H2BC9: A Protein Involved in Gene Expression, DNA Replication and Cellular Processes
H2BC9: A Protein Involved in Gene Expression, DNA Replication and Cellular Processes
Histone cluster 1 (H2A.2, H2B.2, H2C.1, H2C.2) is a protein that plays a critical role in the regulation of gene expression and DNA replication. It is composed of four subunits, H2A, H2B, H2C, and H2D, which are held together by multiple hydrogen bonds. H2BC9 (histone cluster 1) is a 9 kDa protein that is composed of two subunits, H2A8 and H2B7. H2BC9 is a key protein that is involved in the regulation of gene expression, DNA replication, and other cellular processes.
H2BC9 is a member of the histone family, which is a family of proteins that are responsible for the regulation of gene expression. Histones are small, positively charged proteins that are composed of four subunits. They are held together by multiple hydrogen bonds, which gives them their unique structure and stability. Histones have been shown to play a critical role in the regulation of gene expression by modulating the activity of various transcription factors.
H2BC9 is a key protein that is involved in the regulation of gene expression. It is a negative regulator of the Runx1 gene, which is a transcription factor that is involved in the regulation of cellular processes such as cell growth, differentiation, and inflammation. H2BC9 has been shown to interact with Runx1 and prevent it from activating the gene. This interaction between H2BC9 and Runx1 suggests that H2BC9 may be a drug target or biomarker for the treatment ofRunx1-related diseases.
H2BC9 is also involved in the regulation of DNA replication. It is a component of the replication complex II (RC2), which is responsible for the duplication of DNA during the process of cell division. H2BC9 plays a critical role in the regulation of RC2, as it is involved in the formation of the replication complex. This suggests that H2BC9 may be a drug target or biomarker for the treatment of DNA replication-related diseases.
In addition to its role in gene expression and DNA replication, H2BC9 is also involved in the regulation of other cellular processes. It is a member of the microtubule protein family, which is responsible for the regulation of cell movement and the cytoskeleton. H2BC9 plays a critical role in the regulation of microtubule dynamics, as it is involved in the formation and dynamics of microtubules. This suggests that H2BC9 may be a drug target or biomarker for the treatment of microtubule-related diseases.
H2BC9 is also involved in the regulation of cell survival. It is a component of the B-cell lymphoma survival signaling pathway, which is responsible for the survival and proliferation of B-cell lymphocytes. H2BC9 plays a critical role in the regulation of this pathway, as it is involved in the signaling of cell survival. This suggests that H2BC9 may be a drug target or biomarker for the treatment of B-cell lymphoma.
In conclusion, H2BC9 is a 9 kDa protein that is involved in the regulation of gene expression, DNA replication, microtubule dynamics, and cell survival. It is a key protein that is involved in the regulation of various cellular processes and has been shown to play a critical role in the regulation ofRunx1, RC2, microtubule dynamics, and cell survival. Based on these findings, H2BC9 may be a drug target or biomarker for the treatment ofRunx1-related diseases, DNA replication-related diseases, microtubule-related diseases, and B-cell lymphoma. Further research is needed to fully understand the role of H2BC9 in cellular processes and to develop effective treatments for these diseases.
Protein Name: H2B Clustered Histone 9
Functions: Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling
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More Common Targets
H2BP1 | H2BP2 | H2BP3 | H2BW1 | H2BW2 | H2BW4P | H3-3A | H3-3B | H3-4 | H3-5 | H3-7 | H3C1 | H3C10 | H3C11 | H3C12 | H3C13 | H3C14 | H3C15 | H3C2 | H3C3 | H3C4 | H3C6 | H3C7 | H3C8 | H3P16 | H3P36 | H3P37 | H3P44 | H3P5 | H3P6 | H4C1 | H4C11 | H4C12 | H4C13 | H4C14 | H4C15 | H4C16 | H4C2 | H4C3 | H4C4 | H4C5 | H4C6 | H4C7 | H4C8 | H4C9 | H6PD | HAAO | HABP2 | HABP4 | HACD1 | HACD2 | HACD3 | HACD4 | HACE1 | HACL1 | HADH | HADHA | HADHAP1 | HADHB | HAFML | HAGH | HAGHL | HAGLR | HAGLROS | HAL | HAMP | HAND1 | HAND2 | HAND2-AS1 | HAO1 | HAO2 | HAO2-IT1 | HAP1 | HAPLN1 | HAPLN2 | HAPLN3 | HAPLN4 | HAPSTR1 | HAR1A | HAR1B | HARBI1 | HARS1 | HARS2 | HAS1 | HAS2 | HAS2-AS1 | HAS3 | HASPIN | HAT1 | HAUS1 | HAUS1P1 | HAUS2 | HAUS3 | HAUS4 | HAUS5 | HAUS6 | HAUS7 | HAUS8 | HAVCR1 | HAVCR1P1
