KCTD13: A Protein Involved in RhoA Degradation and Stability (G253980)

Target Name: KCTD13

NCBI ID: G253980

KCTD13

KCTD13: A Protein Involved in RhoA Degradation and Stability

KCTD13, also known as BTB/POZ domain-containing adapter for CUL3-mediated RhoA degradation protein 1, is a protein that is of interest in the field of molecular biology and protein degradation. It is a member of the BTB/POZ domain family, which is known for their role in protein-protein interactions and in the regulation of protein stability. KCTD13 has been shown to play a role in the regulation of the degradation of the protein RhoA, which is a key regulator of cell signaling pathways.

In recent years, the study of protein degradation has become an increasingly important area of research, as the regulation of protein stability and degradation is involved in many cellular processes that are important for cell survival. One of the proteins that is particularly well-studied in this area is RhoA, which is a key regulator of the Rho GTPase signaling pathway. This pathway is involved in the regulation of cell signaling pathways, including the regulation of cell growth, differentiation, and survival.

KCTD13 has been shown to play a role in the regulation of RhoA degradation, which is the process by which RhoA is removed from the cell. KCTD13 is a protein that is specifically designed to interact with the BTB/POZ domain of RhoA, which is located on the protein RhoA. This interaction between KCTD13 and RhoA allows KCTD13 to regulate the degradation of RhoA.

In addition to its role in regulating RhoA degradation, KCTD13 has also been shown to play a role in the regulation of other proteins. For example, KCTD13 has been shown to interact with the protein Fyn, which is involved in the regulation of cell signaling pathways. This interaction between KCTD13 and Fyn allows KCTD13 to regulate the degradation of Fyn.

KCTD13 is also involved in the regulation of protein stability, as it has been shown to interact with the protein stability regulator, known as the N-end rule. This interaction between KCTD13 and the N-end rule allows KCTD13 to regulate the stability of other proteins, including RhoA.

In conclusion, KCTD13 is a protein that is of interest in the field of molecular biology and protein degradation. Its role in the regulation of RhoA degradation and stability makes it an attractive drug target or biomarker for future research. Further studies are needed to fully understand the mechanisms of KCTD13's role in protein degradation and to determine its potential as a drug or biomarker.

Protein Name: Potassium Channel Tetramerization Domain Containing 13

Functions: Substrate-specific adapter of a BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex required for synaptic transmission (PubMed:19782033). The BCR(KCTD13) E3 ubiquitin ligase complex mediates the ubiquitination of RHOA, leading to its degradation by the proteasome (PubMed:19782033) Degradation of RHOA regulates the actin cytoskeleton and promotes synaptic transmission (By similarity)

The "KCTD13 Target / Biomarker Review Report" is a customizable review of hundreds up to thousends of related scientific research literature by AI technology, covering specific information about KCTD13 comprehensively, including but not limited to:
•   general information;
•   protein structure and compound binding;
•   protein biological mechanisms;
•   its importance;
•   the target screening and validation;
•   expression level;
•   disease relevance;
•   drug resistance;
•   related combination drugs;
•   pharmacochemistry experiments;
•   related patent analysis;
•   advantages and risks of development, etc.
The report is helpful for project application, drug molecule design, research progress updates, publication of research papers, patent applications, etc. If you are interested to get a full version of this report, please feel free to contact us at BD@silexon.ai

More Common Targets