2A is a 21-kDa protein that is expressed in the heart, liver, pancreas, and other tissues. It is primarily localized to the endoplasmic reticulum (ER), where it is involved in the intracellular delivery of various signaling molecules, including hormones and neurotransmitters. GUCA2A is also involved in the regulation of cellular signaling pathways, including the production of reactive oxygen species (ROS) and the detoxification of xenobiotics.

One of the unique features of GUCA2A is its role in the regulation of ion channels, which are responsible for the rapid and selective transmembrane flow of ions and other molecules into and out of cells. The ability of GUCA2A to regulate these channels allows it to play a critical role in the regulation of various physiological processes, including muscle contractions, nerve impulses, and the regulation of blood pressure.

Another important function of GUCA2A is its role in the regulation of cellular signaling pathways that are involved in cell growth, apoptosis, and apoptosis. GUCA2A is involved in the production of ROS, which are reactive oxygen species that can damage cellular components and contribute to the development of various diseases, including cancer. Additionally, GUCA2A is involved in the regulation of the production of pro-inflammatory cytokines, which can contribute to the development of inflammation and other diseases.

GUCA2A is also involved in the regulation of cellular signaling pathways that are involved in hormone regulation, neurotransmission, and other physiological processes. For example, GUCA2A is involved in the regulation of the production of sex hormones, including estrogen and testosterone. in the regulation of neurotransmitters, such as dopamine and serotonin, which are involved in the transmission of signals between neurons and other cells.

GUCA2A is a potential drug target for a variety of diseases, including cancer, neurodegenerative diseases, and cardiovascular diseases. For example, GUCA2A has been shown to be involved in the regulation of the production of ROS, which can contribute to the development of various diseases. . Additionally, GUCA2A is involved in the regulation of cellular signaling pathways that are involved in inflammation and other diseases, which may contribute to its involvement in the development of certain inflammatory disorders.

In conclusion, GUCA2A is a protein that is involved in a wide range of physiological processes in the body. Its role in the regulation of cellular signaling pathways, including those involved in ion channels, hormone regulation, and neurotransmission, makes it a potential drug target for a variety of diseases. Further research is needed to fully understand the functions of GUCA2A and its potential as a drug target.

Protein Name: Guanylate Cyclase Activator 2A

Functions: Endogenous activator of intestinal guanylate cyclase. It stimulates this enzyme through the same receptor binding region as the heat-stable enterotoxins

The "GUCA2A Target / Biomarker Review Report" is a customizable review of hundreds up to thousends of related scientific research literature by AI technology, covering specific information about GUCA2A comprehensively, including but not limited to:
•   general information;
•   protein structure and compound binding;
•   protein biological mechanisms;
•   its importance;
•   the target screening and validation;
•   expression level;
•   disease relevance;
•   drug resistance;
•   related combination drugs;
•   pharmacochemistry experiments;
•   related patent analysis;
•   advantages and risks of development, etc.
The report is helpful for project application, drug molecule design, research progress updates, publication of research papers, patent applications, etc. If you are interested to get a full version of this report, please feel free to contact us at BD@silexon.ai

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GUCA2B | GUCD1 | GUCY1A1 | GUCY1A2 | GUCY1B1 | GUCY1B2 | GUCY2C | GUCY2D | GUCY2EP | GUCY2F | GUCY2GP | GUF1 | GUK1 | GULOP | GULP1 | GUSB | GUSBP1 | GUSBP11 | GUSBP12 | GUSBP14 | GUSBP15 | GUSBP17 | GUSBP2 | GUSBP3 | GUSBP4 | GUSBP5 | GUSBP8 | GVINP1 | GVQW3 | GXYLT1 | GXYLT1P3 | GXYLT1P4 | GXYLT1P6 | GXYLT2 | GYG1 | GYG2 | GYPA | GYPB | GYPC | GYPE | GYS1 | GYS2 | GZF1 | GZMA | GZMB | GZMH | GZMK | GZMM | H1-0 | H1-1 | H1-10 | H1-10-AS1 | H1-2 | H1-3 | H1-4 | H1-5 | H1-6 | H1-7 | H1-8 | H1-9P | H19 | H19-ICR | H2AB1 | H2AB2 | H2AB3 | H2AC1 | H2AC11 | H2AC12 | H2AC13 | H2AC14 | H2AC15 | H2AC16 | H2AC17 | H2AC18 | H2AC20 | H2AC21 | H2AC25 | H2AC3P | H2AC4 | H2AC6 | H2AC7 | H2AJ | H2AP | H2AX | H2AZ1 | H2AZ1-DT | H2AZ2 | H2AZ2-DT | H2AZP2 | H2BC1 | H2BC10 | H2BC11 | H2BC12 | H2BC12L | H2BC13 | H2BC14 | H2BC15 | H2BC17 | H2BC18 | H2BC20P