Target Name: OPRPN
NCBI ID: G58503
Review Report on OPRPN Target / Biomarker Content of Review Report on OPRPN Target / Biomarker
OPRPN
Other Name(s): proline-rich protein 1 | OPRPN variant 1 | basic proline-rich protein | PRL1 | proline-rich 1 | Proline-rich 1 | BPLP | opiorphin | basic proline-rich lacrimal protein | Opiorphin | Basic proline-rich protein | Basic proline-rich lacrimal protein | PROL1_HUMAN | Opiorphin prepropeptide, transcript variant 1 | opiorphin prepropeptide | Opiorphin prepropeptide | proline rich, lacrimal 1 | Opiorphin prepropeptide (isoform 1) | PROL1

OProPN: A Potential Drug Target and Biomarker

Proline-rich protein 1 (OPRPN) is a protein that is expressed in various tissues of the body, including the brain, heart, and kidneys. It is characterized by the presence of multiple proline residues in its sequence, which give it its unique structural features. While OProPN is not well-studied compared to other proteins, its unique features and subcellular localization suggest that it may play an important role in various biological processes. As a result, OProPN has potential as a drug target or biomarker.

OPPRPN Localization and Subcellular Localization

OPRPN is expressed in a variety of tissues and organs, including the brain, heart, liver, kidney, and pancreas. It is primarily localized to the cytoplasm of these cells and can also be found in the cell membrane and the endoplasmic reticulum. OProPN is also known to be involved in the regulation of various cellular processes, including cell adhesion, migration, and apoptosis.

The unique subcellular localization of OProPN suggests that it may play a role in the regulation of cell-cell interactions and cell-endomembrane system (ER system) processes. The ER system is responsible for the synthesis, folding, and transport of proteins to the cell membrane, and it is a well-established hub for the regulation of various cellular processes, including the regulation of cell adhesion and migration. As OProPN is involved in the regulation of cell adhesion and migration, it may be a potential drug target or biomarker for diseases that are characterized by these processes, such as cancer, neurodegenerative diseases, and autoimmune disorders.

Unique Features and Potential Functions

OPRPN is characterized by its unique features, including the presence of multiple proline residues and the presence of a distinct N-terminal region. The multiple proline residues give OProPN its structural stability and enable it to interact with various cellular components, including other proteins and signaling molecules. The N-terminal region is rich in various domains, including a nuclear localization domain, a cytoplasmic localization domain, and a region that is involved in the regulation of cellular processes, such as cell adhesion and migration.

The unique features of OProPN suggest that it may play a role in the regulation of various cellular processes, including cell adhesion, migration, and apoptosis. It may also be involved in the regulation of cellular signaling pathways, including the TGF-β pathway. TGF -尾 is a well-established signaling pathway that is involved in the regulation of cell growth, differentiation, and survival, and it is a potential target for a variety of diseases, including cancer. As OProPN is involved in the regulation of TGF-β signaling, it may be a potential drug target or biomarker for these diseases.

Expression and Localization of OProPN

OPRPN is expressed in a variety of tissues and organs, including the brain, heart, liver, kidney, and pancreas. Its expression is highest in the brain, where it is involved in the regulation of various cellular processes, including cell adhesion and migration. OProPN is also expressed in other tissues, including the heart, liver, and kidney, where it is involved in the regulation of cellular processes, including cell growth, differentiation, and apoptosis.

While the exact mechanism by which OProPN is involved in the regulation of cellular processes is not well understood, its unique features and subcellular localization suggest that it plays an important role in these processes. As a result, OProPN has potential as a drug target or biomarker for diseases that are characterized by these processes, such as cancer, neurodegenerative diseases, and autoimmune disorders.

Conclusion

OPRPN is a protein that is characterized by its unique features, including the presence of multiple proline residues and a distinct N-terminal region. Its subcellular localization and the regulation

Protein Name: Opiorphin Prepropeptide

Functions: Opiorphin is an endogenous inhibitor of neprilysin and aminopeptidase N. Inhibits the breakdown of substance P, Mca-BK2 and Met-enkephalin by neprilysin in vitro with IC(50) values of 29 uM, 33 uM and 33 uM respectively. Inhibits the breakdown of Ala-pNA by aminopeptidase N in vitro with an IC(50) of 65 uM. Has a potent analgesic effect when administered to rats by intravenous injection

The "OPRPN Target / Biomarker Review Report" is a customizable review of hundreds up to thousends of related scientific research literature by AI technology, covering specific information about OPRPN comprehensively, including but not limited to:
•   general information;
•   protein structure and compound binding;
•   protein biological mechanisms;
•   its importance;
•   the target screening and validation;
•   expression level;
•   disease relevance;
•   drug resistance;
•   related combination drugs;
•   pharmacochemistry experiments;
•   related patent analysis;
•   advantages and risks of development, etc.
The report is helpful for project application, drug molecule design, research progress updates, publication of research papers, patent applications, etc. If you are interested to get a full version of this report, please feel free to contact us at BD@silexon.ai

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