Target Name: GTSE1
NCBI ID: G51512
Review Report on GTSE1 Target / Biomarker Content of Review Report on GTSE1 Target / Biomarker
GTSE1
Other Name(s): GTSE-1 | G2 and S-phase expressed 1 | Protein B99 homolog | protein B99 homolog | B99 | G2 and S phase-expressed protein 1 | GTSE1_HUMAN | B99 homolog | Lnc_bc060912 | G-2 and S-phase expressed 1 | OTTHUMP00000028851

Discovering The Potential Role of GTSE-1 in Drug Targets

Guanosine Triphosphate-1 (GTSE-1) is a protein that exists in a variety of cells and tissues. Its function is to catalyze phosphorylation reactions. GTSE-1 plays an important role in biological processes such as cell signaling, metabolic regulation, cell proliferation and apoptosis. In recent years, researchers have conducted in-depth studies on the biological functions of GTSE-1 and also discovered the potential role of GTSE-1 in drug targets. This article will discuss the biological functions and drug targets of GTSE-1.

Biological functions of GTSE-1
GTSE-1 is a transduction enzyme that participates in multiple signaling pathways within cells. In the GTP (guanosine triphosphate) signaling pathway, GTSE-1 catalyzes the binding of GTP to intracellular receptor proteins, thereby triggering a series of signaling reactions. In addition, GTSE-1 is also involved in biological processes such as cell proliferation and apoptosis, regulating cell cycle, cell growth and cell death.

During tumor occurrence and development, the expression level of GTSE-1 changes. Studies have found that the expression level of GTSE-1 is positively correlated with various tumor types (such as lung cancer, liver cancer, breast cancer, etc.). In addition, the expression level of GTSE-1 is also closely related to the invasion and metastasis ability of tumors. Therefore, by regulating the biological functions of GTSE-1, we can effectively intervene in tumor occurrence and development.

Drug Targets of GTSE-1 Because GTSE-1 has important functions in biological processes, it is widely used in drug development. At present, drug research on GTSE-1 mainly focuses on the following aspects:

1. GTSE-1 inhibitors

Inhibitors are a class of molecules that inhibit the biological activity of GTSE-1. By inhibiting the function of GTSE-1, the rate of intracellular signal transduction can be reduced, thereby achieving the purpose of treating tumors. At present, inhibitors targeting GTSE-1 mainly include organic small molecule compounds, macromolecule inhibitors and drug coupling agents.

2. GTSE-1 agonists

Agonists are a class of molecules that enhance the biological activity of GTSE-1. By stimulating the function of GTSE-1, the rate of intracellular signaling can be promoted, thereby activating a series of biological processes. At present, agonists targeting GTSE-1 mainly include organic small molecule compounds, macromolecular agonists and drug coupling agents.

3. GTSE-1 antagonist

Antagonists are a class of molecules that block the binding of GTSE-1 to GTP. By blocking the binding of GTSE-1 to GTP, the rate of intracellular signaling can be reduced, thereby inhibiting the growth and spread of tumor cells. At present, antagonists against GTSE-1 mainly include organic small molecule compounds and drug coupling agents.

4. Gene therapy of GTSE-1

Gene therapy is a method of treating tumors by introducing exogenous genes into target cells through genetic engineering technology. Gene therapy for GTSE-1 mainly includes the following aspects:

(1) Gene editing technology: Through gene editing technology, gene fragments with therapeutic effects are introduced into target cells to achieve the inhibitory effect on GTSE-1.

(2) Gene targeting technology: Through gene targeting technology, gene fragments with therapeutic effects are combined with tumor cell-specific receptors to achieve antagonism against GTSE-1.

(3) Gene combination therapy: By combining gene fragments with therapeutic effects with molecules such as tumor cell-specific receptors and drug coupling agents, the inhibitory effect on GTSE-1 can be achieved.

in conclusion
GTSE-1 has important functions in biological processes and is an important target for drug development. At present, drug research on GTSE-1 mainly includes inhibitors, agonists, antagonists and gene therapy. However, drug research targeting GTSE-1 is still in its preliminary stages, and further in-depth research on the biological functions and drug targets of GTSE-1 is needed to provide more effective drugs for clinical treatment.

Protein Name: G2 And S-phase Expressed 1

Functions: May be involved in p53-induced cell cycle arrest in G2/M phase by interfering with microtubule rearrangements that are required to enter mitosis. Overexpression delays G2/M phase progression

The "GTSE1 Target / Biomarker Review Report" is a customizable review of hundreds up to thousends of related scientific research literature by AI technology, covering specific information about GTSE1 comprehensively, including but not limited to:
•   general information;
•   protein structure and compound binding;
•   protein biological mechanisms;
•   its importance;
•   the target screening and validation;
•   expression level;
•   disease relevance;
•   drug resistance;
•   related combination drugs;
•   pharmacochemistry experiments;
•   related patent analysis;
•   advantages and risks of development, etc.
The report is helpful for project application, drug molecule design, research progress updates, publication of research papers, patent applications, etc. If you are interested to get a full version of this report, please feel free to contact us at BD@silexon.ai

More Common Targets

GTSE1-DT | GTSF1 | GTSF1L | Guanine nucleotide-binding protein G(t) complex | Guanylate cyclase | Guanylate kinase (isoform b) | GUCA1A | GUCA1B | GUCA1C | GUCA2A | GUCA2B | GUCD1 | GUCY1A1 | GUCY1A2 | GUCY1B1 | GUCY1B2 | GUCY2C | GUCY2D | GUCY2EP | GUCY2F | GUCY2GP | GUF1 | GUK1 | GULOP | GULP1 | GUSB | GUSBP1 | GUSBP11 | GUSBP12 | GUSBP14 | GUSBP15 | GUSBP17 | GUSBP2 | GUSBP3 | GUSBP4 | GUSBP5 | GUSBP8 | GVINP1 | GVQW3 | GXYLT1 | GXYLT1P3 | GXYLT1P4 | GXYLT1P6 | GXYLT2 | GYG1 | GYG2 | GYPA | GYPB | GYPC | GYPE | GYS1 | GYS2 | GZF1 | GZMA | GZMB | GZMH | GZMK | GZMM | H1-0 | H1-1 | H1-10 | H1-10-AS1 | H1-2 | H1-3 | H1-4 | H1-5 | H1-6 | H1-7 | H1-8 | H1-9P | H19 | H19-ICR | H2AB1 | H2AB2 | H2AB3 | H2AC1 | H2AC11 | H2AC12 | H2AC13 | H2AC14 | H2AC15 | H2AC16 | H2AC17 | H2AC18 | H2AC20 | H2AC21 | H2AC25 | H2AC3P | H2AC4 | H2AC6 | H2AC7 | H2AJ | H2AP | H2AX | H2AZ1 | H2AZ1-DT | H2AZ2 | H2AZ2-DT | H2AZP2 | H2BC1