MKS1: A Potential Drug Target and Biomarker for Diseases (G54903)
MKS1: A Potential Drug Target and Biomarker for Diseases
MKS1 (Meckel syndrome type 1 protein) is a protein that is expressed in most tissues of the body, including the brain, heart, and pancreas. It is a member of the heat shock protein (HSP) family and is involved in various cellular processes that are essential for cell survival. MKS1 has also been identified as a potential drug target and biomarker for several diseases, including cancer, neurodegenerative diseases, and autoimmune disorders.
MKS1 functions as a protein that can interact with various cellular components, including DNA, RNA, and proteins. Its functions include the regulation of gene expression, DNA replication, and the detoxification of harmful substances. MKS1 is also involved in the regulation of cell adhesion, which is critical for the development and maintenance of tissues and organs.
One of the most significant functions of MKS1 is its role in the regulation of cell cycle progression. MKS1 is involved in the regulation of the G1/S transition, which is the stage of cell growth where the cell prepares for cell division. During the G1/S transition, MKS1 helps to ensure that the cell enters into the S phase of the cell cycle, where DNA replication and gene expression can occur. This is important for the development and growth of tissues and organs, and is a critical step in the regulation of cell growth and division.
MKS1 is also involved in the regulation of DNA replication, which is the process by which a cell makes a copy of its DNA. During DNA replication, MKS1 helps to ensure that the replicated DNA is accurately copied and that any errors or mutations are detected and corrected. This is important for the integrity of the cell's genetic material and is a critical step in the regulation of cell growth and development.
In addition to its role in cell cycle regulation, MKS1 is also involved in the detoxification of harmful substances. Many toxins and harmful substances can harm the body and cause a range of diseases, including cancer, neurodegenerative diseases, and autoimmune disorders. MKS1 is involved in the detoxification of these harmful substances, which is critical for the maintenance of cellular health and the prevention of diseases.
MKS1 has also been identified as a potential drug target and biomarker for several diseases. For example, MKS1 has been shown to be overexpressed in various neurodegenerative diseases, including Alzheimer's disease, Parkinson's disease, and Huntington's disease. This suggests that MKS1 may be a useful target for these diseases and could potentially be used as a drug or diagnostic biomarker.
MKS1 has also been shown to be involved in the regulation of various signaling pathways, including the TGF-β pathway. This pathway is involved in the regulation of cell growth, differentiation, and survival, and is a critical factor in the development and maintenance of tissues and organs. MKS1 is involved in the regulation of TGF-β signaling, which is important for the development and maintenance of tissues and organs and may be a potential target for drugs that are used to treat these diseases.
In conclusion, MKS1 is a protein that is involved in various cellular processes that are essential for cell survival. It is a member of the HSP family and is involved in the regulation of cell cycle progression, DNA replication, and detoxification. MKS1 has also been identified as a potential drug target and biomarker for several diseases, including cancer, neurodegenerative diseases, and autoimmune disorders. Further research is needed to fully understand the functions of MKS1 and its potential as a drug target and biomarker.
Protein Name: MKS Transition Zone Complex Subunit 1
Functions: Component of the tectonic-like complex, a complex localized at the transition zone of primary cilia and acting as a barrier that prevents diffusion of transmembrane proteins between the cilia and plasma membranes. Involved in centrosome migration to the apical cell surface during early ciliogenesis. Required for ciliary structure and function, including a role in regulating length and appropriate number through modulating centrosome duplication. Required for cell branching morphology
The "MKS1 Target / Biomarker Review Report" is a customizable review of hundreds up to thousends of related scientific research literature by AI technology, covering specific information about MKS1 comprehensively, including but not limited to:
• general information;
• protein structure and compound binding;
• protein biological mechanisms;
• its importance;
• the target screening and validation;
• expression level;
• disease relevance;
• drug resistance;
• related combination drugs;
• pharmacochemistry experiments;
• related patent analysis;
• advantages and risks of development, etc.
The report is helpful for project application, drug molecule design, research progress updates, publication of research papers, patent applications, etc. If you are interested to get a full version of this report, please feel free to contact us at BD@silexon.ai
More Common Targets
MKX | MLANA | MLC1 | MLEC | MLF1 | MLF1-DT | MLF2 | MLH1 | MLH3 | MLIP | MLIP-AS1 | MLKL | MLLT1 | MLLT10 | MLLT10P1 | MLLT11 | MLLT3 | MLLT6 | MLN | MLNR | MLPH | MLST8 | MLX | MLXIP | MLXIPL | MLYCD | MMAA | MMAB | MMACHC | MMADHC | MMADHC-DT | MMD | MMD2 | MME | MMEL1 | MMGT1 | MMP | MMP1 | MMP10 | MMP11 | MMP12 | MMP13 | MMP14 | MMP15 | MMP16 | MMP17 | MMP19 | MMP2 | MMP2-AS1 | MMP20 | MMP20-AS1 | MMP21 | MMP23A | MMP23B | MMP24 | MMP24-AS1-EDEM2 | MMP24OS | MMP25 | MMP25-AS1 | MMP26 | MMP27 | MMP28 | MMP3 | MMP7 | MMP8 | MMP9 | MMRN1 | MMRN2 | MMS19 | MMS22L | MMS22L-TONSL complex | MMUT | MMXD complex | MN1 | MNAT1 | MND1 | MNDA | MNS1 | MNT | MNX1 | MNX1-AS1 | MOAP1 | MOB1A | MOB1B | MOB2 | MOB3A | MOB3B | MOB3C | MOB4 | MOBP | MOCOS | MOCS1 | MOCS2 | MOCS2-DT | MOCS3 | MOG | MOGAT1 | MOGAT2 | MOGAT3 | MOGS
