KRT16P2: A Potential Drug Target and Biomarker (G400578)

KRT16P2: A Potential Drug Target and Biomarker

Keratin 16 (K16) is a cytoskeletal protein that plays a crucial role in the organization and maintenance of the hair follicle. It is composed of two isoforms, K16伪2 and K16尾2, which differ in their amino acid sequence. The hair follicle is the terminal organ of hair growth and shedding, and it is responsible for the production of new hair strands. The K16 gene is located on chromosome 16p and encodes the K16 protein.

In recent years, researchers have discovered that K16伪2 is a potential drug target and biomarker for various diseases, including cancer, neurodegenerative diseases, and autoimmune disorders. This is due to its unique structure and function in the cell.

K16伪2 is a 21-kDa protein that contains 115 amino acids. It is expressed in various tissues, including hair follicles, skin, heart, and brain. It is involved in the regulation of cell growth, differentiation, and survival.

One of the most significant functions of K16伪2 is its role in the regulation of the cell cycle. It is a component of the microtubules, which are the cytoskeletal structures that organize the chromosomes during the cell cycle. K16伪2 helps to maintain the integrity of the microtubules and is required for the proper execution of the cell cycle.

In addition to its role in the cell cycle, K16伪2 has also been shown to play a role in various signaling pathways. It has been shown to be involved in the regulation of cell adhesion, migration, and invasion. It has also been shown to play a role in the regulation of inflammation and immune response.

K16伪2 has also been shown to be involved in the development and progression of various diseases, including cancer. For example, studies have shown that K16伪2 is overexpressed in various types of cancer, including breast, ovarian, and prostate cancer. This increased expression of K16伪2 has been shown to promote the growth and survival of cancer cells.

In addition to its potential as a drug target, K16伪2 has also been shown to be a potential biomarker for various diseases. For example, it has been shown to be involved in the development of Alzheimer's disease, a neurodegenerative disorder. This is because K16伪2 is expressed in the brain and has been shown to be involved in the regulation of neurodegeneration.

In conclusion, K16伪2 is a unique and functionally diverse protein that has the potential to be a drug target and biomarker for various diseases. Its role in the regulation of the cell cycle, signaling pathways, and disease development makes it an attractive target for research and development of new treatments. Further studies are needed to fully understand the role of K16伪2 in the regulation of the hair follicle and various diseases.

Protein Name: Keratin 16 Pseudogene 2

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More Common Targets

KRT16P3 | KRT16P6 | KRT17 | KRT17P1 | KRT17P2 | KRT17P3 | KRT17P5 | KRT17P7 | KRT18 | KRT18P1 | KRT18P12 | KRT18P13 | KRT18P16 | KRT18P17 | KRT18P19 | KRT18P22 | KRT18P23 | KRT18P24 | KRT18P27 | KRT18P28 | KRT18P29 | KRT18P31 | KRT18P33 | KRT18P34 | KRT18P4 | KRT18P40 | KRT18P41 | KRT18P42 | KRT18P44 | KRT18P48 | KRT18P49 | KRT18P5 | KRT18P50 | KRT18P51 | KRT18P55 | KRT18P59 | KRT18P6 | KRT18P62 | KRT19 | KRT19P2 | KRT19P3 | KRT2 | KRT20 | KRT222 | KRT23 | KRT24 | KRT25 | KRT26 | KRT27 | KRT28 | KRT3 | KRT31 | KRT32 | KRT33A | KRT33B | KRT34 | KRT35 | KRT36 | KRT37 | KRT38 | KRT39 | KRT4 | KRT40 | KRT42P | KRT5 | KRT6A | KRT6B | KRT6C | KRT7 | KRT7-AS | KRT71 | KRT72 | KRT73 | KRT73-AS1 | KRT74 | KRT75 | KRT76 | KRT77 | KRT78 | KRT79 | KRT8 | KRT80 | KRT81 | KRT82 | KRT83 | KRT84 | KRT85 | KRT86 | KRT87P | KRT89P | KRT8P10 | KRT8P11 | KRT8P12 | KRT8P14 | KRT8P16 | KRT8P17 | KRT8P18 | KRT8P22 | KRT8P23 | KRT8P25