ARF1: A Potential Drug Target and Biomarker for Diseases (G375)

Target Name: ARF1

NCBI ID: G375

ARF1

ARF1: A Potential Drug Target and Biomarker for Diseases

ARF1 (ADP Ribosylation Factor 1) is a protein that plays a crucial role in cell signaling pathways. It is a key regulator of the RNA polymerase II (RNA-II) complex, which is responsible for synthesizing proteins from RNA templates. ARF1 functions as a scaffold protein that helps to ensure the proper assembly and function of the RNA-II complex. It also functions as a protein-protein interaction (PPI) partner, which allows it to interact with other proteins and factors that regulate the RNA-II complex.

ARF1 has been identified as a potential drug target and a biomarker for various diseases, including cancer, neurodegenerative diseases, and autoimmune diseases. The ability of ARF1 to regulate the RNA-II complex and its role in cell signaling pathways make it an attractive target for small molecule inhibitors.

One of the main reasons for the potential of ARF1 as a drug target is its high degree of complexity and the various functions it plays in different cellular processes. The RNA-II complex is a large protein complex that includes multiple subunits, and ARF1 is one of the key regulators that ensures its proper function. The complexity of the RNA-II complex makes it difficult to identify small molecules that can inhibit its activity without also affecting the activity of other proteins.

Additionally, ARF1 is involved in various signaling pathways that are involved in the development and progression of many diseases. For example, ARF1 is involved in the regulation of the cell cycle, which is critical for the development and progression of cancer. It also plays a role in the regulation of cell adhesion, which is important for the development and progression of neurodegenerative diseases.

Another potential mechanism by which ARF1 can be targeted as a drug is its role as a biomarker. The ability of ARF1 to regulate the RNA-II complex makes it a useful biomarker for evaluating the efficacy of small molecule inhibitors. By measuring the levels of ARF1 in cells or tissues, researchers can determine the effectiveness of different small molecule inhibitors. This can be a valuable tool for the development of new treatments for diseases.

In addition to its potential as a drug target and biomarker, ARF1 also has important structural and functional roles in various cellular processes. It is a key regulator of the RNA-II complex, which is responsible for synthesizing proteins from RNA templates. The RNA-II complex is a large protein complex that includes multiple subunits, and ARF1 is one of the key regulators that ensures its proper function.

ARF1 is involved in the regulation of various cellular processes, including the cell cycle, cell adhesion, and DNA replication. It is a key regulator of the cell cycle, which is responsible for the repetitive division of cells. ARF1 helps to ensure that the cell cycle is properly regulated, which is essential for the development and progression of cancer. It is also involved in the regulation of cell adhesion, which is important for the development and progression of neurodegenerative diseases.

In conclusion, ARF1 is a protein that plays a crucial role in cell signaling pathways and has various functions in different cellular processes. Its complexity and the various functions it plays make it an attractive target for small molecule inhibitors. The potential of ARF1 as a drug target and biomarker make it a valuable tool for the development of new treatments for various diseases.

Protein Name: ADP Ribosylation Factor 1

Functions: Small GTPase involved in protein trafficking between different compartments (PubMed:8253837). Modulates vesicle budding and uncoating within the Golgi complex (PubMed:8253837). In its GTP-bound form, triggers the recruitment of coatomer proteins to the Golgi membrane (PubMed:8253837). The hydrolysis of ARF1-bound GTP, which is mediated by ARFGAPs proteins, is required for dissociation of coat proteins from Golgi membranes and vesicles (PubMed:8253837). The GTP-bound form interacts with PICK1 to limit PICK1-mediated inhibition of Arp2/3 complex activity; the function is linked to AMPA receptor (AMPAR) trafficking, regulation of synaptic plasticity of excitatory synapses and spine shrinkage during long-term depression (LTD) (By similarity)

The "ARF1 Target / Biomarker Review Report" is a customizable review of hundreds up to thousends of related scientific research literature by AI technology, covering specific information about ARF1 comprehensively, including but not limited to:
•   general information;
•   protein structure and compound binding;
•   protein biological mechanisms;
•   its importance;
•   the target screening and validation;
•   expression level;
•   disease relevance;
•   drug resistance;
•   related combination drugs;
•   pharmacochemistry experiments;
•   related patent analysis;
•   advantages and risks of development, etc.
The report is helpful for project application, drug molecule design, research progress updates, publication of research papers, patent applications, etc. If you are interested to get a full version of this report, please feel free to contact us at BD@silexon.ai

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