KCNA4: Key Enzyme in Intracellular Signaling and Cellular Processes

Target Name: KCNA4

NCBI ID: G3739

KCNA4

KCNA4: Key Enzyme in Intracellular Signaling and Cellular Processes

KCNA4 (K-TypeNa+-ATPase) is a protein that is expressed in various tissues and cells in the body. It is a key enzyme in the transport system of intracellular signaling, which is responsible for the delivery of various signaling molecules to their respective targets . KCNA4 is also involved in the regulation of ion channels and the production of reactive oxygen species, which can have a damage on cellular health if not controlled.

KCNA4 is a member of the family of Na+-ATPase, which is a subfamily of cation transport proteins. These proteins are characterized by the presence of a catalytic site in the form of a nucleotide-binding oligomerization domain (NBD), which is responsible for the binding of nucleotides. The NBD is responsible for the transfer of phosphate groups from ATP to the protein, which is then used to regulate various cellular processes.

KCNA4 is a 126-amino acid protein that has a calculated molecular mass of 17.9 kDa. It is expressed in various tissues, including the brain, heart, and kidney, and is involved in the regulation of a wide range of cellular processes.

One of the key functions of KCNA4 is its role in intracellular signaling. It is involved in the regulation of ion channels, which are responsible for the delivery of various signaling molecules to their respective targets. For example, KCNA4 is involved in the regulation of sodium channels, which are responsible for the delivery of action potentials to the cell surface.

In addition to its role in ion channel regulation, KCNA4 is also involved in the production of reactive oxygen species. These reactive oxygen species, such as superoxide and hypoxia, can have a detrimental effect on cellular health if not controlled. of these reactive oxygen species through its role in the regulation of antioxidant enzymes, such as superoxide dismutase.

Another function of KCNA4 is its role in the regulation of cellular signaling pathways. It is involved in the regulation of various signaling pathways, including the TGF-β pathway, which is involved in the regulation of cell growth and differentiation.

KCNA4 is also involved in the regulation of cellular transport processes. It is involved in the regulation of the transport of various molecules, including neurotransmitters and hormones.

In conclusion, KCNA4 is a protein that is involved in a wide range of cellular processes. Its role in intracellular signaling, ion channel regulation, and the production of reactive oxygen species makes it an attractive drug target. Further research is needed to fully understand the role of KCNA4 in cellular signaling and to develop effective therapies that target this protein.

Protein Name: Potassium Voltage-gated Channel Subfamily A Member 4

Functions: Voltage-gated potassium channel that mediates transmembrane potassium transport in excitable membranes. Forms tetrameric potassium-selective channels through which potassium ions pass in accordance with their electrochemical gradient. The channel alternates between opened and closed conformations in response to the voltage difference across the membrane (PubMed:19912772, PubMed:8495559). Can form functional homotetrameric channels and heterotetrameric channels that contain variable proportions of KCNA1, KCNA2, KCNA4, KCNA5, and possibly other family members as well; channel properties depend on the type of alpha subunits that are part of the channel (PubMed:8495559). Channel properties are modulated by cytoplasmic beta subunits that regulate the subcellular location of the alpha subunits and promote rapid inactivation. In vivo, membranes probably contain a mixture of heteromeric potassium channel complexes, making it difficult to assign currents observed in intact tissues to any particular potassium channel family member. Homotetrameric KCNA4 forms a potassium channel that opens in response to membrane depolarization, followed by rapid spontaneous channel closure (PubMed:19912772, PubMed:8495559). Likewise, a heterotetrameric channel formed by KCNA1 and KCNA4 shows rapid inactivation (PubMed:17156368)

The "KCNA4 Target / Biomarker Review Report" is a customizable review of hundreds up to thousends of related scientific research literature by AI technology, covering specific information about KCNA4 comprehensively, including but not limited to:
•   general information;
•   protein structure and compound binding;
•   protein biological mechanisms;
•   its importance;
•   the target screening and validation;
•   expression level;
•   disease relevance;
•   drug resistance;
•   related combination drugs;
•   pharmacochemistry experiments;
•   related patent analysis;
•   advantages and risks of development, etc.
The report is helpful for project application, drug molecule design, research progress updates, publication of research papers, patent applications, etc. If you are interested to get a full version of this report, please feel free to contact us at BD@silexon.ai

More Common Targets