Inhibitors of MPC1: Potential Therapeutic Benefits (G51660)

Target Name: MPC1

NCBI ID: G51660

MPC1

Inhibitors of MPC1: Potential Therapeutic Benefits

Mitochondrial Pyruvate Carrier 1 (MPC1), also known as ISOform 1, is a protein that plays a crucial role in the metabolism of pyruvate, a critical fuel for the cell's energy-producing process. MPC1 is encoded by the MPC1 gene and is expressed in the mitochondria, where it functions as a transporter for pyruvate across the inner mitochondrial membrane.

MPC1 is a 12-kDa protein that consists of two distinct subunits, alpha and beta subunits. The alpha subunit is responsible for the overall transport of pyruvate across the membrane, while the beta subunit is involved in the specific localization of pyruvate to the inner mitochondrial membrane.

MPC1 function is crucial for the proper functioning of the mitochondria, as the organ is responsible for generating the majority of the cell's energy through the citric acid cycle. The ability of pyruvate to cross the membrane and be utilized as a fuel for this process is essential for maintaining cellular energy homeostasis.

MPC1 has been implicated in a number of cellular processes, including the regulation of cellular energy metabolism, cell signaling, and stress resistance. Studies have shown that changes in MPC1 levels or function can have a significant impact on cellular behavior and physiology.

Due to its involvement in so many cellular processes, MPC1 has naturally emerged as a potential drug target or biomarker. Studies have suggested that inhibiting MPC1 function may have therapeutic benefits for a variety of diseases, including cancer, neurodegenerative diseases, and metabolism disorders.

One approach to inhibiting MPC1 function is through the use of small molecules, such as drugs that bind to specific regions of the MPC1 protein. These molecules can either inhibit the activity of MPC1 or alter its structure to make it less functional. One such class of Drugs are called inhibitors of the electron transport chain, which is a complex of proteins that facilitate the flow of electrons through the mitochondrial membrane.

In recent years, several inhibitors of the electron transport chain have been shown to have potential therapeutic benefits. For example, studies have shown that inhibitors of the

Protein Name: Mitochondrial Pyruvate Carrier 1

Functions: Mediates the uptake of pyruvate into mitochondria

The "MPC1 Target / Biomarker Review Report" is a customizable review of hundreds up to thousends of related scientific research literature by AI technology, covering specific information about MPC1 comprehensively, including but not limited to:
•   general information;
•   protein structure and compound binding;
•   protein biological mechanisms;
•   its importance;
•   the target screening and validation;
•   expression level;
•   disease relevance;
•   drug resistance;
•   related combination drugs;
•   pharmacochemistry experiments;
•   related patent analysis;
•   advantages and risks of development, etc.
The report is helpful for project application, drug molecule design, research progress updates, publication of research papers, patent applications, etc. If you are interested to get a full version of this report, please feel free to contact us at BD@silexon.ai

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