H2AB3: A Potential Drug Target for Cancer and Other Diseases (G83740)
H2AB3: A Potential Drug Target for Cancer and Other Diseases
Histone variants, such as H2AB3 (histone variant H2A, barr-body deficient), have been identified as potential drug targets or biomarkers in various diseases. H2AB3 is a histone variant that is found in humans, and it has been shown to play a role in the development and progression of various diseases, including cancer.
The histone is a protein that is found in the nucleus of every cell in the body. It plays a critical role in the regulation of gene expression, and it is known for its ability to alter the state of the cell, either in a beneficial or harmful way. Histone variants, such as H2AB3, can alter the way that histones behave and can lead to the development of diseases.
One of the key features of H2AB3 is its ability to interact with other proteins, including the protein known as MBD2. MBD2 is a protein that is found in many tissues throughout the body, including the brain, and it is known for its role in the development of cancer.
Research has shown that H2AB3 can interact with MBD2 and that this interaction may play a role in the development of cancer. Studies have shown that when H2AB3 is present in cells, it can interact with MBD2 and cause the latter to accumulate in the cells. This increase in MBD2 levels can lead to the formation of tumors, and it is a risk factor for the development of cancer.
Another potential mechanism by which H2AB3 may contribute to the development of cancer is its ability to alter the expression of genes. Histones have the ability to bind to specific genes and regulate the way that these genes are expressed. H2AB3 has been shown to interact with the gene known as APC/CML2, and this interaction may alter the way that this gene is expressed.
Research has shown that when H2AB3 is present in cells, it can interact with APC/CML2 and cause the latter to accumulate in the cells. This increase in APC/CML2 levels can lead to the formation of leukemia, and it is a risk factor for the development of this disease.
In addition to its potential role in the development of cancer, H2AB3 has also been shown to play a role in the development of other diseases. For example, it has been linked to the development of neurodegenerative diseases, such as Alzheimer's and Parkinson's disease.
The identification of H2AB3 as a potential drug target or biomarker has led to a great deal of interest and research in this area. Further studies are needed to fully understand the role of H2AB3 in the development and progression of disease.
Protein Name: H2A.B Variant Histone 3
Functions: Atypical histone H2A which can replace conventional H2A in some nucleosomes and is associated with active transcription and mRNA processing. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. Nucleosomes containing this histone are less rigid and organize less DNA than canonical nucleosomes in vivo. They are enriched in actively transcribed genes and associate with the elongating form of RNA polymerase. They associate with spliceosome components and are required for mRNA splicing. May participate in spermatogenesis
The "H2AB3 Target / Biomarker Review Report" is a customizable review of hundreds up to thousends of related scientific research literature by AI technology, covering specific information about H2AB3 comprehensively, including but not limited to:
• general information;
• protein structure and compound binding;
• protein biological mechanisms;
• its importance;
• the target screening and validation;
• expression level;
• disease relevance;
• drug resistance;
• related combination drugs;
• pharmacochemistry experiments;
• related patent analysis;
• advantages and risks of development, etc.
The report is helpful for project application, drug molecule design, research progress updates, publication of research papers, patent applications, etc. If you are interested to get a full version of this report, please feel free to contact us at BD@silexon.ai
More Common Targets
H2AC1 | H2AC11 | H2AC12 | H2AC13 | H2AC14 | H2AC15 | H2AC16 | H2AC17 | H2AC18 | H2AC20 | H2AC21 | H2AC25 | H2AC3P | H2AC4 | H2AC6 | H2AC7 | H2AJ | H2AP | H2AX | H2AZ1 | H2AZ1-DT | H2AZ2 | H2AZ2-DT | H2AZP2 | H2BC1 | H2BC10 | H2BC11 | H2BC12 | H2BC12L | H2BC13 | H2BC14 | H2BC15 | H2BC17 | H2BC18 | H2BC20P | H2BC21 | H2BC26 | H2BC27P | H2BC3 | H2BC4 | H2BC5 | H2BC6 | H2BC7 | H2BC8 | H2BC9 | H2BP1 | H2BP2 | H2BP3 | H2BW1 | H2BW2 | H2BW4P | H3-3A | H3-3B | H3-4 | H3-5 | H3-7 | H3C1 | H3C10 | H3C11 | H3C12 | H3C13 | H3C14 | H3C15 | H3C2 | H3C3 | H3C4 | H3C6 | H3C7 | H3C8 | H3P16 | H3P36 | H3P37 | H3P44 | H3P5 | H3P6 | H4C1 | H4C11 | H4C12 | H4C13 | H4C14 | H4C15 | H4C16 | H4C2 | H4C3 | H4C4 | H4C5 | H4C6 | H4C7 | H4C8 | H4C9 | H6PD | HAAO | HABP2 | HABP4 | HACD1 | HACD2 | HACD3 | HACD4 | HACE1 | HACL1
