H2AC21: A Protein Regulator of Cancer Development (G317772)

H2AC21: A Protein Regulator of Cancer Development

H2AC21, also known as H2A2B_HUMAN, is a protein that is expressed in various tissues of the human body, including the brain, heart, liver, and muscle. It is a key regulator of the hydrogen balance in the body and plays a crucial role in the development and progression of various diseases, including cancer.

H2AC21 is a transmembrane protein that is composed of two main domains: an N-terminal transmembrane domain and a C-terminal extracellular domain. The N-terminal domain is responsible for the protein's ability to interact with various cell signaling pathways, including the TGF-β pathway. The C-terminal domain is involved in the protein's stability and functions as a scaffold to recruit other proteins to the plasma membrane.

H2AC21 has been shown to play a key role in the regulation of cellular processes that are critical for the development and progression of cancer. One of the primary functions of H2AC21 is its ability to inhibit the signaling pathway known as the TGF-β pathway. The TGF-β pathway is a well-established mechanism that promotes cell growth, division, and angiogenesis, and is often associated with the development of various diseases, including cancer.

H2AC21 has been shown to play a negative role in the TGF-β pathway by inhibiting the activity of the transcription factor SMAD1. SMAD1 is a key player in the TGF-β pathway and is often activated in response to TGF-β signaling. H2AC21 has been shown to prevent SMAD1 from activating and to downregulate its activity, thereby inhibiting the TGF-β pathway.

H2AC21 has also been shown to play a role in the regulation of cellular apoptosis, which is the process by which cells undergo programmed cell death.Apoptosis is a natural process that helps to remove damaged or dysfunctional cells from the body, and is important for the development and progression of diseases. H2AC21 has been shown to regulate apoptosis by activating the Bcl-2 protein, which is a protein that can prevent apoptosis.

Another function of H2AC21 is its ability to regulate the cytoskeleton, which is the structure that gives cells shape and stability. The cytoskeleton is responsible for the maintenance of cell shape, as well as the regulation of cell movement and the development of cell processes such as mitosis. H2AC21 has been shown to play a role in the regulation of cytoskeleton by regulating the activity of the protein tyrosine kinase, which is involved in the regulation of cytoskeleton structure and dynamics.

In addition to its role in the regulation of cellular processes, H2AC21 has also been shown to play a role in the development and progression of cancer. Studies have shown that H2AC21 is often overexpressed in various tissues of cancer and that its levels are correlated with the severity of cancer. Additionally, H2AC21 has been shown to promote the growth and survival of cancer cells in cell culture and animal models.

Furthermore, H2AC21 has also been shown to play a role in the regulation of inflammation, which is a complex and critical process that helps to maintain the immune system and protect the body against infection. The regulation of inflammation is critical for the development and progression of many diseases, including cancer. H2AC21 has been shown to play a role in the regulation of inflammation by regulating the activity of immune cells and by promoting the production of pro-inflammatory cytokines.

In conclusion, H2AC21 is a protein that plays a critical role in the regulation of various cellular processes that are critical for the development and progression of cancer. Its ability to inhibit the TGF-β pathway and to regulate apoptosis, cytoskeleton and inflammation makes it an attractive drug target and a potential biomarker for cancer diagnosis and treatment. Further studies are needed to fully understand the role of H2AC21 in the development and progression of cancer and to determine its potential as a drug.

Protein Name: H2A Clustered Histone 21

Functions: Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling

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More Common Targets

H2AC25 | H2AC3P | H2AC4 | H2AC6 | H2AC7 | H2AJ | H2AP | H2AX | H2AZ1 | H2AZ1-DT | H2AZ2 | H2AZ2-DT | H2AZP2 | H2BC1 | H2BC10 | H2BC11 | H2BC12 | H2BC12L | H2BC13 | H2BC14 | H2BC15 | H2BC17 | H2BC18 | H2BC20P | H2BC21 | H2BC26 | H2BC27P | H2BC3 | H2BC4 | H2BC5 | H2BC6 | H2BC7 | H2BC8 | H2BC9 | H2BP1 | H2BP2 | H2BP3 | H2BW1 | H2BW2 | H2BW4P | H3-3A | H3-3B | H3-4 | H3-5 | H3-7 | H3C1 | H3C10 | H3C11 | H3C12 | H3C13 | H3C14 | H3C15 | H3C2 | H3C3 | H3C4 | H3C6 | H3C7 | H3C8 | H3P16 | H3P36 | H3P37 | H3P44 | H3P5 | H3P6 | H4C1 | H4C11 | H4C12 | H4C13 | H4C14 | H4C15 | H4C16 | H4C2 | H4C3 | H4C4 | H4C5 | H4C6 | H4C7 | H4C8 | H4C9 | H6PD | HAAO | HABP2 | HABP4 | HACD1 | HACD2 | HACD3 | HACD4 | HACE1 | HACL1 | HADH | HADHA | HADHAP1 | HADHB | HAFML | HAGH | HAGHL | HAGLR | HAGLROS | HAL | HAMP