H2AC12: A Protein Involved in Cellular Processes and Potential Drug Targets
H2AC12: A Protein Involved in Cellular Processes and Potential Drug Targets
H2AC12 (dJ86C11.1) is a protein that is expressed in various tissues of the body, including the brain, heart, and kidneys. It is a member of the H2A subfamily of the histone gene family and is involved in the regulation of gene expression and DNA replication.
H2AC12 has been identified as a potential drug target in several diseases, including cancer, neurodegenerative diseases, and autoimmune disorders. Its role in these conditions is not well understood, but it is thought to play a negative role in the development and progression of these diseases.
One of the key functions of H2AC12 is its role in the regulation of microRNA (miRNA) levels. MiRNA are small non-coding RNAs that play a critical role in post-transcriptional gene regulation by binding to specific target genes and regulating their translation into protein. H2AC12 has been shown to interact with miRNA-21, a known regulator ofmiRNA levels, and to play a role in the negative regulation of miRNA levels.
In addition to its role in miRNA regulation, H2AC12 is also involved in the regulation of DNA replication. During DNA replication, H2AC12 is thought to play a role in the recruitment of the enzyme DNA polymerase II (DPI) to the replication complex, where it may contribute to the proper assembly and function of the replication machinery.
H2AC12 is also involved in the regulation of cell adhesion and migration. Its expression has been shown to be regulated by factors such as Wnt, a signaling molecule that plays a role in the development and maintenance of tissues and organs, and TGF-β, aTransforming growth factor that is involved in cell signaling and growth.
In conclusion, H2AC12 is a protein that is involved in a number of important cellular processes that are regulated by a variety of factors. Its role in the regulation of miRNA levels, DNA replication, cell adhesion and migration, and other processes makes it an attractive target for further study and potential therapeutic intervention. Further research is needed to fully understand the role of H2AC12 in these processes and to determine its potential as a drug target.
Protein Name: H2A Clustered Histone 12
Functions: Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling
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• general information;
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• expression level;
• disease relevance;
• drug resistance;
• related combination drugs;
• pharmacochemistry experiments;
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• advantages and risks of development, etc.
The report is helpful for project application, drug molecule design, research progress updates, publication of research papers, patent applications, etc. If you are interested to get a full version of this report, please feel free to contact us at BD@silexon.ai
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