UBAC2: A Potential Drug Target and Biomarker (G337867)

Target Name: UBAC2

NCBI ID: G337867

UBAC2

UBAC2: A Potential Drug Target and Biomarker

Uniprot (Protein Data Bank)

Uniprot is a protein database that contains information on protein structures, functions, and interactions. It is a comprehensive resource for researchers and pharmaceutical companies to study protein behavior and develop new drugs.

UBAC2 (UBA domain containing 2) is a protein that has been identified as a potential drug target and biomarker. It is a key regulator of the microtubule network, which is a complex system of filaments that transports and organizes cells' genetic material. Microtubules play a crucial role in cell division, intracellular transport, and regulation of various cellular processes.

UBAC2 is a 21-kDa protein that consists of 158 amino acid residues. It has a unique structure, with a distinct N-terminal region that contains a UBA domain and a C-terminal region that contains a series of conserved domains, including a GFP-like domain, a TF-like domain, and a putative GTPase domain. The UBA domain is a well-known structural feature that is characterized by a specific type of hydrogen bonding between the A222 residue and the C165 residue.

Functional assays have shown that UBAC2 plays a critical role in regulating microtubule dynamics and stability. It has been shown to interact with a variety of protein partners, including microtubule-associated protein 5 (MAP-5), which is a key regulator of microtubule stability. Additionally, UBAC2 has been shown to interact with the protein T-cell nuclear factor 1 (TNF-1), which is involved in cell signaling and inflammation.

UBAC2 has also been shown to be involved in a variety of cellular processes, including cell division, cell migration, and intracellular transport. It has been shown to play a role in regulating mitosis, meiosis, and neurotransmitter release. In addition, UBAC2 has been shown to be involved in the regulation of cell survival and apoptosis.

As a potential drug target, UBAC2 has been the focus of research in the pharmaceutical industry. Researchers have identified several potential drug compounds that can interact with UBAC2 and have shown that these compounds can inhibit microtubule dynamics and stability. These compounds have been shown to be effective in a variety of cellular assays, including microtubule dynamics assays and cell-based assays of drug sensitivity.

In addition to its potential as a drug target, UBAC2 has also been identified as a potential biomarker. Its unique structure and function have made it an attractive candidate for use as a diagnostic or predictive marker for a variety of diseases. For example, UBAC2 has been shown to be involved in the regulation of cancer cell division and has been identified as a potential biomarker for pancreatic cancer.

UBAC2 is a highly conserved protein that is involved in a variety of cellular processes. Its unique structure and function make it an attractive candidate for use as a drug target and biomarker. Further research is needed to fully understand its role in cellular processes and its potential as a drug and biomarker.

Protein Name: UBA Domain Containing 2

Functions: Restricts trafficking of FAF2 from the endoplasmic reticulum to lipid droplets (PubMed:23297223). In association with LMBR1L and E3 ubiquitin-protein ligase AMFR, negatively regulates the canonical Wnt signaling pathway in the lymphocytes by promoting the ubiquitin-mediated degradation of CTNNB1 and Wnt receptors FZD6 and LRP6 (PubMed:31073040)

The "UBAC2 Target / Biomarker Review Report" is a customizable review of hundreds up to thousends of related scientific research literature by AI technology, covering specific information about UBAC2 comprehensively, including but not limited to:
•   general information;
•   protein structure and compound binding;
•   protein biological mechanisms;
•   its importance;
•   the target screening and validation;
•   expression level;
•   disease relevance;
•   drug resistance;
•   related combination drugs;
•   pharmacochemistry experiments;
•   related patent analysis;
•   advantages and risks of development, etc.
The report is helpful for project application, drug molecule design, research progress updates, publication of research papers, patent applications, etc. If you are interested to get a full version of this report, please feel free to contact us at BD@silexon.ai

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