KRBA2: A Potential Drug Target and Biomarker (G124751)
KRBA2: A Potential Drug Target and Biomarker
KRBA2, also known as KRAB-A domain-containing protein 2 (isoform a), is a protein that has been identified as a potential drug target and biomarker. The KRBA2 protein is a member of the KRAB family of proteins, which are known for their role in cell signaling pathways. KRAB-A domain-containing proteins are a subfamily of KRAB proteins that contain an N-terminal KRAB-A domain and a C-terminal protein-coding region.
The KRBA2 protein is unique due to its structure and function. It has a molecular weight of 119 kDa and a pre-folds state of 4.5 kDa. It has a single transmembrane segment and a N-terminal cytoplasmic tail. KRBA2 has been shown to play a role in cell signaling pathways, specifically in the regulation of cell adhesion, migration and invasion.
One of the most significant findings related to KRBA2 is its potential as a drug target. KRBA2 has been shown to interact with several protein tyros, including PDGF-1, PDGF-2, PDGF-3 and PDGF-4 in the PDGF signaling pathway. These interactions suggest that KRBA2 may play a role in the regulation of PDGF signaling pathway, which is a well-established pathway involved in many cellular processes, including cell growth, differentiation, and survival.
Additionally, KRBA2 has also been shown to interact with the protein SMAD4, which is a known regulator of gene expression. This interaction suggests that KRBA2 may be involved in the regulation of gene expression, which is a critical process for the development and maintenance of cellular functions.
Another potential function of KRBA2 is its role as a biomarker. The KRBA2 protein has been shown to be expressed in many types of cancer cells, including breast, lung, and ovarian cancer cells. Additionally, KRBA2 has been shown to be overexpressed in many types of cancer, which suggests that it may be a useful biomarker for the diagnosis and evaluation of cancer.
In conclusion, KRBA2 is a unique protein that has been shown to play a role in cell signaling pathways and has potential as a drug target and biomarker. Further research is needed to fully understand the functions of KRBA2 and its potential as a drug.
Protein Name: KRAB-A Domain Containing 2
The "KRBA2 Target / Biomarker Review Report" is a customizable review of hundreds up to thousends of related scientific research literature by AI technology, covering specific information about KRBA2 comprehensively, including but not limited to:
• general information;
• protein structure and compound binding;
• protein biological mechanisms;
• its importance;
• the target screening and validation;
• expression level;
• disease relevance;
• drug resistance;
• related combination drugs;
• pharmacochemistry experiments;
• related patent analysis;
• advantages and risks of development, etc.
The report is helpful for project application, drug molecule design, research progress updates, publication of research papers, patent applications, etc. If you are interested to get a full version of this report, please feel free to contact us at BD@silexon.ai
More Common Targets
KRBOX1 | KRBOX1-AS1 | KRBOX4 | KRBOX5 | KRCC1 | KREMEN1 | KREMEN2 | KRI1 | KRIT1 | KRR1 | KRT1 | KRT10 | KRT10-AS1 | KRT12 | KRT126P | KRT13 | KRT14 | KRT15 | KRT16 | KRT16P1 | KRT16P2 | KRT16P3 | KRT16P6 | KRT17 | KRT17P1 | KRT17P2 | KRT17P3 | KRT17P5 | KRT17P7 | KRT18 | KRT18P1 | KRT18P12 | KRT18P13 | KRT18P16 | KRT18P17 | KRT18P19 | KRT18P22 | KRT18P23 | KRT18P24 | KRT18P27 | KRT18P28 | KRT18P29 | KRT18P31 | KRT18P33 | KRT18P34 | KRT18P4 | KRT18P40 | KRT18P41 | KRT18P42 | KRT18P44 | KRT18P48 | KRT18P49 | KRT18P5 | KRT18P50 | KRT18P51 | KRT18P55 | KRT18P59 | KRT18P6 | KRT18P62 | KRT19 | KRT19P2 | KRT19P3 | KRT2 | KRT20 | KRT222 | KRT23 | KRT24 | KRT25 | KRT26 | KRT27 | KRT28 | KRT3 | KRT31 | KRT32 | KRT33A | KRT33B | KRT34 | KRT35 | KRT36 | KRT37 | KRT38 | KRT39 | KRT4 | KRT40 | KRT42P | KRT5 | KRT6A | KRT6B | KRT6C | KRT7 | KRT7-AS | KRT71 | KRT72 | KRT73 | KRT73-AS1 | KRT74 | KRT75 | KRT76 | KRT77 | KRT78
