KLK12: A Protein Involved in Proteolytic Enzyme Regulation and Cellular Signaling

Target Name: KLK12

NCBI ID: G43849

KLK12

KLK12: A Protein Involved in Proteolytic Enzyme Regulation and Cellular Signaling

KLK12 (Kallikrein-Related Peptidase 12) is a protein that is expressed in a variety of tissues throughout the body, including the skin, bone, and connective tissue. It is a 12-kDa protein that belongs to the serine proteases, or enzymes, family 11. This protein plays a role in the regulation of proteolytic enzymes, which are enzymes that break down other proteins.

KLK12 is characterized by its unique structure and sequence. It has a molecular weight of 114 kDa and a calculated pI of 6.4. KLK12 is a monomer with one active site, which is located at its N-terminus. The active site is characterized by a positively charged residue (E) and a negatively charged residue (D) at its C-terminus.

KLK12 is involved in a variety of physiological processes in the body, including cell signaling, tissue repair, and inflammation. One of its most well-known functions is in the regulation of the proteolytic enzyme, Kallikrein-Catalyzed Acylation (KCAT), which is involved in the production of collagen and other extracellular matrix (ECM) components.

KCAT is a potent enzyme that generates a highly reactive carbonyl group (-COOH) on the amino acid lysine residue of the substrate. This carbonyl group can then react with other amino acids to form a covalent bond, resulting in the formation of a new amino acid derivative. The production of carbonyl groups by KCAT is critical for the regulation of extracellular matrix growth and turnover, as well as tissue repair and regeneration.

KLK12 has also been shown to play a role in the regulation of other proteases, including the proteases that are involved in inflammation and pain signaling. For example, KLK12 has been shown to regulate the activity of the protease, heat-induced trypsin (HIT), which is involved in the production of pro-inflammatory cytokines.

In addition to its role in the regulation of proteases, KLK12 has also been shown to play a role in the regulation of cell signaling pathways. For example, KLK12 has been shown to interact with the protein, heat-induced reactive oxygen species (ROS) homeostasis regulator (HIR), which is involved in the regulation of cellular stress responses.

KLK12 is also a potential drug target for several diseases. For example, KLK12 has been shown to be involved in the development and progression of certain types of cancer, including breast and colorectal cancer. Additionally, KLK12 has been shown to be involved in the regulation of the immune response, which could make it a potential target for diseases that are characterized by inflammation and autoimmune responses.

In conclusion, KLK12 is a protein that plays a critical role in the regulation of proteolytic enzymes and other cellular processes. Its unique structure and sequence, as well as its involvement in several important physiological processes, make it an attractive target for research and clinical development. Further research is needed to fully understand the role of KLK12 in the regulation of cellular processes and its potential as a drug target.

Protein Name: Kallikrein Related Peptidase 12

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•   general information;
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•   expression level;
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