Understanding INPP4A: A Potential Drug and Biomarker (G3631)

Target Name: INPP4A

NCBI ID: G3631

INPP4A

Understanding INPP4A: A Potential Drug and Biomarker

INPP4A (Inositol polyphosphate-4-phosphatase, type 1) is a protein that is expressed in various tissues throughout the body, including the brain, pancreas, and heart. It is a key enzyme in the intracellular signaling pathway known as the insulin signaling pathway, which is involved in regulating various physiological processes in the body, including metabolism, growth, and development.

INPP4A is a type 1 protein, which means that it is one of the four main types of proteins that can be encoded by a gene. The protein is made up of 21 different amino acids and has a calculated molecular mass of 33.1 kDa.

One of the unique features of INPP4A is its role in the regulation of insulin signaling. Insulin is a hormone that is produced by the pancreas and helps to regulate the levels of glucose (sugar) in the blood. The insulin signaling pathway is a critical pathway that helps to regulate the levels of insulin in the body. INPP4A is a key enzyme in this pathway, and it is involved in the phosphorylation of several key protein substrates that are involved in insulin signaling.

The phosphorylation of protein substrates is a critical process in intracellular signaling. It is a way for cells to communicate with each other and to coordinate their activities. In the case of INPP4A, the phosphorylation of its protein substrates allows it to regulate the levels of insulin in the body.

INPP4A is also involved in the regulation of other signaling pathways that are important for the development and maintenance of tissues in the body. For example, INPP4A is involved in the regulation of cell proliferation, differentiation, and survival. It is also involved in the regulation of inflammation, and it is thought to play a role in the development of certain diseases, such as cancer.

Due to its involvement in several important signaling pathways, INPP4A is a potential drug target. Researchers are currently working to develop drugs that can inhibit the activity of INPP4A and improve insulin sensitivity in individuals with type 2 diabetes. These drugs have the potential to be used to treat a wide range of diseases, including cancer, heart disease, and neurodegenerative diseases.

In addition to its potential as a drug target, INPP4A is also a potential biomarker. The insulin signaling pathway is a critical pathway that is involved in the regulation of many different physiological processes in the body. As such, measuring the levels of INPP4A in the body may be a useful diagnostic tool for certain diseases. For example, INPP4A levels may be elevated in individuals with type 2 diabetes, as a result of the disease-related increase in insulin production by the pancreas.

Overall, INPP4A is a protein that is involved in several important signaling pathways in the body. Its role in the regulation of insulin signaling and other processes makes it a potential drug target and a useful biomarker for the diagnosis and treatment of many different diseases. Further research is needed to fully understand the functions of INPP4A and its potential as a drug and biomarker.

Protein Name: Inositol Polyphosphate-4-phosphatase Type I A

Functions: Catalyzes the hydrolysis of the 4-position phosphate of phosphatidylinositol 3,4-bisphosphate (PtdIns(3,4)P2) (PubMed:20463662, PubMed:15716355). Catalyzes also inositol 1,3,4-trisphosphate and inositol 1,4-bisphosphate (By similarity). Antagonizes the PI3K-AKT/PKB signaling pathway by dephosphorylating phosphoinositides and thereby modulating cell cycle progression and cell survival (PubMed:30071275) (By similarity). May protect neurons from excitotoxic cell death by regulating the synaptic localization of cell surface N-methyl-D-aspartate-type glutamate receptors (NMDARs) and NMDAR-mediated excitatory postsynaptic current (By similarity)

The "INPP4A Target / Biomarker Review Report" is a customizable review of hundreds up to thousends of related scientific research literature by AI technology, covering specific information about INPP4A comprehensively, including but not limited to:
•   general information;
•   protein structure and compound binding;
•   protein biological mechanisms;
•   its importance;
•   the target screening and validation;
•   expression level;
•   disease relevance;
•   drug resistance;
•   related combination drugs;
•   pharmacochemistry experiments;
•   related patent analysis;
•   advantages and risks of development, etc.
The report is helpful for project application, drug molecule design, research progress updates, publication of research papers, patent applications, etc. If you are interested to get a full version of this report, please feel free to contact us at BD@silexon.ai

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