Unlocking The Potential of AQP7: A Protein Involved in Water Regulation and Disease Development

Target Name: AQP7

NCBI ID: G364

AQP7

Unlocking The Potential of AQP7: A Protein Involved in Water Regulation and Disease Development

AQP7 (AQP7L) is a protein that is expressed in various tissues throughout the body, including the brain, heart, kidneys, and intestines. It is a member of the AQP (aquaporin) family, which are characterized by the presence of a water-binding motif in their transmembrane domain.

One of the unique features of AQP7 is its ability to regulate the concentration of water in different cell types. This is achieved through its ability to form a hydrophobic pocket in its transmembrane domain, which is thought to enhance the stability of the protein and prevent it from undergoing hydration-induced conformational changes.

AQP7 has been shown to play a role in a variety of physiological processes in the body, including blood pressure, blood flow, and tissue hydration. For example, studies have shown that AQP7 is involved in regulating blood pressure by increasing the amount of water in the blood and increasing the sensitivity of blood vessels to the pressure.

In addition to its role in blood pressure regulation, AQP7 has also been shown to be involved in the development and progression of various diseases, including cancer, neurodegenerative diseases, and autoimmune disorders. For example, studies have shown that AQP7 is involved in the development of cancer by increasing the amount of water in the cells and increasing the risk of cell survival.

Despite its potential role in a variety of diseases, AQP7 has not yet been identified as a drug target or biomarker. This is because the underlying mechanisms that AQP7 is involved in are not well understood, and there is a need for further research to determine the precise function of this protein.

In conclusion, AQP7 is a protein that is expressed in various tissues throughout the body and is involved in the regulation of water concentration in different cell types. Its unique ability to form a hydrophobic pocket in its transmembrane domain and its involvement in various physiological processes in the body make it a promising candidate for future research as a drug target or biomarker. Further studies are needed to fully understand the function of AQP7 and its potential role in disease.

Protein Name: Aquaporin 7

Functions: Forms a channel that mediates water and glycerol transport across cell membranes at neutral pH (PubMed:9405233, PubMed:11952783, PubMed:30423801, PubMed:30420639). The channel is also permeable to urea (PubMed:9405233). Plays an important role in body energy homeostasis under conditions that promote lipid catabolism, giving rise to glycerol and free fatty acids. Mediates glycerol export from adipocytes. After release into the blood stream, glycerol is used for gluconeogenesis in the liver to maintain normal blood glucose levels and prevent fasting hypoglycemia. Required for normal glycerol reabsorption in the kidney (By similarity)

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•   general information;
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•   protein biological mechanisms;
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•   the target screening and validation;
•   expression level;
•   disease relevance;
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•   pharmacochemistry experiments;
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