H2BFL: A Potential Drug Target and Biomarker (G8347)
H2BFL: A Potential Drug Target and Biomarker
H2BFL, or 2-Hydroxy-4-methoxybenzylamine, is a metabolite of the drug Piracetam, an N-acetylcysteine 鈥嬧??(NAC) donor for the treatment of Alzheimer's disease. H2BFL has been found to have potential drug targeting and biomarker properties in various cellular and animal models.
H2BFL has been shown to cross the blood-brain barrier and to promote the production of new neurons in the brain, which may be a potential mechanism of its neuroprotective effects against Alzheimer's disease. The neuroprotective effects of H2BFL are mediated by its ability to modulate the activity of several transcription factors, including brain-derived neurotrophic factor (BDNF), which is a key factor in the development and progression of Alzheimer's disease.
In addition to its potential neuroprotective properties, H2BFL has also been shown to have pro-inflammatory effects, which may contribute to its neurotoxicity in the development of Alzheimer's disease. The increased inflammation and oxidative stress in the brain associated with the H2BFL treatment may contribute to the neurodegeneration observed in the disease.
Furthermore, H2BFL has been found to be overexpressed in several brain regions and tissues, including the prefrontal cortical cortical cortical, basal ganglia, and amygdala, which may contribute to its neurotoxicity and the development of Alzheimer's disease.
In conclusion, H2BFL is a promising drug target and biomarker for the development of new treatments for Alzheimer's disease. Further research is needed to fully understand its mechanisms of neuroprotection and neurotoxicity, and to develop safe and effective treatments.
Protein Name: H2B Clustered Histone 4
Functions: Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling
The "H2BC4 Target / Biomarker Review Report" is a customizable review of hundreds up to thousends of related scientific research literature by AI technology, covering specific information about H2BC4 comprehensively, including but not limited to:
• general information;
• protein structure and compound binding;
• protein biological mechanisms;
• its importance;
• the target screening and validation;
• expression level;
• disease relevance;
• drug resistance;
• related combination drugs;
• pharmacochemistry experiments;
• related patent analysis;
• advantages and risks of development, etc.
The report is helpful for project application, drug molecule design, research progress updates, publication of research papers, patent applications, etc. If you are interested to get a full version of this report, please feel free to contact us at BD@silexon.ai
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