PARP14: A Drug Target / Disease Biomarker (G54625)

Target Name: PARP14

NCBI ID: G54625

PARP14

PARP14: A Drug Target / Disease Biomarker

PARP-14 is a protein that is expressed in various tissues throughout the body, including the brain, spleen, heart, and testes. It is a key regulator of the DNA damage response, which is a critical process that helps the body repair itself when it experiences damage to its DNA.

PARP-14 plays a crucial role in ensuring that the DNA damage response is efficient and effective. When DNA is damaged, PARP-14 helps to ensure that the repair process is initiated and carried out correctly. This is important because if the DNA damage response is not efficient or is not carried out effectively, it can lead to the development of cancer.

One of the key functions of PARP-14 is its role in DNA repair. When DNA is damaged, PARP-14 helps to ensure that the repair process is initiated and carried out correctly. This is important because if the DNA damage response is not efficient or is not carried out effectively, it can lead to the development of cancer.

Another important function of PARP-14 is its role in cell signaling. PARP-14 is a key regulator of the DNA damage response, and it is involved in the signaling process that regulates the cell's response to DNA damage. This is important because if the DNA damage response is not properly regulated, it can lead to the development of cancer.

In addition to its role in DNA repair and cell signaling, PARP-14 is also involved in the regulation of inflammation. When the body experiences damage to its tissues, PARP-14 helps to regulate the immune response and ensure that inflammation is not triggered. This is important because if inflammation is not properly regulated, it can lead to the development of cancer.

Overall, PARP-14 is a protein that is critical for ensuring the efficiency and effectiveness of the body's DNA damage response. Its role in DNA repair, cell signaling, and inflammation makes it an attractive drug target for researchers.

PARP-14 is a protein that is expressed in various tissues throughout the body, including the brain, spleen, heart, and testes. It is a key regulator of the DNA damage response, which is a critical process that helps the body repair itself when it experiences damage to its DNA.

PARP-14 plays a crucial role in ensuring that the DNA damage response is efficient and effective. When DNA is damaged, PARP-14 helps to ensure that the repair process is initiated and carried out correctly. This is important because if the DNA damage response is not efficient or is not carried out effectively, it can lead to the development of cancer.

One of the key functions of PARP-14 is its role in DNA repair. When DNA is damaged, PARP-14 helps to ensure that the repair process is initiated and carried out correctly. This is important because if the DNA damage response is not efficient or is not carried out effectively, it can lead to the development of cancer.

Another important function of PARP-14 is its role in cell signaling. PARP-14 is a key regulator of the DNA damage response, and it is involved in the signaling process that regulates the cell's response to DNA damage. This is important because if the DNA damage response is not properly regulated, it can lead to the development of cancer.

In addition to its role in DNA repair and cell signaling, PARP-14 is also involved in the regulation of inflammation. When the body experiences damage to its tissues, PARP-14 helps to regulate the immune response and ensure that inflammation is not triggered. This is important because if inflammation is not properly regulated, it can lead to the development of cancer.

Overall, PARP-14 is a protein that is critical for ensuring the efficiency and effectiveness of the body's DNA damage response. Its role in DNA repair, cell signaling, and inflammation makes it an attractive drug target for researchers.

Protein Name: Poly(ADP-ribose) Polymerase Family Member 14

Functions: ADP-ribosyltransferase that mediates mono-ADP-ribosylation of glutamate residues on target proteins (PubMed:16061477, PubMed:27796300, PubMed:18851833, PubMed:25043379). In contrast to PARP1 and PARP2, it is not able to mediate poly-ADP-ribosylation (PubMed:25043379). Has been shown to catalyze the mono-ADP-ribosylation of STAT1 at 'Glu-657' and 'Glu-705', thus decreasing STAT1 phosphorylation which negatively regulates pro-inflammatory cytokine production in macrophages in response to IFNG stimulation (PubMed:27796300). However, the role of ADP-ribosylation in the prevention of STAT1 phosphorylation has been called into question and it has been suggested that the inhibition of phosphorylation may be the result of sumoylation of STAT1 'Lys-703' (PubMed:29858569). Mono-ADP-ribosylates STAT6; enhancing STAT6-dependent transcription (PubMed:27796300). In macrophages, positively regulates MRC1 expression in response to IL4 stimulation by promoting STAT6 phosphorylation (PubMed:27796300). Mono-ADP-ribosylates PARP9 (PubMed:27796300)

The "PARP14 Target / Biomarker Review Report" is a customizable review of hundreds up to thousends of related scientific research literature by AI technology, covering specific information about PARP14 comprehensively, including but not limited to:
•   general information;
•   protein structure and compound binding;
•   protein biological mechanisms;
•   its importance;
•   the target screening and validation;
•   expression level;
•   disease relevance;
•   drug resistance;
•   related combination drugs;
•   pharmacochemistry experiments;
•   related patent analysis;
•   advantages and risks of development, etc.
The report is helpful for project application, drug molecule design, research progress updates, publication of research papers, patent applications, etc. If you are interested to get a full version of this report, please feel free to contact us at BD@silexon.ai

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