NFE2: A Potential Drug Target and Biomarker (G4778)

Target Name: NFE2

NCBI ID: G4778

NFE2

NFE2: A Potential Drug Target and Biomarker

Nuclear factor of activating transcription factor (NF-E2) is a key transcription factor that regulates gene expression and plays a crucial role in the development and maintenance of tissues. NF-E2 is a protein that consists of two subunits, the 45 kDa subunit (ISOFORM 1) and the 26 kDa subunit (ISOFORM 2). The 45 kDa subunit is the most well-studied subunit, and its function in cell biology has been extensively investigated. In this article, we will discuss the 45 kDa subunit of NF-E2 (NFE2), its function, potential drug targets, and use as a biomarker.

Function of NFE2

The 45 kDa subunit of NF-E2 is a key transcription factor that regulates gene expression by binding to specific DNA sequences. NFE2 plays a crucial role in the regulation of cell growth, differentiation, and apoptosis. It is known to regulate the expression of genes involved in cell adhesion, migration, and invasion, as well as in the regulation of cell cycle progression.

NFE2 has been shown to play a role in the regulation of various cellular processes, including cell growth, apoptosis, and cell cycle progression. For example, studies have shown that NFE2 can promote the growth and survival of cancer cells, and that it is involved in the regulation of cell cycle progression in these cells. NFE2 has also been shown to play a role in the regulation of cell adhesion and migration, as well as in the regulation of ion channels and neurotransmitter signaling.

Potential Drug Targets

NFE2 is a protein that has potential as a drug target due to its involvement in various cellular processes that are important for human health and disease. One potential drug target for NFE2 is the regulation of cell growth and apoptosis. NFE2 has been shown to promote the growth and survival of cancer cells, and it is possible that inhibiting NFE2 activity could be a effective way to treat cancer.

Another potential drug target for NFE2 is the regulation of cell cycle progression. NFE2 has been shown to play a role in the regulation of cell cycle progression, and it is possible that inhibiting NFE2 activity could be a way to treat certain forms of cancer.

NFE2 has also been shown to play a role in the regulation of cell adhesion and migration. NFE2 has been shown to interact with various cell adhesion molecules, including cadherin and E-cadherin. In addition, NFE2 has been shown to play a role in the regulation of neurotransmitter signaling, which is important for various cellular processes, including mood regulation and learning.

Biomarker

NFE2 is also a potential biomarker for certain diseases. For example, NFE2 has been shown to be overexpressed in various diseases, including cancer, neurodegenerative diseases, and autoimmune diseases. In addition, NFE2 has been shown to be involved in the regulation of cellular processes that are involved in disease development, such as cell growth, apoptosis, and cell cycle progression.

Conclusion

In conclusion, the 45 kDa subunit of NF-E2 (NFE2) is a protein that plays a crucial role in the regulation of various cellular processes that are important for human health and disease. NFE2 is a potential drug target due to its involvement in the regulation of cell growth, apoptosis, cell cycle progression, and cell adhesion and migration. NFE2 is also a potential biomarker for certain diseases. Further research is needed to fully understand the functions of NFE2 and its potential as a drug target and biomarker.

Protein Name: Nuclear Factor, Erythroid 2

Functions: Component of the NF-E2 complex essential for regulating erythroid and megakaryocytic maturation and differentiation. Binds to the hypersensitive site 2 (HS2) of the beta-globin control region (LCR). This subunit (NFE2) recognizes the TCAT/C sequence of the AP-1-like core palindrome present in a number of erythroid and megakaryocytic gene promoters. Requires MAFK or other small MAF proteins for binding to the NF-E2 motif. May play a role in all aspects of hemoglobin production from globin and heme synthesis to procurement of iron

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•   expression level;
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The report is helpful for project application, drug molecule design, research progress updates, publication of research papers, patent applications, etc. If you are interested to get a full version of this report, please feel free to contact us at BD@silexon.ai

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