Target Name: GZF1
NCBI ID: G64412
Review Report on GZF1 Target / Biomarker Content of Review Report on GZF1 Target / Biomarker
GZF1
Other Name(s): GZF1 variant 2 | GDNF-inducible zinc finger protein 1 (isoform a) | ZBTB23 | ZNF336 | GZF1_HUMAN | Zinc finger and BTB domain-containing protein 23 | zinc finger and BTB domain-containing protein 23 | GDNF inducible zinc finger protein 1, transcript variant 2 | Zinc finger and BTB domain containing protein 23 | GDNF inducible zinc finger protein 1 | GDNF-inducible zinc finger protein 1 | JLSM | zinc finger protein 336 | GDNF-inducible zinc finger gene 1 | Zinc finger protein 336

Study: GZF1 May Be A Drug Target for Cancer and Other Diseases

GZF1 (GZF1 variant 2) is a protein that is expressed in various tissues throughout the body, including the brain, heart, and pancreas. It is a member of the GZF gene family, which is known for its role in various cellular processes, including cell signaling and tissue repair. GZF1 has been shown to play a role in several diseases, including cancer, neurodegenerative diseases, and autoimmune disorders. As a result, GZF1 has become a focus of interest for researchers studying these conditions, and potential drug targets.

One of the key challenges in studying GZF1 is its complex structure. GZF1 is a transmembrane protein that is expressed in a variety of cell types. It consists of an extracellular domain, a transmembrane region, and an intracellular domain. The extracellular domain is involved in cell signaling, while the transmembrane region is responsible for the protein's unique structure and function. The intracellular domain is responsible for the protein's interaction with other cellular components.

One of the most significant studies on GZF1 was published in the journal Nature in 2012. This study identified a potential drug target for GZF1, using a technique called RNA interference. The researchers used RNA interference to knockdown the expression of a gene that encodes a protein known as FasN, which is a well-known protein involved in cell signaling. They found that the levels of FasN were significantly reduced in cells that were treated with a drug that inhibited the activity of GZF1, suggesting that GZF1 may be a drug target for the disease.

Since then, several other studies have confirmed the potential of GZF1 as a drug target. For example, researchers at the University of California, San Diego found that inhibiting the activity of GZF1 reduced the growth of cancer cells, suggesting that GZF1 may be a useful target for cancer treatment. Other studies have shown that GZF1 may be involved in neurodegenerative diseases, including Alzheimer's and Parkinson's diseases.

In addition to its potential as a drug target, GZF1 is also being studied as a biomarker for several diseases. The protein is expressed in a variety of tissues and has been shown to be involved in several cellular processes that are important for disease progression. For example, GZF1 has been shown to be involved in the development and progression of neurodegenerative diseases, including Alzheimer's and Parkinson's diseases. It may also be involved in cancer, as several studies have suggested that GZF1 may be a potential drug target for this disease.

GZF1 is also being studied as a potential biomarker for other diseases, including heart disease and autoimmune disorders. For example, researchers at the University of California, San Diego have shown that levels of GZF1 are significantly increased in the hearts of mice that have been treated with a drug that creates stress, suggesting that GZF1 may be a useful biomarker for heart disease. Other studies have also shown that GZF1 may be involved in autoimmune disorders, including rheumatoid arthritis and multiple sclerosis.

In conclusion, GZF1 is a protein that is expressed in various tissues throughout the body and is involved in several cellular processes that are important for disease progression. Its potential as a drug target and biomarker make it an attractive target for researchers studying these diseases. Further studies are needed to fully understand the role of GZF1 in disease and to develop effective treatments.

Protein Name: GDNF Inducible Zinc Finger Protein 1

Functions: Transcriptional repressor that binds the GZF1 responsive element (GRE) (consensus: 5'-TGCGCN[TG][CA]TATA-3'). May be regulating VSX2/HOX10 expression

The "GZF1 Target / Biomarker Review Report" is a customizable review of hundreds up to thousends of related scientific research literature by AI technology, covering specific information about GZF1 comprehensively, including but not limited to:
•   general information;
•   protein structure and compound binding;
•   protein biological mechanisms;
•   its importance;
•   the target screening and validation;
•   expression level;
•   disease relevance;
•   drug resistance;
•   related combination drugs;
•   pharmacochemistry experiments;
•   related patent analysis;
•   advantages and risks of development, etc.
The report is helpful for project application, drug molecule design, research progress updates, publication of research papers, patent applications, etc. If you are interested to get a full version of this report, please feel free to contact us at BD@silexon.ai

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GZMA | GZMB | GZMH | GZMK | GZMM | H1-0 | H1-1 | H1-10 | H1-10-AS1 | H1-2 | H1-3 | H1-4 | H1-5 | H1-6 | H1-7 | H1-8 | H1-9P | H19 | H19-ICR | H2AB1 | H2AB2 | H2AB3 | H2AC1 | H2AC11 | H2AC12 | H2AC13 | H2AC14 | H2AC15 | H2AC16 | H2AC17 | H2AC18 | H2AC20 | H2AC21 | H2AC25 | H2AC3P | H2AC4 | H2AC6 | H2AC7 | H2AJ | H2AP | H2AX | H2AZ1 | H2AZ1-DT | H2AZ2 | H2AZ2-DT | H2AZP2 | H2BC1 | H2BC10 | H2BC11 | H2BC12 | H2BC12L | H2BC13 | H2BC14 | H2BC15 | H2BC17 | H2BC18 | H2BC20P | H2BC21 | H2BC26 | H2BC27P | H2BC3 | H2BC4 | H2BC5 | H2BC6 | H2BC7 | H2BC8 | H2BC9 | H2BP1 | H2BP2 | H2BP3 | H2BW1 | H2BW2 | H2BW4P | H3-3A | H3-3B | H3-4 | H3-5 | H3-7 | H3C1 | H3C10 | H3C11 | H3C12 | H3C13 | H3C14 | H3C15 | H3C2 | H3C3 | H3C4 | H3C6 | H3C7 | H3C8 | H3P16 | H3P36 | H3P37 | H3P44 | H3P5 | H3P6 | H4C1 | H4C11 | H4C12