KPNA4: A Key Regulator of The Nervous System (G3840)

Target Name: KPNA4

NCBI ID: G3840

KPNA4

KPNA4: A Key Regulator of The Nervous System

KPNA4 (IMA3_HUMAN), also known as KPNA4 protein, is a protein that is expressed in various tissues of the human body. It is a key regulator of the nervous system and has been identified as a potential drug target in the treatment of various neurological disorders.

KPNA4 is a transmembrane protein that is involved in the regulation of ion channels and neurotransmitter release in the central nervous system. It is a member of the K-type channels, which are a family of voltage-dependent ion channels that are involved in the regulation of electrical activity in the nervous system. KPNA4 is expressed in the brain and other nervous tissues and is involved in the regulation of ion channels, including those that are responsible for neurotransmitter release.

One of the key functions of KPNA4 is its role in the regulation of neurotransmitter release. Neurotransmitters are chemical messengers that are used by the nervous system to communicate with other cells and tissues. KPNA4 is involved in the regulation of the release of neurotransmitters, including dopamine, serotonin, and endocannabinoids. This is important for the proper functioning of the nervous system and for the regulation of various physiological processes that are critical for human health.

KPNA4 is also involved in the regulation of ion channels that are responsible for the flow of electrical current through the nervous system. This is important for the regulation of the electrical activity that is responsible for the transmission of signals throughout the nervous system.

In addition to its role in the regulation of neurotransmitter release and ion channels, KPNA4 is also involved in the regulation of various signaling pathways that are involved in the development and maintenance of nervous system function. This is important for the regulation of growth, development, and repair of the nervous system, as well as the regulation of pain perception and other physiological processes that are critical for human health.

The potential drug targets for KPNA4 are numerous, and research is ongoing to determine the full range of functions that this protein is involved in. One of the key goals of research into KPNA4 is to identify small molecules that can modulate its activity and have therapeutic effects on the nervous system. This is an important area of research because the regulation of ion channels and neurotransmitter release is a critical aspect of nervous system function, and small molecules that can modulate the activity of KPNA4 may have a wide range of therapeutic applications.

In addition to its potential therapeutic applications, KPNA4 is also an important biomarker for the diagnosis and prognosis of various neurological disorders. The regulation of ion channels and neurotransmitter release is a critical aspect of the development and progression of many neurological disorders, including Parkinson's disease, Alzheimer's disease, and other neurodegenerative disorders. Therefore, the regulation of KPNA4 activity may be a useful biomarker for the diagnosis and prognosis of these disorders.

Overall, KPNA4 (IMA3_HUMAN) is a protein that is involved in the regulation of ion channels and neurotransmitter release in the central nervous system. It is a potential drug target and a useful biomarker for the diagnosis and prognosis of various neurological disorders. Further research is needed to fully understand the role of KPNA4 in the regulation of nervous system function and to identify small molecules that can modulate its activity.

Protein Name: Karyopherin Subunit Alpha 4

Functions: Functions in nuclear protein import as an adapter protein for nuclear receptor KPNB1. Binds specifically and directly to substrates containing either a simple or bipartite NLS motif. Docking of the importin/substrate complex to the nuclear pore complex (NPC) is mediated by KPNB1 through binding to nucleoporin FxFG repeats and the complex is subsequently translocated through the pore by an energy requiring, Ran-dependent mechanism. At the nucleoplasmic side of the NPC, Ran binds to importin-beta and the three components separate and importin-alpha and -beta are re-exported from the nucleus to the cytoplasm where GTP hydrolysis releases Ran from importin. The directionality of nuclear import is thought to be conferred by an asymmetric distribution of the GTP- and GDP-bound forms of Ran between the cytoplasm and nucleus. In vitro, mediates the nuclear import of human cytomegalovirus UL84 by recognizing a non-classical NLS. In vitro, mediates the nuclear import of human cytomegalovirus UL84 by recognizing a non-classical NLS

The "KPNA4 Target / Biomarker Review Report" is a customizable review of hundreds up to thousends of related scientific research literature by AI technology, covering specific information about KPNA4 comprehensively, including but not limited to:
•   general information;
•   protein structure and compound binding;
•   protein biological mechanisms;
•   its importance;
•   the target screening and validation;
•   expression level;
•   disease relevance;
•   drug resistance;
•   related combination drugs;
•   pharmacochemistry experiments;
•   related patent analysis;
•   advantages and risks of development, etc.
The report is helpful for project application, drug molecule design, research progress updates, publication of research papers, patent applications, etc. If you are interested to get a full version of this report, please feel free to contact us at BD@silexon.ai

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