Target Name: MIR142
NCBI ID: G406934
Review Report on MIR142 Target / Biomarker Content of Review Report on MIR142 Target / Biomarker
MIR142
Other Name(s): hsa-mir-142 | mir-142 | MIRN142 | microRNA 142 | hsa-miR-142-3p | hsa-miR-142-5p | MicroRNA 142

MIR142: A Potential Drug Target and Biomarker for Chronic Pain

Introduction

Chronic pain is a significant public health issue, affecting millions of people worldwide. The persistent nature of pain can have a significant impact on an individual's quality of life, and can even lead to disability and mental health problems. The gold standard treatments include medications Treatment, surgery, and physical therapy, etc., but often cannot completely eliminate pain. Therefore, finding new treatments is of great clinical significance. In recent years, people's interest in gene therapy, a method of treating diseases through genetic engineering technology, has gradually increased, bringing new hope to the treatment of chronic pain. MIR142 is one of the gene therapy targets currently attracting much attention and has significant potential to become a drug target or biomarker. This article will introduce the relevant research progress of MIR142 and explore its clinical application prospects.

Discovery and expression of MIR142 gene

MIR142 is a gene encoding an N-terminal 伪-helical domain (N-伪) and a member of the Hsp70 family. The N-伪 domain has important biological functions in cells and can combine with other proteins to form complex biomolecular networks. Studies have found that in many types of chronic pain, the expression level of the MIR142 gene is significantly higher than that in normal tissue. This brings new clues to the role of MIR142 gene in chronic pain treatment.

Function and expression of MIR142 gene

Functional research on the MIR142 gene mainly focuses on the following aspects:

1. Pain signal transduction: The protein encoded by the MIR142 gene is an N-terminal 伪-helical domain, which has unique biological activity. Studies have shown that knockdown of the MIR142 gene leads to higher pain perception in mice in preparation models, indicating that the MIR142 gene plays an important role in pain signal transduction.

2. Neuroprotection: The protein expressed by the MIR142 gene plays an important role in neuroprotection. The study found that the neurons of MIR142 knockout mice significantly increased neuronal loss and synaptic plasticity after being subjected to ischemic stimulation, while mice with MIR142 overexpression showed better neuronal survival and plasticity. This indicates that the MIR142 gene plays an important role in neuroprotection.

3. Immune regulation: The protein encoded by the MIR142 gene also has immunomodulatory effects. Studies have found that the protein expressed by the MIR142 gene can regulate the function of immune cells, thereby affecting the balance of the immune system. These studies provide new evidence for the role of MIR142 gene in immune regulation.

Clinical application prospects of MIR142 gene

The role of the MIR142 gene in the treatment of chronic pain has attracted widespread attention. Currently, some research teams are exploring the application of MIR142 gene therapy technology in chronic pain treatment. Through genetic engineering technology, the expression product of the MIR142 gene can be converted into drugs for the treatment of chronic pain.

1. Drug research and development: MIR142 gene can be used as a drug target for drug treatment. The study found that MIR142 gene knockout mice produced significantly higher pain sensations in the model than MIR142 gene overexpression mice, which means that the protein encoded by the MIR142 gene can be used as a drug target for the treatment of chronic pain. Currently, some research teams are exploring converting the protein of the MIR142 gene into drugs to treat different types of chronic pain, such as neuralgia, rheumatoid arthritis, etc.

2. Biomarker: The MIR142 gene can also be used as a biomarker for chronic pain. The study found that increased expression levels of the MIR142 gene can be used to evaluate the extent of chronic pain and the effectiveness of treatment. This provides new evidence for the role of the MIR142 gene in the diagnosis and treatment of chronic pain.

in conclusion

The MIR142 gene has significant potential in chronic pain treatment. Through genetic engineering technology, the expression product of the MIR142 gene can be converted into drugs for the treatment of chronic pain. In addition, the MIR142 gene can also be used as a biomarker for chronic pain to evaluate the effectiveness of treatment.

Protein Name: MicroRNA 142

The "MIR142 Target / Biomarker Review Report" is a customizable review of hundreds up to thousends of related scientific research literature by AI technology, covering specific information about MIR142 comprehensively, including but not limited to:
•   general information;
•   protein structure and compound binding;
•   protein biological mechanisms;
•   its importance;
•   the target screening and validation;
•   expression level;
•   disease relevance;
•   drug resistance;
•   related combination drugs;
•   pharmacochemistry experiments;
•   related patent analysis;
•   advantages and risks of development, etc.
The report is helpful for project application, drug molecule design, research progress updates, publication of research papers, patent applications, etc. If you are interested to get a full version of this report, please feel free to contact us at BD@silexon.ai

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