OPN5: A Potential Drug Target Or Biomarker (G221391)
OPN5: A Potential Drug Target Or Biomarker
OPN5 (OPN5_HUMAN), a protein that belongs to the opsin family, has been identified as a potential drug target or biomarker for the treatment of various diseases, including cancer, neurodegenerative disorders, andurological problems.
OPN5 is a protein that is expressed in most tissues of the body and is involved in the sense of light and vision. It is a member of the opsin family, which includes proteins that are responsible for transmitting information about light intensity and color to the brain.
Research has shown that OPN5 is involved in many different processes in the body, including the sense of smell, the sensation of pain, and the regulation of blood pressure. It is also involved in the development and maintenance of the retina, and has been shown to play a role in the development of age-related macular degeneration (AMD).
As a result of its involvement in these processes, OPN5 has been considered as a potential drug target for a variety of diseases. One of the main reasons for this is that OPN5 is involved in many different signaling pathways, which makes it an attractive target for drugs that can inhibit its activity.
OPN5 can be targeted by small molecules, antibodies, or vaccines. For example, a team of researchers at the University of California, San Diego has developed a small molecule that can inhibit the activity of OPN5 and prevent it from contributing to the development of certain diseases.
Another team of researchers at the University of Pennsylvania has developed an antibody that can target OPN5 and inhibit its activity in the body. This approach has the potential to be a more effective treatment than small molecules because antibodies have been shown to have a more targeted and persistent effect in the body.
In addition to its potential as a drug target, OPN5 has also been identified as a potential biomarker for a variety of diseases. Its expression has been shown to be associated with the development of certain diseases, such as cancer, neurodegenerative disorders, and urological problems. This makes OPN5 a valuable tool for the diagnosis and treatment of these diseases.
OPN5 is also a good candidate as a biomarker for monitoring the effectiveness of certain treatments. By measuring the level of OPN5 in the body, researchers can determine whether a treatment is having the desired effect and make any necessary adjustments.
In conclusion, OPN5 is a protein that has the potential to be a drug target or biomarker for a variety of diseases. Its involvement in many different processes in the body makes it an attractive target for small molecules, antibodies, or vaccines. Its potential as a biomarker for the diagnosis and treatment of diseases also makes it an important tool for researchers to understand the underlying causes of these diseases. Further studies are needed to fully understand the potential of OPN5 as a drug target and biomarker.
Protein Name: Opsin 5
Functions: G-protein coupled receptor which selectively activates G(i) type G proteins via ultraviolet A (UVA) light-mediated activation in the retina (By similarity). Preferentially binds the chromophore 11-cis retinal and is a bistable protein that displays emission peaks at 380 nm (UVA light) and 470 nm (blue light) (PubMed:22043319). Required for the light-response in the inner plexiform layer, and contributes to the regulation of the light-response in the nerve fiber layer, via phosphorylated DAT/SLC6A3 dopamine uptake (By similarity). Involved in local corneal and retinal circadian rhythm photoentrainment via modulation of the UVA light-induced phase-shift of the retina clock (By similarity). Acts as a circadian photoreceptor in the outer ear, via modulation of circadian clock-gene expression in response to violet light during the light-to-dark transition phase and night phase of the circadian cycle (By similarity). Required in the retina to negatively regulate hyaloid vessel regression during postnatal development via light-dependent OPN5-SLC32A1-DRD2-VEGFR2 signaling (By similarity). Involved in the light-dependent regulation of retina and vitreous compartment dopamine levels (By similarity)
The "OPN5 Target / Biomarker Review Report" is a customizable review of hundreds up to thousends of related scientific research literature by AI technology, covering specific information about OPN5 comprehensively, including but not limited to:
• general information;
• protein structure and compound binding;
• protein biological mechanisms;
• its importance;
• the target screening and validation;
• expression level;
• disease relevance;
• drug resistance;
• related combination drugs;
• pharmacochemistry experiments;
• related patent analysis;
• advantages and risks of development, etc.
The report is helpful for project application, drug molecule design, research progress updates, publication of research papers, patent applications, etc. If you are interested to get a full version of this report, please feel free to contact us at BD@silexon.ai
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