UCHL5: A Potential Drug Target and Biomarker (G51377)

Target Name: UCHL5

NCBI ID: G51377

UCHL5

UCHL5: A Potential Drug Target and Biomarker

Ubiquitin (U) is a protein that plays a crucial role in the regulation of protein-protein interactions, DNA repair, and cell signaling pathways. UCHL5, a member of the U-type ubiquitin hydrolase family, is an enzyme that adds a ubiquitin tag to specific lysine residues on target proteins. The UCHL5 gene has four splice variants, including transcript variant 1 (UCHL5-T1), which has been extensively studied. In this article, we will discuss the potential implications of UCHL5 as a drug target and biomarker.

The UCHL5 enzyme is involved in a wide range of cellular processes, including cell signaling, DNA repair, and inflammation. UCHL5 is a key player in the ubiquitin system, as it adds a ubiquitin tag to specific lysine residues on target proteins. This modification plays a crucial role in the regulation of protein-protein interactions and in the assembly of various cellular signaling pathways.

UCHL5 has been shown to be involved in various cellular processes, including cell signaling, cell division, and DNA repair. For example, UCHL5 has been shown to be involved in the regulation of cell proliferation and has been shown to play a role in the G1/S transition, which is a critical step in the cell cycle.

In addition to its role in cell signaling and cell division, UCHL5 is also involved in DNA repair. DNA repair is a critical process that ensures the stability of genetic information and protects against genetic mutations. UCHL5 is involved in the repair of various types of DNA damage, including double-strand breaks and single-strand breaks.

In conclusion, UCHL5 is a protein that plays a crucial role in the regulation of protein-protein interactions, DNA repair, and cell signaling pathways. The potential implications of UCHL5 as a drug target and biomarker are vast and continue to be explored by researchers. Further research is needed to fully understand the role of UCHL5 in cellular processes and its potential as a drug target.

Protein Name: Ubiquitin C-terminal Hydrolase L5

Functions: Protease that specifically cleaves 'Lys-48'-linked polyubiquitin chains. Deubiquitinating enzyme associated with the 19S regulatory subunit of the 26S proteasome. Putative regulatory component of the INO80 complex; however is inactive in the INO80 complex and is activated by a transient interaction of the INO80 complex with the proteasome via ADRM1

The "UCHL5 Target / Biomarker Review Report" is a customizable review of hundreds up to thousends of related scientific research literature by AI technology, covering specific information about UCHL5 comprehensively, including but not limited to:
•   general information;
•   protein structure and compound binding;
•   protein biological mechanisms;
•   its importance;
•   the target screening and validation;
•   expression level;
•   disease relevance;
•   drug resistance;
•   related combination drugs;
•   pharmacochemistry experiments;
•   related patent analysis;
•   advantages and risks of development, etc.
The report is helpful for project application, drug molecule design, research progress updates, publication of research papers, patent applications, etc. If you are interested to get a full version of this report, please feel free to contact us at BD@silexon.ai

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