hK14 as A Potential Drug Target Or Biomarker for Neurological Disorders

Target Name: KLK14

NCBI ID: G43847

KLK14

hK14 as A Potential Drug Target Or Biomarker for Neurological Disorders

KLK14 (hK14), a gene that encodes a protein known as KLK14, is a key regulator of various cellular processes that occur in the brain. The protein encoded by hK14 has been shown to play a crucial role in the development and maintenance of neuronal structure and function. Based on these findings, hK14 has potential as a drug target or biomarker for various neurological and psychiatric disorders.

The hK14 gene encodes a protein that is composed of 194 amino acid residues. The protein has a molecular weight of 21.1 kDa and a calculated pI of 1.85. The hK14 protein is expressed in various tissues and cells, including brain, heart, and muscle. It is highly expressed in the brain, with the highest expression levels found in the cortical regions of the brain.

The hK14 protein is involved in various cellular processes that are critical for neuronal development, migration, and maintenance. One of the most significant functions of hK14 is its role in the development and maintenance of neuronal structure. hK14 has been shown to play a critical role in the formation of axons, which are the long, thread-like structures that carry nerve signals away from the cell body to other neurons.

In addition to its role in the formation of axons, hK14 is also involved in the regulation of neuronal growth and differentiation. It has been shown to play a critical role in the regulation of cell proliferation, survival, and death. hK14 has been shown to promote the survival and proliferation of neuronal cells, and it has been shown to inhibit the programmed cell death that is associated with neurodegenerative diseases.

The hK14 protein is also involved in the regulation of neuronal communication. It has been shown to play a critical role in the regulation of synaptic plasticity, which is the ability of the nervous system to change and adapt over time. hK14 has been shown to regulate the formation of new synapses, which are the connections between neurons.

In addition to its role in the regulation of neuronal communication, hK14 is also involved in the regulation of inflammation. It has been shown to play a critical role in the regulation of immune cell function, which is important for the immune system's response to infection and inflammation.

The hK14 gene has also been shown to be involved in the development and maintenance of various psychiatric and neurological disorders. For example, hK14 has been shown to be involved in the development of Alzheimer's disease, which is a progressive neurodegenerative disorder that is characterized by the accumulation of neurofibrillary tangles and beta-amyloid plaques in the brain.

In addition to its involvement in the development of Alzheimer's disease, hK14 has also been shown to be involved in the development of other neurological disorders, including Parkinson's disease, which is a neurodegenerative disorder that is characterized by the loss of dopamine-producing neurons in the brain.

Based on these findings, hK14 has potential as a drug target or biomarker for various neurological and psychiatric disorders. The development of drugs that target hK14 and its associated proteins may provide new treatments for a variety of neurological and psychiatric disorders.

Protein Name: Kallikrein Related Peptidase 14

Functions: Serine-type endopeptidase with a dual trypsin-like and chymotrypsin-like substrate specificity. May activate/inactivate the proteinase-activated receptors F2R, F2RL1 and F2RL3 and other kallikreins including KLK1, KLK3, KLK5 and KLK11. May function in seminal clot liquefaction through direct cleavage of the semenogelin SEMG1 and SEMG2 and activation of KLK3. May function through desmoglein DSG1 cleavage in epidermal desquamation a process by which the most superficial corneocytes are shed from the skin surface. May be involved in several aspects of tumor progression including growth, invasion and angiogenesis

The "KLK14 Target / Biomarker Review Report" is a customizable review of hundreds up to thousends of related scientific research literature by AI technology, covering specific information about KLK14 comprehensively, including but not limited to:
•   general information;
•   protein structure and compound binding;
•   protein biological mechanisms;
•   its importance;
•   the target screening and validation;
•   expression level;
•   disease relevance;
•   drug resistance;
•   related combination drugs;
•   pharmacochemistry experiments;
•   related patent analysis;
•   advantages and risks of development, etc.
The report is helpful for project application, drug molecule design, research progress updates, publication of research papers, patent applications, etc. If you are interested to get a full version of this report, please feel free to contact us at BD@silexon.ai

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