DEPTOR: A Potential Drug Target and Biomarker for mTORC1 Signaling

Target Name: DEPTOR

NCBI ID: G64798

DEPTOR

DEPTOR: A Potential Drug Target and Biomarker for mTORC1 Signaling

Introduction

Theme: mTOR (mechanistic target of rapamycin) is a key regulator of cell growth, metabolism, and survival, and its dysregulation has been implicated in numerous diseases, including cancer, neurodegenerative diseases, and metabolic disorders. The DEPTOR protein, a DEP domain- containing mTOR-interacting protein, has been identified as a potential drug target and biomarker for mTORC1 signaling. This article will summarize the DEPTOR protein, its functions, potential drug targets, and its potential as a biomarker for disease.

Overview of DEPTOR

DEPTOR is a 21 kDa protein that belongs to the mTORC1 signaling pathway. It consists of a 21 kDa protein and a 4 kDa N-terminal domain (N-tail). The N-tail contains a putative N-terminal domain-protein interaction domain (ND domain) and a 64 amino acid residue-rich region (R64) that is involved in protein-protein interactions.

DEPTOR functions as a critical component of the mTORC1 signaling pathway. It interacts with the mTOR complex, which consists of the 26 kDa protein complex 1 (p700) and the 28 kDa protein complex 2 (p701), and is involved in regulating cellular processes such as cell growth, metabolism, and survival.

Potential Drug Targets

DEPTOR has been identified as a potential drug target for mTORC1 signaling due to its critical role in regulating cellular processes that are affected by mTORC1 dysregulation. Several studies have suggested that DEPTOR can be a drug target for cancer, neurodegenerative diseases, and metabolic disorders.

1.Cancer

DEPTOR has been shown to be involved in the regulation of cell cycle progression, apoptosis, and angiogenesis, which are processes that are critical for cancer development. Several studies have shown that DEPTOR can be inhibited by small molecules, such as rapamycin and its analogues, leading to the inhibition of mTORC1 signaling and the inhibition of cellular processes that are critical for cancer development. Therefore, DEPTOR may be a useful drug target for cancer treatment.

2. Neurodegenerative Diseases

DEPTOR has been shown to be involved in the regulation of cellular processes that are critical for the development and progression of neurodegenerative diseases. The mTORC1 signaling pathway has been shown to play a role in the regulation of neurodegenerative diseases, and DEPTOR has been shown to be involved in this regulation. Therefore, DEPTOR may be a potential drug target for neurodegenerative diseases.

3. Metabolic Disorders

DEPTOR has been shown to be involved in the regulation of cellular processes that are critical for the development and progression of metabolic disorders. The mTORC1 signaling pathway has been shown to play a role in the regulation of metabolic disorders, and DEPTOR has been shown to be involved in this regulation. Therefore, DEPTOR may be a potential drug target for metabolic disorders.

Potential Biomarkers

DEPTOR has been shown to be involved in the regulation of cellular processes that are critical for the development and progression of diseases. Therefore, it may be a potential biomarker for disease. Several studies have shown that the levels of DEPTOR are regulated in diseases, such as cancer, neurodegenerative diseases, and metabolic disorders. Therefore, DEPTOR may be a potential biomarker for disease.

Conclusion

In conclusion, DEPTOR is a protein that is involved in the regulation of cellular processes that are critical for the development and progression of diseases. Its functions include the regulation of cell growth, metabolism, and survival, and it has been shown to be a potential drug target for cancer, neurodegenerative diseases, and metabolic disorders. Its potential as a biomarker for disease has also been shown. Further research is needed to fully understand the functions and potential of DEPTOR as a drug target and biomarker for disease.

Protein Name: DEP Domain Containing MTOR Interacting Protein

Functions: Negative regulator of the mTORC1 and mTORC2 signaling pathways. Inhibits the kinase activity of both complexes

The "DEPTOR Target / Biomarker Review Report" is a customizable review of hundreds up to thousends of related scientific research literature by AI technology, covering specific information about DEPTOR comprehensively, including but not limited to:
•   general information;
•   protein structure and compound binding;
•   protein biological mechanisms;
•   its importance;
•   the target screening and validation;
•   expression level;
•   disease relevance;
•   drug resistance;
•   related combination drugs;
•   pharmacochemistry experiments;
•   related patent analysis;
•   advantages and risks of development, etc.
The report is helpful for project application, drug molecule design, research progress updates, publication of research papers, patent applications, etc. If you are interested to get a full version of this report, please feel free to contact us at BD@silexon.ai

More Common Targets