DERA's Role in Obesity and Diabetes (G51071)

Target Name: DERA

NCBI ID: G51071

DERA

DERA's Role in Obesity and Diabetes

Deoxyribose-phosphate aldolase (ISO form 1), also known as DERA, is a protein that plays a crucial role in the metabolism of obesity and diabetes. It is an enzyme that is responsible for breaking down a type of sugar called fructose, which is found in fruit and some sweeteners.

The study of DERA and its potential as a drug target or biomarker has gained significant attention in recent years. Researchers have identified that high levels of DERA activity are associated with an increased risk of obesity and type 2 diabetes. Additionally, individuals with certain genetic variations in the DERA gene have an increased likelihood of developing these conditions.

One of the key ways that DERA is linked to obesity and diabetes is its role in the metabolism of fructose. Fructose is a type of sugar that is found in fruit and some sweeteners, and it is difficult for the body to process. When fructose is consumed, it is broken down into its component parts, including glucose and fructose 6-phosphate. DERA is responsible for breaking down fructose 6-phosphate into glucose and fructose 1,6-beta-diol.

Research has shown that individuals with certain genetic variations in the DERA gene have an increased likelihood of developing obesity and type 2 diabetes. This is because these individuals have a reduced ability to break down fructose, which can lead to high levels of fructose in the body.

Another way that DERA is linked to obesity and diabetes is its role in the metabolism of glucose. Glucose is the primary source of energy for the body, and it is important for maintaining proper brain function and keeping blood sugar levels in check. DERA is involved in the breakdown of glucose, and research has shown that individuals with certain genetic variations in the DERA gene have an increased likelihood of developing type 2 diabetes.

In addition to its role in the metabolism of fructose and glucose, DERA is also involved in the regulation of inflammation in the body. Inflammation is a natural response of the immune system, but when it becomes chronic or out of control, it can lead to a variety of health problems, including obesity and type 2 diabetes.

Research has shown that individuals with certain genetic variations in the DERA gene are also more likely to have chronic inflammation in the body. This is because DERA plays a role in the regulation of the immune response and the production of pro-inflammatory molecules.

Overall, the study of DERA and its potential as a drug target or biomarker is an exciting area of 鈥嬧?媟esearch with significant implications for the treatment of obesity and type 2 diabetes. Further studies are needed to fully understand the role of DERA in these conditions and to develop effective treatments.

Protein Name: Deoxyribose-phosphate Aldolase

Functions: Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy-D-ribose 5-phosphate. Participates in stress granule (SG) assembly. May allow ATP production from extracellular deoxyinosine in conditions of energy deprivation

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