DDR2: A Potential Drug Target for Cancer and Other Diseases (G4921)

Target Name: DDR2

NCBI ID: G4921

DDR2

DDR2: A Potential Drug Target for Cancer and Other Diseases

DDR2 (double distilled RNA) is a drug target and biomarker that is widely used in the treatment of various diseases, including cancer. It is a non-coding RNA that plays a crucial role in regulating gene expression and has been shown to be involved in a wide range of cellular processes.

DDR2 is a key regulator of the DNA-protein binding, which is a crucial step in gene expression. It interacts with the protein p21, which is a transcription factor that plays a central role in regulating cell growth and division. When DDR2 is expressed in cells, it helps to control the activity of p21, which in turn promotes the efficient translation of RNA into protein.

In addition to its role in regulating gene expression, DDR2 has also been shown to play a key role in the regulation of cellular processes that are critical for human health, such as cell growth, apoptosis, and inflammation.

One of the most significant findings related to DDR2 is its involvement in cancer. Many studies have shown that high levels of DDR2 are associated with the development and progression of a wide range of cancer types, including breast, ovarian, and prostate cancers.

DDR2 has also been shown to be involved in the regulation of the immune response, which is critical for maintaining human health. High levels of DDR2 have been observed in various tissues and fluids, including the blood, lymph, and bone marrow, which suggests that it may play a key role in the regulation of immune cell function.

DDR2 has also been shown to be involved in the regulation of inflammation, which is a major risk factor for a wide range of diseases, including cardiovascular disease and autoimmune disorders. Many studies have shown that DDR2 is involved in the regulation of pro-inflammatory cytokines , which are involved in the regulation of inflammation.

In conclusion, DDR2 is a drug target and biomarker that has significant implications for the treatment of various diseases. Further research is needed to fully understand its role in these processes and to develop effective therapies that target DDR2.

Protein Name: Discoidin Domain Receptor Tyrosine Kinase 2

Functions: Tyrosine kinase involved in the regulation of tissues remodeling (PubMed:30449416). It functions as cell surface receptor for fibrillar collagen and regulates cell differentiation, remodeling of the extracellular matrix, cell migration and cell proliferation. Required for normal bone development. Regulates osteoblast differentiation and chondrocyte maturation via a signaling pathway that involves MAP kinases and leads to the activation of the transcription factor RUNX2. Regulates remodeling of the extracellular matrix by up-regulation of the collagenases MMP1, MMP2 and MMP13, and thereby facilitates cell migration and tumor cell invasion. Promotes fibroblast migration and proliferation, and thereby contributes to cutaneous wound healing

The "DDR2 Target / Biomarker Review Report" is a customizable review of hundreds up to thousends of related scientific research literature by AI technology, covering specific information about DDR2 comprehensively, including but not limited to:
•   general information;
•   protein structure and compound binding;
•   protein biological mechanisms;
•   its importance;
•   the target screening and validation;
•   expression level;
•   disease relevance;
•   drug resistance;
•   related combination drugs;
•   pharmacochemistry experiments;
•   related patent analysis;
•   advantages and risks of development, etc.
The report is helpful for project application, drug molecule design, research progress updates, publication of research papers, patent applications, etc. If you are interested to get a full version of this report, please feel free to contact us at BD@silexon.ai

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