GUK1: A Protein Involved in Cell Survival and Angiogenesis (G2987)
GUK1: A Protein Involved in Cell Survival and Angiogenesis
GUK1 (Guanylate kinase) is a protein that is expressed in various tissues throughout the body. It is a key enzyme in the intracellular signaling pathway known as the PI3K/Akt pathway, which is involved in a wide range of cellular processes, including cell survival, proliferation, and angiogenesis. GUK1 has also been implicated in the development and progression of various diseases, including cancer, neurodegenerative diseases, and autoimmune disorders. As a result, GUK1 has become a focus of interest for researchers as a potential drug target or biomarker.
The PI3K/Akt pathway is a complex signaling pathway that is involved in the regulation of cellular processes such as cell survival, angiogenesis, and inflammation. The pathway is composed of several key components, including GUK1, which is a protein that is critical for the activation and maintenance of the pathway. GUK1 is a kinase, which means that it adds a phosphate group to other proteins, allowing them to interact with one another and facilitate the signaling process.
GUK1 is involved in the regulation of several cellular processes that are critical for the survival and proliferation of cells. For example, GUK1 has been shown to play a role in the regulation of cell survival and apoptosis. Studies have shown that GUK1 can induce cell apoptosis in various cellular models, including cancer cells and neurodegenerative cells. In addition, GUK1 has been shown to promote the survival of cancer cells, which may contribute to the development and progression of cancer.
GUK1 has also been implicated in the regulation of cellular proliferation. Studies have shown that GUK1 can inhibit the inhibition of cell proliferation, which may contribute to the development of cancer. In addition, GUK1 has been shown to promote the growth and survival of various types of cancer cells, which may contribute to their development and progression.
In addition to its role in cellular survival and proliferation, GUK1 has also been implicated in the regulation of cellular angiogenesis. Angiogenesis is the process by which new blood vessels are formed in the body, and it is critical for the delivery of oxygen and nutrients to tissues. GUK1 has been shown to play a role in the regulation of angiogenesis, including the formation of blood vessels in the brain and the regulation of blood vessel diameter.
GUK1 has also been implicated in the development and progression of various diseases, including cancer, neurodegenerative diseases, and autoimmune disorders. For example, studies have shown that GUK1 is involved in the development of neurodegenerative diseases, including Alzheimer's disease and Parkinson's disease. In addition, GUK1 has been shown to be involved in the regulation of the immune system, which may contribute to the development and progression of autoimmune disorders.
Despite these promising findings, the role of GUK1 in the PI3K/Akt pathway and its potential as a drug target or biomarker is still an area of ongoing research. Many researchers are interested in the potential therapeutic benefits of targeting GUK1, either alone or in combination with other treatments, for the treatment of various diseases. As the understanding of the role of GUK1 in cellular processes and its potential as a drug target or biomarker continues to evolve, it is likely that new treatments and therapies will be discovered that can improve the health and well-being of individuals.
Protein Name: Guanylate Kinase 1
Functions: Catalyzes the phosphorylation of GMP to GDP. Essential enzyme for recycling GMP and indirectly, cyclic GMP (cGMP) (PubMed:31201273). Involved in the cGMP metabolism in photoreceptors (By similarity). It may also have a role in the survival and growth progression of some tumors (PubMed:31201273). In addition to its physiological role, GUK1 is essential for convert prodrugs used for the treatment of cancers and viral infections into their pharmacologically active metabolites, most notably acyclovir, ganciclovir, and 6-thioguanine and its closely related analog 6-mercaptopurine (PubMed:197968, PubMed:6248551, PubMed:6306664)
The "GUK1 Target / Biomarker Review Report" is a customizable review of hundreds up to thousends of related scientific research literature by AI technology, covering specific information about GUK1 comprehensively, including but not limited to:
• general information;
• protein structure and compound binding;
• protein biological mechanisms;
• its importance;
• the target screening and validation;
• expression level;
• disease relevance;
• drug resistance;
• related combination drugs;
• pharmacochemistry experiments;
• related patent analysis;
• advantages and risks of development, etc.
The report is helpful for project application, drug molecule design, research progress updates, publication of research papers, patent applications, etc. If you are interested to get a full version of this report, please feel free to contact us at BD@silexon.ai
More Common Targets
GULOP | GULP1 | GUSB | GUSBP1 | GUSBP11 | GUSBP12 | GUSBP14 | GUSBP15 | GUSBP17 | GUSBP2 | GUSBP3 | GUSBP4 | GUSBP5 | GUSBP8 | GVINP1 | GVQW3 | GXYLT1 | GXYLT1P3 | GXYLT1P4 | GXYLT1P6 | GXYLT2 | GYG1 | GYG2 | GYPA | GYPB | GYPC | GYPE | GYS1 | GYS2 | GZF1 | GZMA | GZMB | GZMH | GZMK | GZMM | H1-0 | H1-1 | H1-10 | H1-10-AS1 | H1-2 | H1-3 | H1-4 | H1-5 | H1-6 | H1-7 | H1-8 | H1-9P | H19 | H19-ICR | H2AB1 | H2AB2 | H2AB3 | H2AC1 | H2AC11 | H2AC12 | H2AC13 | H2AC14 | H2AC15 | H2AC16 | H2AC17 | H2AC18 | H2AC20 | H2AC21 | H2AC25 | H2AC3P | H2AC4 | H2AC6 | H2AC7 | H2AJ | H2AP | H2AX | H2AZ1 | H2AZ1-DT | H2AZ2 | H2AZ2-DT | H2AZP2 | H2BC1 | H2BC10 | H2BC11 | H2BC12 | H2BC12L | H2BC13 | H2BC14 | H2BC15 | H2BC17 | H2BC18 | H2BC20P | H2BC21 | H2BC26 | H2BC27P | H2BC3 | H2BC4 | H2BC5 | H2BC6 | H2BC7 | H2BC8 | H2BC9 | H2BP1 | H2BP2 | H2BP3
