Target Name: KRT1
NCBI ID: G3848
Review Report on KRT1 Target / Biomarker Content of Review Report on KRT1 Target / Biomarker
KRT1
Other Name(s): CK-1 | cytokeratin 1 | hair alpha protein | Keratin 1 | type-II keratin Kb1 | 67 kDa cytokeratin | EHK1 | Cytokeratin 1 | Cytokeratin-1 | Keratin, type II cytoskeletal 1 | Keratin-1 | EPPK | KRT1A | keratin 1 | CK1 | keratin 1, type II | EHK | K2C1_HUMAN | K1 | epidermolytic hyperkeratosis 1 | NEPPK | Type-II keratin Kb1 | Hair alpha protein

KRT1: Key Enzyme in ECM Degradation and Regeneration

KRT1 (Kidney proteinase 1), also known as CK-1, is a protein that is expressed in the kidneys and other organs. It is a key enzyme in the regulation of extracellular matrix (ECM) components, which are the building blocks of tissues and organs. KRT1 plays a crucial role in the degradation of ECM components, such as collagen and laminin, which are removed from the kidneys during the process of renal function.

KRT1 is a 26-kDa protein that is expressed in the brush border of the kidney. It is localized to the basal layer of the epithelial cells in the kidney and is involved in the degradation of ECM components that have accumulated in the renal interstitium. KRT1 is also expressed in other tissues and organs, including the liver, heart, and lungs.

KRT1's role in ECM degradation is essential for maintaining tissue homeostasis and preventing pathological changes. The ECM is a dynamic structure that provides structural support and contributes to tissue mechanical properties. However, when the ECM is damaged or degraded, it can lead to a variety of diseases, including chronic kidney disease, neuropathy, and cancer.

KRT1's role in ECM degradation is also important for regenerative processes. After injury or damage to the kidneys, the body responds by recruiting new cells to repair the damaged tissue. The new cells that are recruited to the site of injury are required to adhere to the ECM and begin to regenerate. KRT1's role in this process is to ensure that the new cells are able to effectively interact with the ECM and begin to generate new tissue.

KRT1 is also a potential drug target for several diseases. Its role in ECM degradation makes it a potential target for diseases that are characterized by inflammation or fibrosis. For example, several studies have suggested that KRT1 may be involved in the development and progression of chronic kidney disease (CKD), which is a leading cause of morbidity and mortality worldwide.

In addition to its potential as a drug target, KRT1 is also a potential biomarker for several diseases. Its role in ECM degradation makes it a potential indicator of disease severity in patients with CKD. For example, higher levels of KRT1 have been associated with greater severity of symptoms and poorer prognosis in patients with advanced CKD.

KRT1 has also been shown to be involved in several cellular processes that are important for human health. For example, KRT1 has been shown to play a role in the regulation of cell adhesion, which is important for the development and maintenance of tissues and organs. Additionally, KRT1 has been shown to play a role in the regulation of cell proliferation, which is important for the growth and development of tissues and organs.

In conclusion, KRT1 is a protein that is involved in several critical processes that are essential for human health. Its role in ECM degradation and its potential as a drug target and biomarker make it an attractive target for research into the mechanisms of several diseases. Further studies are needed to fully understand the role of KRT1 in human health and to develop effective treatments for diseases that are characterized by inflammation or fibrosis.

Protein Name: Keratin 1

Functions: May regulate the activity of kinases such as PKC and SRC via binding to integrin beta-1 (ITB1) and the receptor of activated protein C kinase 1 (RACK1). In complex with C1QBP is a high affinity receptor for kininogen-1/HMWK

The "KRT1 Target / Biomarker Review Report" is a customizable review of hundreds up to thousends of related scientific research literature by AI technology, covering specific information about KRT1 comprehensively, including but not limited to:
•   general information;
•   protein structure and compound binding;
•   protein biological mechanisms;
•   its importance;
•   the target screening and validation;
•   expression level;
•   disease relevance;
•   drug resistance;
•   related combination drugs;
•   pharmacochemistry experiments;
•   related patent analysis;
•   advantages and risks of development, etc.
The report is helpful for project application, drug molecule design, research progress updates, publication of research papers, patent applications, etc. If you are interested to get a full version of this report, please feel free to contact us at BD@silexon.ai

More Common Targets

KRT10 | KRT10-AS1 | KRT12 | KRT126P | KRT13 | KRT14 | KRT15 | KRT16 | KRT16P1 | KRT16P2 | KRT16P3 | KRT16P6 | KRT17 | KRT17P1 | KRT17P2 | KRT17P3 | KRT17P5 | KRT17P7 | KRT18 | KRT18P1 | KRT18P12 | KRT18P13 | KRT18P16 | KRT18P17 | KRT18P19 | KRT18P22 | KRT18P23 | KRT18P24 | KRT18P27 | KRT18P28 | KRT18P29 | KRT18P31 | KRT18P33 | KRT18P34 | KRT18P4 | KRT18P40 | KRT18P41 | KRT18P42 | KRT18P44 | KRT18P48 | KRT18P49 | KRT18P5 | KRT18P50 | KRT18P51 | KRT18P55 | KRT18P59 | KRT18P6 | KRT18P62 | KRT19 | KRT19P2 | KRT19P3 | KRT2 | KRT20 | KRT222 | KRT23 | KRT24 | KRT25 | KRT26 | KRT27 | KRT28 | KRT3 | KRT31 | KRT32 | KRT33A | KRT33B | KRT34 | KRT35 | KRT36 | KRT37 | KRT38 | KRT39 | KRT4 | KRT40 | KRT42P | KRT5 | KRT6A | KRT6B | KRT6C | KRT7 | KRT7-AS | KRT71 | KRT72 | KRT73 | KRT73-AS1 | KRT74 | KRT75 | KRT76 | KRT77 | KRT78 | KRT79 | KRT8 | KRT80 | KRT81 | KRT82 | KRT83 | KRT84 | KRT85 | KRT86 | KRT87P | KRT89P